Calcium alginate-based Antimicrobial Film Dressings for Potential Healing of Infected Foot Ulcers

Ahmed, Anis; Boateng, Joshua

doi:10.4155/tde-2017-0104

Cited by 44 publications

(19 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Lately, traditional wound dressings (such as bandages of cotton and wool) which passively offer wound safety, have been substituted by innovative dressings that are proficient in providing a favorable environment and distributing active ingredients to the wound to facilitate wound healing. In this respect, a plethora of materials and combinations, both synthetic or natural, have been utilized, with numerous formulations (e.g., sponges [ 10 ], hydrogels [ 62 ], films [ 63 , 64 , 65 ], hydrocolloids [ 66 ], hydrofiber mats [ 67 , 68 ], etc.) and properties that make them appropriate for the management of a specific wound.…”

Section: Ideal Properties Of Wound Dressingsmentioning

confidence: 99%

Treatment Strategies for Infected Wounds

2018

View full text Add to dashboard Cite

The treatment of skin wounds is a key research domain owing to the important functional and aesthetic role of this tissue. When the skin is impaired, bacteria can soon infiltrate into underlying tissues which can lead to life-threatening infections. Consequently, effective treatments are necessary to deal with such pathological conditions. Recently, wound dressings loaded with antimicrobial agents have emerged as viable options to reduce wound bacterial colonization and infection, in order to improve the healing process. In this paper, we present an overview of the most prominent antibiotic-embedded wound dressings, as well as the limitations of their use. A promising, but still an underrated group of potential antibacterial agents that can be integrated into wound dressings are natural products, especially essential oils. Some of the most commonly used essential oils against multidrug-resistant microorganisms, such as tea tree, St. John’s Wort, lavender and oregano, together with their incorporation into wound dressings are presented. In addition, another natural product that exhibits encouraging antibacterial activity is honey. We highlight recent results of several studies carried out by researchers from different regions of the world on wound dressings impregnated with honey, with a special emphasis on Manuka honey. Finally, we highlight recent advances in using nanoparticles as platforms to increase the effect of pharmaceutical formulations aimed at wound healing. Silver, gold, and zinc nanoparticles alone or functionalized with diverse antimicrobial compounds have been integrated into wound dressings and demonstrated therapeutic effects on wounds.

show abstract

Section: Ideal Properties Of Wound Dressingsmentioning

confidence: 99%

Treatment Strategies for Infected Wounds

2018

View full text Add to dashboard Cite

show abstract

“…Diabetics are usually polymedicated, so that CFEAS would be a good alternative with which to minimize drug interactions. In addition, CFEAS treatments would be compatible with dressings and wound drainage which have a proven bactericidal effect [16]. Other dressings or therapeutic approaches that can provide these benefits of CFEAS are less cost-effective and more complex methodologically [13].…”

Section: Resultsmentioning

confidence: 99%

The bacteriostatic effect of controlled-flux electrolyzed acidic solution on healthy hallucal skin

