Calcitonin Gene-related Peptide Receptor Expression in Alternatively Activated Monocytes/Macrophages During Irreversible Pulpitis

Caviedes-Bucheli, Javier; Moreno, Gloria Cristina; López, María Paula; Bermeo-Noguera, Ana Milena; Pacheco-Rodríguez, Gloriana; Cuéllar, Adriana; Munoz, H. R.

doi:10.1016/j.joen.2008.05.011

Cited by 18 publications

(14 citation statements)

References 34 publications

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“…1,20 Several studies have reported an increased expression of CGRP on teeth with irreversible pulpitis compared with teeth having healthy pulps. 1,3,11,12,21 In this study, we observed higher values of the gene, of the gene of the receptor, and of the expression of CGRP in the irreversible pulpitis group (P = .0001). CGRP interacts with mast cells and induces histamine release, which increases vascular permeability and blood pressure.…”

Section: Expression Of Cgrp In Teeth With Irreversible Pulpssupporting

confidence: 46%

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Expression of calcitonin gene-related peptide and pulp sensitivity tests in irreversible pulpitis

et al. 2019

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The aim of the present study was to identify the relationship between the expression of calcitonin gene-related peptide (CGRP) and the responses of pulp sensitivity tests in healthy pulps and irreversible pulps by performing a cross-sectional study on patients. Two hundred subjects were evaluated. A total of 75 subjects complied with the criteria. The participants were divided into two groups: a) Healthy pulp (subjects [n = 35] having posterior teeth with clinically normal pulp tissue), and b) Irreversible pulpitis (subjects [n = 40] having posterior teeth with irreversible pulpitis). All participants were evaluated using the following variables: a) medical and dental history, b) pulp sensitivity tests, c) expression of CGRP by the enzyme-linked immunosorbent assay (ELISA), and d) expression levels of mRNA CGRP and mRNA CGRP receptor genes. We determined that the responses of the cold test between 4 and ≥12 s presented a higher average of the expression of CGRP in the group having irreversible pulpitis (p = 0.0001). When we compared the groups with the value of the electrical impulse, we found statistically significant differences (p = 0.0001), observing positive responses to the test with electrical impulses of 7 to 10, with an average of 72.15 ng/mL of CGRP in the irreversible pulpitis group. High values of CGRP expression were observed in that group in the responses of pulp sensitivity.

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Section: Expression Of Cgrp In Teeth With Irreversible Pulpssupporting

confidence: 46%

“…thromboxanes. 3 Measures such as medical and dental histories, clinical examinations, specific pulp tests, and radiographic analyses are necessary to diagnose pulpitis. Pulp sensitivity tests are frequently used in clinical practice because of their simplicity and low cost.…”

Section: Introductionmentioning

confidence: 99%

Expression of calcitonin gene-related peptide and pulp sensitivity tests in irreversible pulpitis

et al. 2019

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“…CGRP receptor is also expressed on human monocytes (Caviedes-Bucheli et al, 2008). Under the influence of NGF, CGRP has been shown to regulate the expression of MHCII, CD86 and the production of IL10 in human monocytes in vitro (Bracci-Laudiero et al, 2005).…”

Section: Regulation Of Other Immune Cellsmentioning

confidence: 99%

Calcitonin gene-related peptide is a key neurotransmitter in the neuro-immune axis

2014

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The question of how the neural and immune systems interact in host defense is important, integrating a system that senses the whole body with one that protects. Understanding the mechanisms and routes of control could produce novel and powerful ways of promoting and enhancing normal functions as well as preventing or treating abnormal functions. Fragmentation of biological research into specialities has resulted in some failures in recognizing and understanding interactions across different systems and this is most striking across immunology, hematology, and neuroscience. This reductionist approach does not allow understanding of the in vivo orchestrated response generated through integration of all systems. However, many factors make the understanding of multisystem cross-talk in response to a threat difficult, for instance the nervous and immune systems share communication molecules and receptors for a wide range of physiological signals. But, it is clear that physical, hard-wired connections exist between the two systems, with the key link involving sensory, unmyelinated nerve fibers (c fibers) containing the neuropeptide calcitonin gene-related peptide (CGRP), and modified macrophages, mast cells and other immune and host defense cells in various locations throughout the body. In this review we will therefore focus on the induction of CGRP and its key role in the neuroimmune axis.

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“…CGRP is a 37‐aa peptide belonging to the calcitonin family of peptides. Its biological effects are mediated by a heterodimeric receptor composed of the calcitonin receptor like‐receptor (a G protein‐coupled receptor) and the receptor activity‐modifying protein 1, which is expressed by inflammatory cells (such as monocytes‐macrophages and mast cells), endothelial cells, and epidermal cells (keratinocytes, melanocytes and Langerhans cells) …”

Section: Neuropeptides (Figure )mentioning

confidence: 99%

Role of neuropeptides, neurotrophins, and neurohormones in skin wound healing

Chéret

Lebonvallet

Carré

et al. 2013

Wound Repair Regeneration

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Due to the close interactions between the skin and peripheral nervous system, there is increasing evidence that the cutaneous innervation is an important modulator of the normal wound healing process. The communication between sensory neurons and skin cells involves a variety of molecules (neuropeptides, neurohormones, and neurotrophins) and their specific receptors expressed by both neuronal and nonneuronal skin cells. It is well established that neurotransmitters and nerve growth factors released in skin have immunoregulatory roles and can exert mitogenic actions; they could also influence the functions of the different skin cell types during the wound healing process.

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Calcitonin Gene-related Peptide Receptor Expression in Alternatively Activated Monocytes/Macrophages During Irreversible Pulpitis

Cited by 18 publications

References 34 publications

Expression of calcitonin gene-related peptide and pulp sensitivity tests in irreversible pulpitis

Expression of calcitonin gene-related peptide and pulp sensitivity tests in irreversible pulpitis

Calcitonin gene-related peptide is a key neurotransmitter in the neuro-immune axis

Role of neuropeptides, neurotrophins, and neurohormones in skin wound healing

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