Calcitonin receptors are ancient modulators for rhythms of preferential temperature in insects and body temperature in mammals

Goda, Tadahiro; Doi, Masao; Umezaki, Yujiro; Murai, Ichiro; Shimatani, Hiroyuki; Chu, Michelle; Nguyen, Victoria H.; Okamura, Hitoshi; Hamada, Fumika N.

doi:10.1101/gad.307884.117

Cited by 41 publications

(78 citation statements)

References 67 publications

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“…Nonetheless, the organization of the CALCR gene environment in molluscs is more closely related to the vertebrate homologue genome regions than to the insect DH31R loci. In insects DH31R is associated with water balance regulation and Na + transport and not with tissue mineralization 59 , and recently it has also been associated with regulation of insect body thermal rhythms 60 .…”

Section: Discussionmentioning

confidence: 99%

The calcitonin-like system is an ancient regulatory system of biomineralization

Cardoso

Félix

Ferreira

et al. 2020

Sci Rep

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Biomineralization is the process by which living organisms acquired the capacity to accumulate minerals in tissues. Shells are the biomineralized exoskeleton of marine molluscs produced by the mantle but factors that regulate mantle shell building are still enigmatic. this study sought to identify candidate regulatory factors of molluscan shell mineralization and targeted family B G-protein coupled receptors (GpcRs) and ligands that include calcium regulatory factors in vertebrates, such as calcitonin (cALc). in molluscs, cALc receptor (cALcR) number was variable and arose through lineage and speciesspecific duplications. The Mediterranean mussel (Mytilus galloprovincialis) mantle transcriptome expresses six cALcR-like and two cALc-precursors encoding four putative mature peptides. Mussel cALcR-like are activated in vitro by vertebrate cALc but only receptor cALcRiic is activated by the mussel cALciia peptide (ec 50 = 2.6 ×10 −5 M). Ex-vivo incubations of mantle edge tissue and mantle cells with CALCIIa revealed they accumulated significantly more calcium than untreated tissue and cells. Mussel CALCIIa also significantly decreased mantle acid phosphatase activity, which is associated with shell remodelling. our data indicate the cALc-like system as candidate regulatory factors of shell mineralization. The identification of the CALC system from molluscs to vertebrates suggests it is an ancient and conserved calcium regulatory system of mineralization.

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Section: Discussionmentioning

confidence: 99%

The calcitonin-like system is an ancient regulatory system of biomineralization

Cardoso

Félix

Ferreira

et al. 2020

Sci Rep

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“…Recently, Goda et al (2018) showed that the calcitonin receptor in mammals and its Drosophila homolog, DH31-receptor, share a similar function: controlling circadian body temperature rhythms. Thus, neuropeptide ligands responsible for circadian circuits are not conserved but their G-protein coupled receptors are well-conserved across animal clocks.…”

Section: Discussionmentioning

confidence: 99%

The CCHamide1 Neuropeptide Expressed in the Anterior Dorsal Neuron 1 Conveys a Circadian Signal to the Ventral Lateral Neurons in Drosophila melanogaster

et al. 2018

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The fruit fly Drosophila melanogaster possesses approximately 150 brain clock neurons that control circadian behavioral rhythms. Even though individual clock neurons have self-sustaining oscillators, they interact and synchronize with each other through a network. However, little is known regarding the factors responsible for these network interactions. In this study, we investigated the role of CCHamide1 (CCHa1), a neuropeptide expressed in the anterior dorsal neuron 1 (DN1a), in intercellular communication of the clock neurons. We observed that CCHa1 connects the DN1a clock neurons to the ventral lateral clock neurons (LNv) via the CCHa1 receptor, which is a homolog of the gastrin-releasing peptide receptor playing a role in circadian intercellular communications in mammals. CCHa1 knockout or knockdown flies have a generally low activity level with a special reduction of morning activity. In addition, they exhibit advanced morning activity under light-dark cycles and delayed activity under constant dark conditions, which correlates with an advance/delay of PAR domain Protein 1 (PDP1) oscillations in the small-LNv (s-LNv) neurons that control morning activity. The terminals of the s-LNv neurons show rather high levels of Pigment-dispersing factor (PDF) in the evening, when PDF is low in control flies, suggesting that the knockdown of CCHa1 leads to increased PDF release; PDF signals the other clock neurons and evidently increases the amplitude of their PDP1 cycling. A previous study showed that high-amplitude PDP1 cycling increases the siesta of the flies, and indeed, CCHa1 knockout or knockdown flies exhibit a longer siesta than control flies. The DN1a neurons are known to be receptive to PDF signaling from the s-LNv neurons; thus, our results suggest that the DN1a and s-LNv clock neurons are reciprocally coupled via the neuropeptides CCHa1 and PDF, and this interaction fine-tunes the timing of activity and sleep.

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“…Drosophila flies exhibit a daily cycle of temperature preference; during daytime they prefer higher temperatures, while lower temperatures are preferred at night. This temperature preference rhythm is mediated by the neuropeptide diuretic hormone 31 receptor (Dh31-R) in D. melanogaster during its active phase 28 . Unlike what is found in Drosophila, C. hominivorax larvae are at a constant temperature in the wounds of a living host.…”

Section: Relative Expressionmentioning

confidence: 99%

Genomic analyses of a livestock pest, the New World screwworm, find potential targets for genetic control programs

et al. 2020

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The New World Screwworm fly, Cochliomyia hominivorax, is a major pest of livestock in South America and Caribbean. However, few genomic resources have been available for this species. A genome of 534 Mb was assembled from long read PacBio DNA sequencing of DNA from a highly inbred strain. Analysis of molecular evolution identified 40 genes that are likely under positive selection. Developmental RNA-seq analysis identified specific genes associated with each stage. We identify and analyze the expression of genes that are likely important for host-seeking behavior (chemosensory), development of larvae in open wounds in warm-blooded animals (heat shock protein, immune response) and for building transgenic strains for genetic control programs including gene drive (sex determination, germline). This study will underpin future experiments aimed at understanding the parasitic lifestyle of the screwworm fly and greatly facilitate future development of strains for efficient systems for genetic control of screwworm.

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Calcitonin receptors are ancient modulators for rhythms of preferential temperature in insects and body temperature in mammals

Cited by 41 publications

References 67 publications

The calcitonin-like system is an ancient regulatory system of biomineralization

The calcitonin-like system is an ancient regulatory system of biomineralization

The CCHamide1 Neuropeptide Expressed in the Anterior Dorsal Neuron 1 Conveys a Circadian Signal to the Ventral Lateral Neurons in Drosophila melanogaster

Genomic analyses of a livestock pest, the New World screwworm, find potential targets for genetic control programs

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