Calcitriol modulate post-ischemic TLR signaling pathway in ischemic stroke patients

Tajalli-Nezhad, Saeedeh; Mohammadi, Salimeh; Atlasi, Mohammad Ali; Kheiran, Mahdi; Moghadam, Sepideh Etehadi; Naderian, Homayoun; Tameh, Abolfazl Azami

doi:10.1016/j.jneuroim.2022.578013

Cited by 7 publications

(5 citation statements)

References 41 publications

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“…Previous studies have also demonstrated the association between these genes and cerebral stroke. For example, MMP9, TLR2, and TIMP1 are related to proinflammatory pathways following stroke [35][36][37] and inducing PTEN degradation can attenuate cerebral stroke [38]. Our data also revealed that age and sex can affect the diagnosis of stroke.…”

Section: Discussionmentioning

confidence: 54%

The Diagnostic Model of Ligusticum Chuanxiong Hort. Against Cerebral Stroke Using Network Pharmacology and Transcriptomics Analyses

Zhang,

Cai,

Luo

et al. 2023

J. Integr. Neurosci.

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Background: Cerebral stroke is a leading cause of death and disability worldwide. Ligusticum Chuanxiong Hort. (LCH), a well-known Chinese herb, is widely used for the treatment of cerebral stroke. This study aimed to investigate the underlying mechanisms of LCH in cerebral stroke and develop a diagnostic model. Methods: We employed network pharmacology analyses to identify the active compounds, targets, and underlying mechanisms of LCH for treating cerebral stroke. Molecular docking was performed to visualize the binding site between the core active compounds and hub targets. Furthermore, a diagnostic model for cerebral stroke was constructed based on transcriptomic analysis. Results: Our findings revealed that LCH contains multiple active ingredients, including oleic acid and caffeic acid. Protein-protein interaction network analysis identified IL1B,

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Section: Discussionmentioning

confidence: 54%

The Diagnostic Model of Ligusticum Chuanxiong Hort. Against Cerebral Stroke Using Network Pharmacology and Transcriptomics Analyses

Zhang,

Cai,

Luo

et al. 2023

J. Integr. Neurosci.

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“…For example, it downregulates the production of proinflammatory cytokines, including tumor necrosis factor-α and IL-6 (47). A clinical trial conducted on ischemic stroke patients has indicated that 25(OH)D could ameliorate TLR4/NF-kβ signaling pathway after ischemia, as this pathway and its downstream proinflammatory cytokines IL-1β and IL-6 expression were found elevated in ischemic stroke patients (48). Moreover, 25(OH)D may contribute in moderating thrombogenesis and atherosclerotic processes, mainly through modulating free radical formation and atherosclerotic inflammatory cytokines release (49).…”

Section: Discussionmentioning

confidence: 99%

Causal effect of serum 25 hydroxyvitamin D concentration on cardioembolic stroke: Evidence from two-sample Mendelian randomization

Habibi,

Teymoori,

Ebrahimi

et al. 2024

Nutrition, Metabolism and Cardiovascular Diseases

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“…TLRs activate NF-κB signaling by recognizing specific PAMPs or other cytokines, enhancing the expression of genes associated with inflammation as a result, starting the inflammatory response. 33 The signaling pathway of Toll-like receptors (TLRs) and NF-κB is implicated in regulating macrophage polarization, TLR4/NF-κB pathway is one of the earliest and most well-established pathways identified as promoting M1 macrophage polarization. High expression levels of TLR4 have been shown to induce increased M1 and decreased M2 both in vitro and in vivo.…”

Section: Signaling Pathways and Factors Related To Macrophage Polariz...mentioning

confidence: 99%

Macrophage Polarization and the Regulation of Bone Immunity in Bone Homeostasis

Hu,

Shang,

Yang

et al. 2023

JIR

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Bone homeostasis is a dynamic equilibrium state of bone formation and absorption, ensuring skeletal development and repair. Bone immunity encompasses all aspects of the intersection between the skeletal and immune systems, including various signaling pathways, cytokines, and the crosstalk between immune cells and bone cells under both homeostatic and pathological conditions. Therefore, as key cell types in bone immunity, macrophages can polarize into classical pro-inflammatory M1 macrophages and alternative anti-inflammatory M2 macrophages under the influence of the body environment, participating in the regulation of bone metabolism and playing various roles in bone homeostasis. M1 macrophages can not only act as precursors of osteoclasts (OCs), differentiate into mature OCs, but also secrete pro-inflammatory cytokines to promote bone resorption; while M2 macrophages secrete osteogenic factors, stimulating the differentiation and mineralization of osteoblast precursors and mesenchymal stem cells (MSCs), and subsequently increase bone formation. Once the polarization of macrophages is imbalanced, the resulting immune dysregulation will cause inflammatory stimulation, and release a large amount of inflammatory factors affecting bone metabolism, leading to pathological conditions such as osteoporosis (OP), rheumatoid arthritis (RA), and steroid-induced femoral head necrosis (SANFH). In this review, we introduce the signaling pathways and related factors of macrophage polarization, as well as their relationships with immune factors, OB, OC, and MSC. We also discuss the roles of macrophage polarization and bone immunity in various diseases of bone homeostasis imbalance, as well as the factors regulating them, which may help to develop new methods for treating bone metabolic disorders.

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Calcitriol modulate post-ischemic TLR signaling pathway in ischemic stroke patients

Cited by 7 publications

References 41 publications

The Diagnostic Model of Ligusticum Chuanxiong Hort. Against Cerebral Stroke Using Network Pharmacology and Transcriptomics Analyses

The Diagnostic Model of Ligusticum Chuanxiong Hort. Against Cerebral Stroke Using Network Pharmacology and Transcriptomics Analyses

Causal effect of serum 25 hydroxyvitamin D concentration on cardioembolic stroke: Evidence from two-sample Mendelian randomization

Macrophage Polarization and the Regulation of Bone Immunity in Bone Homeostasis

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