Tejedor

Sánchez-Rodríguez

Mayordomo

et al. 2020

Journal of Tissue Viability

View full text Add to dashboard Cite

Background: There are various treatment protocols to manage the increased bacterial load in plantar ulcers. Recently, Controlled-Flux Electrolyzed Acidic Solution (CFEAS), with a pH less than 3, has appeared to be an effective option since its antimicrobial effect could help in the healing of those ulcers. In order to evaluate its potential in this sense, the aim of the present study was to compare bacterial growth on healthy hallucal skin using two types of bandaging (control and Controlled-Flux Electrolysed Acidic Solution). Material and methods: In a sample of 19 healthy subjects, two experiments were performed. In the first, for each subject, two identical hallux bandages were applied in the early morning. At random between left and right foot, either physiological saline (wetting every 2 h) was applied or nothing (control). In the second, two days later, new bandages were applied as before, but now either wetting with Controlled-Flux Electrolysed Acidic Solution (experimental, again wetting every 2 h) or nothing (control). In each experiment, the bacterial load in the nail fold was assessed at the first moment and after 10 h from standard counts of bacterial colony forming units (CFU). Results: In the first experiment, the CFU counts had increased significantly (p < 0.05) in both toes after the 10-h period. In the second experiment, while the bacterial load increased significantly (p = 0.001) from 0.68 ± 0.8 × 10 4 CFU/cm 2 (the "pre" sample) to 1.3 ± 0.9 × 10 4 CFU/cm 2 (the "post" sample) in the control toe, in the experimental CFEAS toe, the pre sample bacterial load was 0.61 ± 0.6 × 10 4 CFU/cm 2 , and the post sample 0.9 ± 0.8 × 10 4 CFU/cm 2 , with no significant difference between them (p = 0.221). Negative cultures were obtained in 3 cases (15.78%) of the experimental toe post sample, and equal post and pre counts in 2 cases (10.5%). Conclusion: Controlled-Flux Electrolyzed Acidic Solution has an effect on healthy hallucal skin that is bacteriostatic, and in some cases bactericidal. This effect could be very helpful in treating plantar ulcers when there is a greatly increased bacterial load in the wound, thus potentially favoring the normal formation of granulation tissue in the skin and normal healing and closure of the ulcer.

show abstract

“…The film formulation, however, demonstrated slow hydration and swelling, leading to slow NIC release with lower concentration diffusion gradient thereby resulting in lower numbers of non-viable cells in EpiOral TM buccal tissue. However, in general, the results of cell viability (MTT) assay for both the wafers and films demonstrated that the formulations can be considered safe to use, since the percentage of viable cells was more than 70% after exposure, which is the acceptable international standard [55,56].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Clay-Functionalized Wafers and Films for Nicotine Replacement Therapy via Buccal Mucosa

Boateng

Okeke

2019

Pharmaceutics

Self Cite

View full text Add to dashboard Cite

The functional physicochemical properties of nicotine (NIC)-loaded composite freeze-dried wafers and solvent-evaporated films comprising hydroxypropylmethylcellulose (HPMC) and sodium alginate (SA), stabilized with magnesium aluminium silicate (MAS), have been reported. The formulations were characterized for swelling capacity, mucoadhesion, in vitro drug dissolution properties in simulated saliva (SS) and PBS at pH 6.8, and ex vivo and in vitro permeation using pig buccal mucosa membrane and EpiOralTM buccal tissue culture, respectively; finally, the cell viability of the EpiOralTM tissues after contact with the NIC-loaded formulations was investigated using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay and the functional characteristics compared with those of commercially available NIC strips. Swelling and NIC release from the HPMC–SA wafers were more prolonged (30 min) compared to the commercially available NIC strips which disintegrated rapidly and released the drug within 5 min. Generally, swelling, mucoadhesion, and drug release was faster in PBS than in SS, and the presence of MAS was essential for maintaining a high dose recovery compared to non-MAS formulations and commercial NIC strips, which showed lower percentage of NIC content, possibly due to evaporation during analysis. Permeation studies showed that the NIC released was able to cross both porcine buccal membrane and the EpiOralTM buccal tissue, with the latter showing higher permeation flux for all the formulations tested. All the NIC-loaded, MAS-stabilized formulations showed high tissue viability, with values above 80%, showing their great potential for use as buccal delivery platforms for NIC replacement therapy to aid smoking cessation.

show abstract

Calcium alginate-based Antimicrobial Film Dressings for Potential Healing of Infected Foot Ulcers

Abstract: The results confirmed successful design of biocompatible dressings effective against Gram-positive and Gram-negative bacteria. [Formula: see text].

Cited by 44 publications

References 43 publications

Treatment Strategies for Infected Wounds

Treatment Strategies for Infected Wounds

The bacteriostatic effect of controlled-flux electrolyzed acidic solution on healthy hallucal skin

Evaluation of Clay-Functionalized Wafers and Films for Nicotine Replacement Therapy via Buccal Mucosa

Contact Info

Product

Resources

About