Calcitonin, zinc, and testicular function

Chausmer, Arthur B.; Chávez, Carlos J; Wain, R. M.; Daaka, Yehia

doi:10.1016/0026-0495(89)90055-3

Cited by 6 publications

(1 citation statement)

References 20 publications

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“…Six subjects, 4 stunted and 2 short, sexually developed subjects "failed to respond." The non-responses might be attributed to zinc deficiency [90]. Plasma leutinizing hormone (LH) concentration in the short, sexually developed subjects (n‫)5ס‬ was >2 times higher than in the stunted subjects (n‫.…”

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confidence: 99%

Importance of the report “Syndrome of iron deficiency anemia, hepatosplenomegaly, hypogonadism, dwarfism and geophagia”

Sandstead

2001

J Trace Elements Exper Med

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This commentary will focus on clinical research for which Prasad et al.[1] is a plausible progenitor. My assessment is personal because I participated in the studies conducted in Egypt that tested Prasad's hypothesis.When Ananda Prasad [1,2] discussed a patient at the medical-grand-rounds of the Saadi Hospital, Shiraz, Iran in 1958, at the invitation of James Halsted, he was presented a 21-year old farmer with weakness, easy fatigability, dyspnea, and palpitation of ten years' duration. For four years he had been unable to work, was pale, and had frequent nocturnal "fever." He had always been small and sexually underdeveloped. Since childhood had practiced geophagia. His diet had consisted mainly of village bread prepared from wheat, milk, and potatoes. He rarely ate meat of any kind, eggs, or vegetables. He had two living brothers and two sisters, who as far as he knew were well. A sister, age 18 years, had died with edema and jaundice. Two sisters died in early childhood. A third brother, aged 22 years, was short, sexually underdeveloped, had malformed extremities, was mentally retarded and practiced geophagia.The patient's vital signs were pulse 100/minute, blood pressure 105/55 mm Hg, temperature 37.4°C, height 135 cm and weight 29.5 kg. Acral, perioral, perineal, or other regional hyperkeratosis, other dermatitis, cheilosis or angular oral fissures were not described. He was pale and had koilonychia. His genitalia were infantile and secondary sexual development was absent. His liver and spleen were palpable 4 cm below the costal margin.In Prasad's experience this patient was unusual. He therefore studied 10 additional patients [1]. His interpretation of the findings was assisted by a review of zinc [3] that cited evidence of the essentiality of zinc in several species including humans. Even though the accepted paradigm held that primary human zinc deficiency was unlikely because of zinc's wide distribution in the environment, Prasad et al. proposed that zinc deficiency was the major cause of the stunting and hypogonadism.One suspects that most zinc cognoscenti were unaware of Prasad's report. The article was in a journal that most faculty members of schools of agriculture probably did not read. Thus the major impact of Prasad et al's report was to inspire the research

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confidence: 99%

Importance of the report “Syndrome of iron deficiency anemia, hepatosplenomegaly, hypogonadism, dwarfism and geophagia”

Sandstead

2001

J Trace Elements Exper Med

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Experiences with Porcine and Salmon Calcitonin in the Treatment of Paget’s Disease

Wallach¹

1991

Paget’s Disease of Bone

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Infusion of zinc inhibits serum calcitonin levels in patients with various zinc status

et al. 1991

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Serum concentrations of ionized calcium, parathyroid hormone, and calcitonin were measured during zinc infusion in patients of short stature (n = 15); those with insulin-dependent diabetes mellitus (n = 13); and age-matched controls (n = 10). The increase in serum zinc concentrations after zinc infusion resulted in a decrease in the serum calcitonin concentrations but not in concentrations of ionized calcium and parathyroid hormone. A significant negative correlation was obtained between body zinc clearances and decreases in serum calcitonin levels at 60 minutes after the infusion of zinc. Thus, we found a relationship between infusion of zinc and the regulation of calcitonin secretion. We propose that an increase in the serum zinc pool plays a definite role in inhibiting calcitonin secretion from thyroid tissue.

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Calcitonin, zinc, and testicular function

Cited by 6 publications

References 20 publications

Importance of the report “Syndrome of iron deficiency anemia, hepatosplenomegaly, hypogonadism, dwarfism and geophagia”

Importance of the report “Syndrome of iron deficiency anemia, hepatosplenomegaly, hypogonadism, dwarfism and geophagia”

Experiences with Porcine and Salmon Calcitonin in the Treatment of Paget’s Disease

Infusion of zinc inhibits serum calcitonin levels in patients with various zinc status

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