Calcitonin gene-related peptide affords gastric mucosal protection by activating potassium channel in Wistar rat

Doi, Kosei; Nagao, Tetsuhiko; Kawakubo, K; Ibayashi, Setsuro; Aoyagi, Kazuhiko; Yano, Yuji; Yamamoto, Chizuko; Kanamoto, Kohki; Iida, Mitsuo; Sadoshima, Seizo; Fujishima, Masatoshi

doi:10.1016/s0016-5085(98)70634-1

Cited by 25 publications

(14 citation statements)

References 21 publications

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“…In the rat digestive system, CGRP fibers have been shown to be relatively rich in the stomach [11]. They have been shown to be particularly abundant around blood vessels, especially around the arterioles [11], a finding which is well consistent with the vasodilator action of CGRP [6, 7, 8]. Regarding the human stomach, there have been only a few studies on the distribution of CGRP; it was stated that CGRP fibers were rare.…”

Section: Discussionmentioning

confidence: 99%

“…There have been many studies in rats showing that capsaicin-sensitive nerves might participate in a gastric defense mechanism through a local release of CGRP [4, 5, 6, 7, 8, 16, 17]. It was reported that CGRP stimulated the proliferation of human endothelial cells and that the effect of CGRP may be important for the formation of new vessels during physiological events such as wound healing [18].…”

Section: Discussionmentioning

confidence: 99%

“…It has been proposed that capsaicin-sensitive nerves might participate in a gastric defense mechanism through a local release of CGRP, since CGRP has been shown to be a potent vasodilator in several studies [6, 7, 8]. …”

Section: Introductionmentioning

confidence: 99%

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Immunohistochemical Localization of Calcitonin Gene-Related Peptide in the Human Gastric Mucosa

Tani

Miyazawa²,

Miwa³

et al. 1999

Digestion

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Background/Aim: There have been only a few studies on the distribution of calcitonin gene-related peptide (CGRP) in the human stomach, in which it was stated that CGRP fibers are rare in that organ. The aim of the present study was to investigate the immunohistochemical localization of CGRP in the human gastric mucosa obtained by endoscopic biopsy from patients with gastric ulcers. Methods: Immunohistochemistry was carried out according to the indirect immunoperoxidase method using an anti-human CGRP antibody. Biopsies were taken from the ulcer margin in 18 patients (age 37–78, average 57.4 years) and from two endoscopically normal portions (antrum and body) in 7 other patients (age 36–65, average 51.0 years). One biopsy specimen was obtained from each portion. Results: Twelve of the eighteen biopsy specimens from the ulcer margin, 6 of the 7 biopsy specimens from normal portions of the antrum and 3 of the 7 biopsy specimens from normal portions of the body showed CGRP-immunoreactive staining. Intense staining was more marked in the specimens from the ulcer margin compared to those of the normal portions. Conclusions: CGRP immunoreactivity was observed in the human gastric mucosa in considerable abundance, and it is presumed that CGRP might participate in a restoration mechanism of the ulcer.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Immunohistochemical Localization of Calcitonin Gene-Related Peptide in the Human Gastric Mucosa

Tani

Miyazawa²,

Miwa³

et al. 1999

Digestion

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“…Protection by the latter is dependent on K + ATP channels partly. 70 An increase in plasma CGRP level caused by treatment with 164 µM capsaicin is found to protect the endothelium in rat aorta damaged by lysophosphotidyl choline and also reverse the vasoconstricting action of acetylcholine caused by the noxious agent. Desensitization reverses the effect.…”

Section: Protection By (I) Capsaicinmentioning

confidence: 99%

“…counters the effect of the former and also reverses the protective effect at least in part of CGRP against lesions induced by acidic ethanol. 70 Among CGRP, NKA and SP present in c.s. nerves NKA is also released by capsaicin.…”

Section: Role Of Cgrpmentioning

confidence: 99%

Capsaicin and Gastric Ulcers

2006

Critical Reviews in Food Science and Nutrition

106

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In recent years, infection of the stomach with the organism Helicobacter Pylori has been found to be the main cause of gastric ulcers, one of the common ailments afflicting humans. Excessive acid secretion in the stomach, reduction in gastric mucosal blood flow, constant intake of non-steroid anti-inflammatory drugs (NSAIDS), ethanol, smoking, stress etc. are also considered responsible for ulcer formation. The prevalent notion among sections of population in this country and perhaps in others is that "red pepper" popularly known as "Chilli," a common spice consumed in excessive amounts leads to "gastric ulcers" in view of its irritant and likely acid secreting nature. Persons with ulcers are advised either to limit or avoid its use. However, investigations carried out in recent years have revealed that chilli or its active principle "capsaicin" is not the cause for ulcer formation but a "benefactor." Capsaicin does not stimulate but inhibits acid secretion, stimulates alkali, mucus secretions and particularly gastric mucosal blood flow which help in prevention and healing of ulcers. Capsaicin acts by stimulating afferent neurons in the stomach and signals for protection against injury causing agents. Epidemiologic surveys in Singapore have shown that gastric ulcers are three times more common in the "Chinese" than among Malaysians and Indians who are in the habit of consuming more chillis. Ulcers are common among people who are in the habit of taking NSAIDS and are infected with the organism "Helicobacter Pylori," responsible for excessive acid secretion and erosion of the mucosal layer. Eradication of the bacteria by antibiotic treatment and avoiding the NSAIDS eliminates ulcers and restores normal acid secretion.

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