Calcitonin Gene Related Peptide Gene Polymorphism in Migraine Patients

Abstract

Abstract:Objective:Calcitonin gene related peptide (CGRP), which has a vasodilator effect, is held responsible for neurogenic inflammation and vasodilatation of the cranial vessels in migraine pathophysiology. In this study, we investigated the association between alpha CGRP gene polymorphism (CALCA T-692C) and migraine.Material and Methods:One hundred and thirty-four female migraineurs and 96 healthy female cases were enrolled in the study. The patient group was further subdivided into migraine with and without aura groups. The CALCA T-692C gene polymorphism was identified using polymerase chain reaction (PCR) technique and restriction fragment length polymorphism (RFLP).Results:The genotype and allele frequencies of CALCA T-692C gene polymorphism did not differ between the migraine and control groups. Between the migraine with and without aura subgroups, there was no difference. No association was seen between the CALCA T-692C gene polymorphisms and migraine attack severity and frequency.Conclusion:Our study did not show any association between CALCA T-692C gene polymorphism and migraine.

Calcitonin Gene-Related Peptide in Serum After Spontaneous Subarachnoid Hemorrhage

“…Intrinsic production in the trigeminal ganglion of Gasseri, neuronal transport, presynaptic release and consecutive re-uptake have been evaluated in detail and the major role of CGRP in migraine has been repeatedly confirmed (Guldiken et al, 2013). However, consistent data on CGRP in the context of aneurysmal SAH-related vasospasm and subsequent CI are still missing.…”

Association of RAMP1 rs7590387 With the Risk of Migraine Transformation Into Medication Overuse Headache

“…38 Although serotonin has been implicated in the predisposition to substance-related disorders, 39,40 no evidence of correlation has been reported between serotonergic gene variants and MOH risk. [25][26][27]41 Despite lack of association between variants in CALCA and RAMP1 genes and migraine susceptibility, 22,42,43 polymorphisms at these loci could have a role in migraine chronification. This possibility has been raised in a recent study with a three-stage design evaluating 144 SNPs selected from 48 candidate genes.…”

Calcitonin-Related Polypeptide Alpha Gene Polymorphisms and Related Diseases

“…Migraine, a common disease, is characterized by unilateral throbbing headache with autonomic symptoms such as nausea, vomiting, and photophobia. Although the pathogenesis of migraine is still unclear, it is known that genetic and environmental factors play a role in the pathophysiology of this disease [12].…”

“…Pain signals are induced, and they transmitted to the thalamus. These signals are perceived as headache by the cerebral cortex [12].…”

“…When properly administered, CGRP antagonists can prevent migraine attacks. Nitric oxide is another substance that plays an important role in the pathogenesis of migraine, and nitric oxide effect is seen in consequence of CGRP release in the trigeminal nerve terminals [12].…”