Calcium-activated chloride channel regulator 1 (CLCA1): More than a regulator of chloride transport and mucus production

Liu, Cong Lin; Shi, Guo Ping

doi:10.1016/j.waojou.2019.100077

Cited by 37 publications

(35 citation statements)

References 92 publications

(147 reference statements)

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“… 57 CLCA4 is a class of calcium-activated chloride channel regulator. 58 Research has shown that CLCA1 is connected with the development of colorectal cancer. 59 However, the function and mechanism of ADAMDEC1 and CLCA1 in BC are not fully understood.…”

Section: Discussionmentioning

confidence: 99%

Integrated analyses of long noncoding RNAs and mRNAs in the progression of breast cancer

et al. 2021

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Objective The objective was to explore the expression and potential functions of long noncoding RNA (lncRNA) and mRNAs in human breast cancer (BC). Methods Differentially expressed lncRNAs and mRNAs were identified and annotated in BC tissues by using the Agilent human lncRNA assay (Agilent Technologies, Santa Clara, CA, USA) and RNA sequencing. After identification of lncRNAs and mRNAs through quantitative reverse transcription polymerase chain reaction, we conducted a series of functional experiments to confirm the effects of knockdown of one lncRNA, TCONS_00029809, on the progression of BC. Results We discovered 238 lncRNAs and 200 mRNAs that were differentially expressed in BC tissues and para-carcinoma tissue. We showed that differentially expressed mRNAs were related to biological adhesion and biological regulation and mainly enriched in cytokine-cytokine receptor interaction, metabolic pathways, and PI3K-Akt signaling pathway. We created a protein–protein interaction network to analyze the proteins enriched in these pathways. We demonstrated that silencing of TCONS_00029809 remarkably inhibited proliferation, invasion, and migration of BC cells, and accelerated their apoptosis. Conclusions We identified a large number of differentially expressed lncRNAs and mRNAs, which provide data useful in understanding BC carcinogenesis. The lncRNA TCONS_00029809 may be involved in the development of BC.

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Section: Discussionmentioning

confidence: 99%

Integrated analyses of long noncoding RNAs and mRNAs in the progression of breast cancer

et al. 2021

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“…CLCA1 therefore takes part in mucus processing and in the structural arrangement of the mucus (26). In addition, CLCA1 participates in innate immune responses by altering cytokine and chemokine production (25).…”

Section: Discussionmentioning

confidence: 99%

Human intestinal bitter taste receptors regulate innate immune responses and metabolic regulators in obesity

Liszt¹,

Wang²,

Farhadipour³

et al. 2022

Journal of Clinical Investigation

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Bitter taste receptors (taste 2 receptors, TAS2Rs) serve as warning sensors in the lingual system against the ingestion of potentially poisonous food. Here, we investigated the functional role of TAS2Rs in the human gut and focused on their potential to trigger an additional host defense pathway in the intestine. Human jejunal crypts, especially those from individuals with obesity, responded to bitter agonists by inducing the release of antimicrobial peptides (α-defensin 5 and regenerating islet–derived protein 3 α [REG3A]) but also regulated the expression of other innate immune factors (mucins, chemokines) that affected E . coli growth. We found that the effect of aloin on E . coli growth and on the release of the mucus glycoprotein CLCA1, identified via proteomics, was affected by TAS2R43 deletion polymorphisms and thus confirmed a role for TAS2R43. RNA-Seq revealed that denatonium benzoate induced an NRF2-mediated nutrient stress response and an unfolded protein response that increased the expression of the mitokine GDF15 but also ADM2 and LDLR , genes that are involved in anorectic signaling and lipid homeostasis. In conclusion, TAS2Rs in the intestine constitute a promising target for treating diseases that involve disturbances in the innate immune system and body weight control. TAS2R polymorphisms may be valuable genetic markers to predict therapeutic responses.

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“…The von Willebrand factor is a large multimeric glycoprotein found in blood plasma, and mutation of VWA causes bleeding disorders ( Ruggeri and Ware, 1993 ). CLCA family members have been reported in different species, including human (four genes from hCLCA1 to hCLCA4 ), mouse and rat (eight homologs from mCLCA1 to mCLCA8 ), and cow [ bCLCA1 , bCLCA2 (Lu-ECAM-1), bCLCA3 , and bCLCA4 ] ( Liu and Shi, 2019 ). There are six ortholog genes documented in zebrafish: CLCA1 , CLCA5.1 , CLCA5.2 , CLCA1-201 , CLCA1-203 , and CLCA5.1-201 ( Howe et al, 2012 ).…”

Section: Discussionmentioning

confidence: 99%

Comparative Transcriptome Analysis During the Seven Developmental Stages of Channel Catfish (Ictalurus punctatus) and Tra Catfish (Pangasianodon hypophthalmus) Provides Novel Insights for Terrestrial Adaptation

Shang

et al. 2021

Front. Genet.

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Tra catfish (Pangasianodon hypophthalmus), also known as striped catfish, is a facultative air-breather that uses its swim bladder as an air-breathing organ (ABO). A related species in the same order (Siluriformes), channel catfish (Ictalurus punctatus), does not possess an ABO and thus cannot breathe in the air. Tra and channel catfish serve as great comparative models for investigating possible genetic underpinnings of aquatic to land transitions, as well as for understanding genes that are crucial for the development of the swim bladder and the function of air-breathing in tra catfish. In this study, hypoxia challenge and microtomy experiments collectively revealed critical time points for the development of the air-breathing function and swim bladder in tra catfish. Seven developmental stages in tra catfish were selected for RNA-seq analysis based on their transition to a stage that could live at 0 ppm oxygen. More than 587 million sequencing clean reads were generated, and a total of 21,448 unique genes were detected. A comparative genomic analysis between channel catfish and tra catfish revealed 76 genes that were present in tra catfish, but absent from channel catfish. In order to further narrow down the list of these candidate genes, gene expression analysis was performed for these tra catfish-specific genes. Fourteen genes were inferred to be important for air-breathing. Of these, HRG, GRP, and CX3CL1 were identified to be the most likely genes related to air-breathing ability in tra catfish. This study provides a foundational data resource for functional genomic studies in air-breathing function in tra catfish and sheds light on the adaptation of aquatic organisms to the terrestrial environment.

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Calcium-activated chloride channel regulator 1 (CLCA1): More than a regulator of chloride transport and mucus production

Cited by 37 publications

References 92 publications

Integrated analyses of long noncoding RNAs and mRNAs in the progression of breast cancer

Integrated analyses of long noncoding RNAs and mRNAs in the progression of breast cancer

Human intestinal bitter taste receptors regulate innate immune responses and metabolic regulators in obesity

Comparative Transcriptome Analysis During the Seven Developmental Stages of Channel Catfish (Ictalurus punctatus) and Tra Catfish (Pangasianodon hypophthalmus) Provides Novel Insights for Terrestrial Adaptation

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