Calcitonin gene‐related peptide released by capsaicin suppresses myoelectrical activity of gastric smooth muscle

Abstract

These results suggest that the suppression of the myoelectrical activity of gastric smooth muscle by capsaicin is attributable to the endogenous CGRP released.

Neuronal system-dependent facilitation of tumor angiogenesis and tumor growth by calcitonin gene-related peptide

“…CGRP is synthesized by sensory C-fibers throughout the respiratory tree and potently constricts airway smooth muscle (11). The tissues contained considerably more CGRP compared with substance P (12,13). We reported that CGRP also exhibited important roles in the gastrointestinal tract (14,15).…”

Roles of prostaglandin E2-EP1 receptor signaling in regulation of gastric motor activity and emptying

“…A fixed intragastric pressure was maintained by closing both catheters for 10 min. Body temperature was maintained at 36.5-37.5°C by means of a heating lamp and a warm plate during the experiments.A bipolar electrode (TF201-076, Unique Medical, Tokyo, Japan), newly made as an improvement on the original bipolar electrode (24,25), was fixed with a cotton thread (no. 80) to the serosal surface of the antrum, 5 mm from the pylorus of the stomach.…”

Protective Effects of Gastric Mucus

“…These neurons not only serve a sensory and afferent role, but also display a local effector function initiated by the release of neuropeptide transmitters, such as calcitonin gene-related peptide (CGRP) and substance P, from their peripheral nerve endings. CGRP is reported to exhibit significant mucosal protective roles in the gastrointestinal tract (Ichikawa et al, 2000c;Mizuguchi et al, 2005;Ohno et al, 2008). The action of CGRP is in part mediated by endogenous NO.…”