Calcitonin receptor binding in the hen neurohypophysis before and after oviposition

Nakayama, Hiroyuki; Nakagawa-Mizuyachi, K.; Takahashi, Tetsuya; Kawashima, Mitsuo

doi:10.3382/ps.2009-00407

Cited by 8 publications

(3 citation statements)

References 36 publications

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“…The decrease in the number of peptide hormone receptors might have been caused by internalization when the hormone acted on its receptor (Muller et al, 1985). Such changes in receptor binding have been reported in the luteinizing hormone-releasing hormone-I receptor of the chicken anterior pituitary (Kawashima et al, 1992), and in the calcitonin receptor of the chicken neurohypophysis (Nakayama et al, 2010a) after an injection of each hormone. The results in the present study suggest that the PTHrP may act directly on the anterior pituitary via its receptor binding and stimulate ACTH secretion from this tissue.…”

Section: Discussionmentioning

confidence: 94%

Parathyroid hormone-related peptide directly increases adrenocorticotropic hormone secretion from the anterior pituitary in hens

Nakayama¹,

Takahashi

Oomatsu³

et al. 2011

Poultry Science

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The presence of the receptor for parathyroid hormone-related peptide (PTHrP) and the effect of PTHrP on adrenocorticotropic hormone (ACTH) secretion in the hen anterior pituitary were examined. The plasma membrane fraction of the anterior pituitary was found to contain a specific chicken PTHrP (cPTHrP) binding component. The binding component had properties of a receptor, such as binding specificity to cPTHrP, reversibility, saturable binding, high affinity, and limited capacity; therefore, it was elucidated that the PTHrP receptor exists in the plasma membrane of the hen anterior pituitary. A third ventricular injection of cPTHrP in nonlaying hens caused a decrease in the chicken ACTH level of the anterior pituitary and an increase in the chicken ACTH level of blood plasma, with an increase in the binding affinity and a decrease in the binding capacity of PTHrP receptor in the anterior pituitary. The present study suggests that PTHrP may act directly on the anterior pituitary via its receptor binding and may enhance ACTH secretion from this tissue in hens.

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Section: Discussionmentioning

confidence: 94%

Parathyroid hormone-related peptide directly increases adrenocorticotropic hormone secretion from the anterior pituitary in hens

Nakayama¹,

Takahashi

Oomatsu³

et al. 2011

Poultry Science

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“…1992; Takahashi et al . 1994b; Nakayama et al . 2010b), the binding capacity of the CT receptor in the present study might decrease as a result of an increase in the CT action by an increase in the receptor binding affinity at 3 h before oviposition.…”

Section: Discussionmentioning

confidence: 99%

Calcitonin receptor binding in the hen anterior pituitary during an oviposition cycle

Nakayama

Takahashi

Nakagawa-Mizuyachi

et al. 2011

Animal Science Journal

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The equilibrium dissociation constant (K(d) ) and the maximum binding capacity (B(max) ) of calcitonin (CT) receptor in the plasma membrane of the anterior pituitary in hens were examined by Scatchard analysis of specific binding of (125) I-labeled chicken CT. Values of K(d) and B(max) of CT receptor were smaller in laying hens than in non-laying hens. A decrease in the K(d) and B(max) value of CT receptor was observed in the anterior pituitary after the injection of estradiol-17β and progesterone into nonlaying hens, but not changed after the injection of 5α-dihydrotestosterone. During an oviposition cycle, the K(d) and the B(max) value decreased 3 h before oviposition. In non-laying hens, neither the K(d) nor the B(max) value changed during a full day period. The present study suggests that the CT action on the anterior pituitary may increase 3 h before oviposition by the effect of estradiol-17β and progesterone in laying hens.

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“…(Scatchard, 1949) in saturation experiments is often used in investigations of binding affinities and the capacities of hormone receptors (Takahashi and Kawashima, 2009ab;Nakagawa-Mizuyachi et al, 2010). The kinetic dissociation constant, which is calculated from the ratio of the dissociation rate constant (K −1 ) to the association rate constant (K +1 ), is also used in investigations of binding affinities of hormones and their receptors (Takahashi et al, 1997;Nakagawa-Mizuyachi et al, 2009;Takahashi and Kawashima, 2009b;Nakayama et al, 2010). Therefore, these methods were used to estimate binding affinity and Scatchard analysis was used to estimate binding capacity in the present study.…”

Section: Introductionmentioning

confidence: 99%

Changes in angiotensin II receptor bindings in the hen neurohypophysis before and after oviposition

et al. 2011

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The present study was performed to elucidate whether the angiotensin II (ANG II) receptor exists in the plasma membrane fraction of the neurohypophysis in hens, to estimate the time of action of ANG II on the neurohypophysis before and after oviposition, and to examine relationships between the action of ANG II on the neurohypophysis and those of estrogen and prostaglandin F(2α) (PGF(2α)) in relation to arginine vasotocin (AVT) release. The specific binding had a binding specificity to chicken ANG II (cANG II), reversibility, and saturation in the [(125)I]cANG II binding assay. Scatchard analysis revealed that the binding sites are of a single class. The equilibrium dissociation constant (K(d)) obtained by kinetic analysis and Scatchard analysis suggested a high affinity, and the maximum binding capacity (B(max)) obtained by Scatchard analysis suggested a limited capacity. These results suggest that an ANG II receptor exists in the neurohypophysis of hens. The K(d) and the B(max) value was significantly smaller in laying hens than in nonlaying hens, which suggests that bindings of the cANG II receptor change, depending on the difference in laying condition. Values of the K(d) and the B(max) decreased approximately 15 min before oviposition in laying hens, and decreased 1 h after an intramuscular injection of estradiol-17β and 5 min after an intravenous injection of cANG II in nonlaying hens. The amount of specific binding of PGF(2α) receptor in the neurohypophysis also decreased and AVT concentration in blood increased after the cANG II injection. It seems likely that the action of cANG II in the neurohypophysis increases due to the effect of estrogen approximately 15 min before oviposition, and the cANG II action stimulates AVT release through the increase in the PGF(2α) action in this tissue.

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Calcitonin receptor binding in the hen neurohypophysis before and after oviposition

Cited by 8 publications

References 36 publications

Parathyroid hormone-related peptide directly increases adrenocorticotropic hormone secretion from the anterior pituitary in hens

Parathyroid hormone-related peptide directly increases adrenocorticotropic hormone secretion from the anterior pituitary in hens

Calcitonin receptor binding in the hen anterior pituitary during an oviposition cycle

Changes in angiotensin II receptor bindings in the hen neurohypophysis before and after oviposition

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