Calcitonin gene-related peptide and its receptor components in the human sphenopalatine ganglion — Interaction with the sensory system

Migraine and neuropeptides

“…This statement is supported clinically by the finding that roughly 30% of migraine patients develop cranial autonomic parasympathetic symptoms such as lacrimation, rhinorrhoea and eyelid oedema (Avnon et al, 2003(Avnon et al, , 2004Barbanti et al, 2002;Gupta and Bhatia, 2007;Obermann et al, 2007). Immunohistological findings have revealed CGRP-ir nerve fibres in the SPG, CLR immunoreactivity in the SGCs and RAMP-1 immunoreactivity in the neurons and SGCs in the SPG (Csati et al, 2012b). These data suggest an interaction between the sensory and parasympathetic systems in the cranial ganglia (Csati et al, 2012b).…”

“…An immunohistochemical study revealed CGRP-ir fibres in the vicinity of the neurons of the sphenopalatine ganglia (SPG), and CLR and RAMP-1 immunoreactivity in the SGCs (Csati et al, 2012b). It is presumed that the sensory system influences the parasympathetic cranial ganglia, e.g.…”

“…It is presumed that the sensory system influences the parasympathetic cranial ganglia, e.g. the SPG, during the activation of the TS (Csati et al, 2012b).…”

Differentiation of Nerve Fibers Storing CGRP and CGRP Receptors in the Peripheral Trigeminovascular System

“…Recently, CGRP-positive fibers were demonstrated in the human sphenopalatine ganglion along with the CGRP receptor components. 3 These results suggest a possible sensory influence in the parasympathetic cranial ganglia. 3 …”

Role of VIP/PACAP in primary headaches

“…In a few migraine patients and in cluster headache there is release of VIP during the attacks, and this release seems to correlate with facial reddening (13,14). Recently, Csati et al provided evidence that there are sensory CGRP-containing nerve fibers (probably from the trigeminal ganglion) that project to the cranial parasympathetic ganglia and that there are CGRP receptor components (CLR, RAMP1) on satellite glial cells in the sphenopalatine ganglion (15). This provides evidence for an interaction between the parasympathetic and sensory systems.…”