Calcitonin gene-related peptide and substance P in afferents to the upper gastrointestinal tract in the rat

Green, T.; Dockray, Graham J.

doi:10.1016/0304-3940(87)90707-5

Cited by 151 publications

(84 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Gastric spinal afferents terminate in laminas I, V-VII, and X of the mid-thoracic to upper lumbar spinal cord (Green and Dockray, 1987). Spinal viscerosensory fibers converge with somatic sensory fibers onto dorsal horn neurons that give rise to the ascending spinothalamic tract.…”

Section: Discussionmentioning

confidence: 99%

Anterograde Transneuronal Viral Tracing of Central Viscerosensory Pathways in Rats

2004

View full text Add to dashboard Cite

Previous studies demonstrated that strain H129 of herpes simplex virus-1 undergoes anterograde transneuronal transport in mice and primates after peripheral or central injection. In this study, H129 was used in rats to identify CNS regions that receive relayed viscerosensory inputs from the stomach wall. We also examined whether transneuronal viral transport in this model is exclusively anterograde. H129 or an established retrograde transneuronal viral tracer, pseudorabies virus (PRV), was injected into the ventral stomach wall in intact rats or in rats with previous subdiaphragmatic vagal sensory deafferentation. Rats were perfused with fixative 3-5 d later, and tissues were processed for immunocytochemical detection of transported virus. In intact rats, H129 was transported transneuronally via vagal and spinal viscerosensory neurons to postsynaptic target cells in the medullary dorsal vagal complex and thoracic dorsal horn, respectively, with subsequent transport to discrete regions of the medullary and pontine reticular formation, cerebellum, parabrachial nucleus, periaqueductal gray, thalamus, hypothalamus, amygdala, bed nucleus of the stria terminalis, and other central sites. Comparison of labeling patterns in intact and vagal deafferented rats indicated that H129 also produced first-order retrograde infection of autonomic neurons that project directly to virus injection sites, similar to PRV. Unlike PRV, however, H129 was not transported transneuronally in the retrograde direction from infected neurons to central sources of presynaptic input. We conclude that transneuronal transport of H129 occurs exclusively in the anterograde direction to reveal CNS regions that receive direct and relayed viscerosensory signals.

show abstract

Section: Discussionmentioning

confidence: 99%

Anterograde Transneuronal Viral Tracing of Central Viscerosensory Pathways in Rats

2004

View full text Add to dashboard Cite

show abstract

“…Immunohistochemical study has shown that capsaicin-sensitive afferent neurons innervat ing the rat stomach contain substance P (20) and calcitonin gene-related peptide (21). Therefore, studying the effect of capsaicin sensitive nerve degeneration on the fundic mucosal level and the antral mucosal level of substance P or calcitonin gene-related peptide may provide a means for clarifying the differ ent susceptibility to capsaicin-sensitive nerve degeneration in the fundic mucosa and the antral mucosa.…”

Section: Discussionmentioning

confidence: 99%

Aggravation by the Capsaicin-Treatment of Gastric Antral Ulcer Induced by the Combination of 2-Deoxy-D-Glucose, Aspirin and Ammonia in Rats.

1991

View full text Add to dashboard Cite

ABSTRACT-The effect of capsaicin-sensitive nerve degeneration (capsaicin-treat ment) was investigated on the antral ulcer induction by the combined administration of 2-deoxy-D-glucose (2-DG; 200 mg/kg, i.v.), aspirin (200 mg/kg, p.o.) and 1% ammonia solution (10 ml/kg, p.o.) in male Sprague-Dawley rats. On the 2nd day after ulcer induction, erosive lesions were seen in the corpus, and ulcers penetrating into the muscularis mucosae were also seen in the antrum. In the capsaicin-treated rats, the antral ulcer was significantly aggravated as compared with that in capsaicin non treated rats, although no difference was noted in the formation of corpus lesions be tween capsaicin-treated rats and non-treated rats. Acid output was investigated in pylorus ligated rats. 2-DG significantly increased the acid output. A significant in crease in acid output was also observed in capsaicin-treated rats, and this increase tended to be augmented by the additional treatment with 2-DG. Atropine sulfate inhib ited the significant increase in acid output of the capsaicin-treated rats. In all rats, both capsaicin-treated and pylorus-ligated, 2-DG induced antral ulcers that penetrated into the muscularis mucosae. From the above results, it was suggested that capsaicin sensitive nerve degeneration modifies the gastroprotective ability in the antral mucosa to a greater extent than in the fundic mucosa, and this aggravation may be caused by activation of the vagus nerve, although the role of acid is not completely excluded.

show abstract

“…In rats, spinal viscerosensory afferents terminate in laminae I-VII of the dorsal horn and intermediate zone, and in lamina X around the central canal [1]. Inputs from visceral and somatic sensory afferents converge onto common second order neurons within the spinal dorsal horn.…”

Section: Visceral Sensory Inputs To Spinal Cord and Caudal Brainstemmentioning

confidence: 99%

Visceral sensory inputs to the endocrine hypothalamus

Rinaman

2007

Frontiers in Neuroendocrinology

View full text Add to dashboard Cite

Interoceptive feedback signals from the body are transmitted to hypothalamic neurons that control pituitary hormone release. This review article describes the organization of central neural pathways that convey ascending visceral sensory signals to endocrine neurons in the paraventricular (PVN) and supraoptic nuclei (SON) of the hypothalamus in rats. A special emphasis is placed on viscerosensory inputs to corticotropin releasing factor (CRF)-containing PVN neurons that drive the hypothalamic-pituitary-adrenal axis, and on inputs to magnocellular PVN and SON neurons that release vasopressin (AVP) or oxytocin (OT) from the posterior pituitary. The postnatal development of these ascending pathways also is considered.

show abstract

Calcitonin gene-related peptide and substance P in afferents to the upper gastrointestinal tract in the rat

Cited by 151 publications

References 20 publications

Anterograde Transneuronal Viral Tracing of Central Viscerosensory Pathways in Rats

Anterograde Transneuronal Viral Tracing of Central Viscerosensory Pathways in Rats

Aggravation by the Capsaicin-Treatment of Gastric Antral Ulcer Induced by the Combination of 2-Deoxy-D-Glucose, Aspirin and Ammonia in Rats.

Visceral sensory inputs to the endocrine hypothalamus

Contact Info

Product

Resources

About