Calcitonin-gene related peptide and cerebral vasospasm

Schebesch, Karl‐Michael; Herbst, Andreas; Bele, Sylvia; Schödel, Petra; Brawanski, Alexander; Stoerr, E.; Lohmeier, Annette; Kagerbauer, Simone Maria; Martin, Jan; Proescholdt, Martin

doi:10.1016/j.jocn.2012.07.006

Cited by 38 publications

(41 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This study showed that CGRP levels in CSF were markedly increased whereas the corresponding CGRP levels of a control group were not measurable. Likewise, we could show that CGRP was excessively released into CSF in 12 patients after aneurismal SAH compared to a control group (Schebesch et al, 2013b). During the first four days, the CGRP levels in CSF of the vasospasm group ranged significantly lower than the respective levels in the nonvasospasm group.…”

Section: Discussionmentioning

confidence: 69%

“…Described the functional antagonism of NPY and the vasodilator Calcitonin Gene-Related Peptide (CGRP) in mesenteric resistance arteries (De Mey et al, 2008). This antagonism had also been proposed to be present in the central nervous system and some research groups have evaluated the possible role of CGRP in SAH (Kokkoris et al, 2012;Juul et al, 1990;1995;Schebesch et al, 2013b).…”

Section: Ajnmentioning

confidence: 99%

See 1 more Smart Citation

Calcitonin Gene-Related Peptide in Serum After Spontaneous Subarachnoid Hemorrhage

Schebesch¹

2014

American Journal of Neuroscience

View full text Add to dashboard Cite

Endogenous Calcitonin Gene-Related Peptide (CGRP) stored in perivascular nerve fibers around the cerebral arteries mediates vasodilation and regulates cerebral blood flow under physiological conditions. Increased levels of CGRP have been continually reported in patients with migraine, but the role of CGRP in the pathophysiology of Subarachnoid Hemorrhage (SAH) has not yet been sufficiently evaluated. Over 10 days, serum was prospectively collected from 33 consecutive patients (17 women, 16 men; mean age 52.8 years) with spontaneous non-traumatic SAH. All patients were graded III or IV according to the Fisher Score. CGRP levels were determined by means of an Enzyme-Immunosorbent Assay (EIA). CGRP concentrations were correlated to (1) the anatomical localization of the aneurysm (anterior circulation or posterior circulation), (2) the treatment modality (clipped group, coiled group, or untreated group) and (3) the rate of ischemia determined by computed tomography (ischemia group, non-ischemia group, or iatrogenic ischemia group). (1) Anatomical localization: CGRP levels were significantly higher in patients with a ruptured aneurysm of the anterior circulation (p<0.001). (2) Treatment modality: CGRP levels differed significantly between the groups (coil group, clip group, or untreated group; p<0.001). The highest levels of CGRP were detected in the coil group and the lowest levels in the untreated group. About (3) Ischemia: CGRP levels differed significantly between the three groups (ischemia group, non-ischemia group, or iatrogenic ischemia group; p = 0.038). The highest levels of CGRP were found in the ischemia group. The maximum levels of CGRP in serum were found for patients with a ruptured aneurysm of the anterior circulation and subsequent ischemia treated by endovascular coiling. These findings support the theory that CGRP is produced and excessively released to counteract cerebral vasospasm and subsequent ischemia. Presumably, the serum levels of CGRP are affected by the anatomical localization of the aneurysm and can be stimulated by any endoluminal manipulation of the parent artery.

show abstract

Section: Discussionmentioning

confidence: 69%

Section: Ajnmentioning

confidence: 99%

Calcitonin Gene-Related Peptide in Serum After Spontaneous Subarachnoid Hemorrhage

Schebesch¹

2014

American Journal of Neuroscience

View full text Add to dashboard Cite

show abstract

“…Indeed, CSF CGRP levels were higher in patients without vasospasm than in those with vasospasm [44]. Moreover, in an experimental rat model, CGRP levels in the basilar artery were reduced after subarachnoid haemorrhage [65].…”

Section: Cgrp and [ 1 0 _ T D $ D I F F ] Cerebral [ 1 1 _ T D $ D I mentioning

confidence: 97%

“…As discussed below, CGRP has been shown to prevent the onset of hypertension [43], focal cerebral ischemia (by increasing blood flow [44,45]), and myocardial infarction and heart failure after cardiac ischemia [46,47].…”

Section: Cardiovascular Protective Role Of Cgrpmentioning

confidence: 99%

Wiping Out CGRP: Potential Cardiovascular Risks

MaassenVanDenBrink

Meijer

Villalón³

et al. 2016

Trends in Pharmacological Sciences

193

161

View full text Add to dashboard Cite

“…the trigeminal ganglia, the cortex, and the pituitary gland) and in white adipose tissue (WAT) (adipocytes, pre-adipocytes) [36][37][38]. Elevated levels of CGRP in migraine is explained by electrical stimulation of the TG of nerves, the release of CGRP and other peptides cause an increase in cerebral blood fluid, dilation of the cerebral vessels and the local release of pro-inflammatory mediators [39][40].…”

Section: Journal Of Headache and Pain Management Issn 2472-1913mentioning

confidence: 99%