Calcitonin‐producing insulinoma: clinical, immunocytochemical and cytogenetical study

Bugalho, Maria João; Roque, Lúcia; Sobrinho, L. G.; Höög, Anders; Nunes, J. F.; Aimeida, José M. Mendes; Leltão, C. Nobre; Santos, Jorge Rosa; Pereira, Maria Conceição; Santos, Maria do Carmo; Soares, Jorge

doi:10.1111/j.1365-2265.1994.tb02539.x

Cited by 18 publications

(19 citation statements)

References 10 publications

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“…There are a few conditions other than MTC that can be associated with detectable levels of CT. Among these are different neuroendocrine tumors [25,26] and, clinically more relevant, non-neoplastic thyroid diseases namely Hashimoto thyroiditis [27][28][29]. Introduction of assays specific for the mature and bioactive form of CT [24] virtually abolished the false positives secondary to the presence of different forms of CT in circulation [23,30,31].…”

Section: Discussionmentioning

confidence: 99%

Preoperative diagnosis of medullary thyroid carcinoma: Fine needle aspiration cytology as compared with serum calcitonin measurement

Bugalho

Santos

Sobrinho

2005

Journal of Surgical Oncology

122

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Section: Discussionmentioning

confidence: 99%

Preoperative diagnosis of medullary thyroid carcinoma: Fine needle aspiration cytology as compared with serum calcitonin measurement

Bugalho

Santos

Sobrinho

2005

Journal of Surgical Oncology

122

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“…However, pentagastrin is not always available despite being the most used secretagogue. In patients with neuroendocrine tumors other than MTC, serum Ctn levels do not increase in response to pentagastrin or calcium stimulation, contributing for the differential diagnosis [18, 19, 22]. …”

Section: Discussionmentioning

confidence: 99%

Calcitonin Screening in Nodular Thyroid Disease: Is There a Definitive Answer?

Silvestre¹,

Matias²,

Proença³

et al. 2018

Eur Thyroid J

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Introduction: Calcitonin (Ctn) is a hormone secreted by thyroid “C” cells and is considered an excellent marker for medullary thyroid carcinoma (MTC). However, the use of Ctn to screen patients with nodular thyroid disease (NTD) remains controversial. Objective: The aim of this work was to define the frequency of hypercalcitoninemia among NTD patients followed at a tertiary referral hospital. Methods: A retrospective analysis was made of basal Ctn measurements and corresponding patients’ records between January 2011 and December 2015. Hypercalcitoninemia was defined as > 10 pg/mL. Depending on the Ctn value, three groups were considered: G1, ≤10 pg/mL; G2, 10–100 pg/mL; G3, ≥100 pg/mL. Results: Ctn was requested in an NTD context for 1,504 patients, 69 of whom had hypercalcitoninemia. Of these, 20 underwent surgery (G2, 11; G3, 9), and a histological diagnosis of MTC was established in 12 (G2, 3/27%; G3, 9/100%). Surgery was chosen based solely on Ctn levels in 7 cases, since only 5 had a positive cytology. Conclusions: Hypercalcitoninemia was found in 4.6% of NTD patients. Ctn levels ≥100 pg/mL were associated with a greater CMT risk than values between 10 and 100 pg/mL, reinforcing results from other groups. The need for an adequate interpretation of results as well as an appropriate selection of patients to surgery stresses the importance of endocrinologists requesting and interpreting results.

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“…On the other hand, spuriously elevated serum CT in patients with a thyroid nodule may be secondary to the use of methods unable to distinguish the different molecular weight forms of CT in circulation (23). Furthermore, moderately high levels of serum CT, even in patients with goiter, may have a non-thyroidal origin resulting from a neuroendocrine tumour located elsewhere (24). Detection of circulating thyroid cells in peripheral blood.…”

Section: Discussionmentioning

confidence: 99%

Medullary thyroid carcinoma: an accurate pre-operative diagnosis by reverse transcription-PCR

Bugalho¹,

Mendonça²,

Sobrinho³

2000

European Journal of Endocrinology

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Objective: To study the expression of calcitonin (CT) and thyroglobulin mRNA in samples of leftover cells in needles used for ®ne-needle aspiration biopsy either from thyroid tumours or cervical lymph nodes. Patients and methods: Specimens were analysed using reverse transcription-polymerase chain reaction; 12 samples from 11 patients were included and molecular diagnosis was compared with cytological or histological diagnosis and serum CT measurements. Results: Transcripts of the CT gene were detected in all six patients with medullary thyroid carcinoma (MTC) but in none of the other patients. Conclusions: Present data reinforce this technique as a reliable and alternative tool to establish the preoperative diagnosis of MTC, especially when cytological examination is not conclusive or when cytological information is not in agreement with clinical data. Furthermore, it may be clinically useful to identify those conditions in which increased serum CT in the presence of a thyroid nodule is not due to MTC.

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Calcitonin‐producing insulinoma: clinical, immunocytochemical and cytogenetical study

Cited by 18 publications

References 10 publications

Preoperative diagnosis of medullary thyroid carcinoma: Fine needle aspiration cytology as compared with serum calcitonin measurement

Preoperative diagnosis of medullary thyroid carcinoma: Fine needle aspiration cytology as compared with serum calcitonin measurement

Calcitonin Screening in Nodular Thyroid Disease: Is There a Definitive Answer?

Medullary thyroid carcinoma: an accurate pre-operative diagnosis by reverse transcription-PCR

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