Calcitonin gene-related peptide and neurologic injury: An emerging target for headache management

Mehkri, Yusuf; Hanna, Chadwin; Sriram, Sriniwas; Lucke‐Wold, Brandon; Johnson, Richard D.; Busl, Katharina M.

doi:10.1016/j.clineuro.2022.107355

Cited by 10 publications

(2 citation statements)

References 62 publications

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“…Triptans, serotonin 1B/1D receptor agonists and CGRP antagonists may be poor choices as they vasoconstrict cerebral vasculature ( 6 ), have case reports of association with reversible cerebral vasoconstriction syndrome and can theoretically worsen DCI in aSAH patients ( 28 ). The use of CGRP-modulating therapies in acute conditions such as traumatic brain injury and SAH continues to be explored ( 29 , 30 ). Data on the effectiveness and safety of NSAIDs are limited in HASH, with over 50% of providers stating they rarely or never used NSAIDS in this setting ( 9 ), likely due to perceived risk of worsening bleeding.…”

Section: Discussionmentioning

confidence: 99%

Safety and efficacy of peripheral nerve blocks to treat refractory headaches after aneurysmal subarachnoid hemorrhage – A pilot observational study

et al. 2023

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ObjectivesHeadache after aneurysmal subarachnoid hemorrhage (HASH) is common, severe, and often refractory to conventional treatments. Current treatment standards include medications including opioids, until the pain is mitigated. Peripheral nerve blocks (PNBs) may be an effective therapeutic option for HASH. We conducted a small before-and-after study of PNBs to determine safety, feasibility, and efficacy in treatment of HASH.MethodsWe conducted a pilot before-and-after observational study and collected data for 5 patients in a retrospective control group and 5 patients in a prospective intervention PNB group over a 12-month period. All patients received a standard treatment of medications including acetaminophen, magnesium, gabapentin, dexamethasone and anti-spasmodics or anti-emetics as needed. Patients in the intervention group received bilateral greater occipital, lesser occipital, and supraorbital PNBs in addition to medications. The primary outcome was pain severity, measured by Numeric pain rating scale (NPRS). All patients were followed for 1 week following enrollment.ResultsThe mean ages in the PNB group and control group were 58.6 and 57.4, respectively. One patient in the control group developed radiographic vasospasm. Three patients in both groups had radiographic hydrocephalus and IVH, requiring external ventricular drain (EVD) placement. The PNB group had an average reduction in mean raw pain score of 2.76 (4.68, 1.92 p = 0.024), and relative pain score by 0.26 (0.48, 0.22 p = 0.026), compared to the control group. The reduction occurred immediately after PNB administration.ConclusionPNB can be a safe, feasible and effective treatment modality for HASH. Further investigations with a larger sample size are warranted.

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Section: Discussionmentioning

confidence: 99%

Safety and efficacy of peripheral nerve blocks to treat refractory headaches after aneurysmal subarachnoid hemorrhage – A pilot observational study

et al. 2023

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“…As an important sensory neuropeptide, CGRP is widely expressed in the nervous system and exists in two forms, i.e., α-CGRP and β-CGRP ( Lv et al, 2022 ). CGRP plays important roles in migraine pathophysiology, inflammatory response, and blood pressure ( Mehkri et al, 2022 ). At present, good progress has been made in the drug research of GCRP and CGRPR, and four related monoclonal antibodies have been developed ( Deganutti et al, 2021 ).…”

Section: Roles Of Class B1 G Protein-coupled Receptors In Cochleamentioning

confidence: 99%

G protein-coupled receptors in cochlea: Potential therapeutic targets for hearing loss

Guo²,

Fu³

et al. 2022

Front. Mol. Neurosci.

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The prevalence of hearing loss-related diseases caused by different factors is increasing worldwide year by year. Currently, however, the patient’s hearing loss has not been effectively improved. Therefore, there is an urgent need to adopt new treatment measures and treatment techniques to help improve the therapeutic effect of hearing loss. G protein-coupled receptors (GPCRs), as crucial cell surface receptors, can widely participate in different physiological and pathological processes, particularly play an essential role in many disease occurrences and be served as promising therapeutic targets. However, no specific drugs on the market have been found to target the GPCRs of the cochlea. Interestingly, many recent studies have demonstrated that GPCRs can participate in various pathogenic process related to hearing loss in the cochlea including heredity, noise, ototoxic drugs, cochlear structure, and so on. In this review, we comprehensively summarize the functions of 53 GPCRs known in the cochlea and their relationships with hearing loss, and highlight the recent advances of new techniques used in cochlear study including cryo-EM, AI, GPCR drug screening, gene therapy vectors, and CRISPR editing technology, as well as discuss in depth the future direction of novel GPCR-based drug development and gene therapy for cochlear hearing loss. Collectively, this review is to facilitate basic and (pre-) clinical research in this area, and provide beneficial help for emerging GPCR-based cochlear therapies.

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Can Long-Term Outcomes of Posttraumatic Headache be Predicted?

Kingsford,

Yehya,

Zieman

et al. 2024

Curr Pain Headache Rep

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Calcitonin gene-related peptide and neurologic injury: An emerging target for headache management

Cited by 10 publications

References 62 publications

Safety and efficacy of peripheral nerve blocks to treat refractory headaches after aneurysmal subarachnoid hemorrhage – A pilot observational study

Safety and efficacy of peripheral nerve blocks to treat refractory headaches after aneurysmal subarachnoid hemorrhage – A pilot observational study

G protein-coupled receptors in cochlea: Potential therapeutic targets for hearing loss

Can Long-Term Outcomes of Posttraumatic Headache be Predicted?

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