Calcite as a bone substitute. Comparison with hydroxyapatite and tricalcium phosphate with regard to the osteoblastic activity

Monchau, F.; Hivart, P.; Genestie, B.; Chai, Feng; Descamps, M.; Hildebrand, Hartmut F.

doi:10.1016/j.msec.2012.09.019

Cited by 59 publications

(39 citation statements)

References 22 publications

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“…However, the detailed study on cell behaviors of calcium carbonate as bone graft is rarely reported. The results of comparative study of cell proliferation on CC, HA, and β-TCP were in agreement with the work by Monchau et al [15] who fabricated porous calcium carbonate ceramic at a high temperature (890°C) under the CO 2 atm, and found that the cell activity on porous calcium carbonate ceramic was incomparable with that on β-TCP and HA ceramics. On the contrary, the CC prepared in the study was fast sintered at a much lower temperature (650°C), which avoided significant decomposition of calcium carbonate but could not obtain considerable compressive strength.…”

Section: Discussionsupporting

confidence: 91%

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In vitro degradation and cell response of calcium carbonate composite ceramic in comparison with other synthetic bone substitute materials

Zhang

Yang

et al. 2015

Materials Science and Engineering: C

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Section: Discussionsupporting

confidence: 91%

“…Even so, calcium carbonate ceramics can be acquired by various methods such as sintering under the CO 2 atmosphere, carbonation of calcium hydroxide compacts, introducing lithium carbonate as sintering additive, etc. [15][16][17].…”

Section: Introductionmentioning

confidence: 99%

In vitro degradation and cell response of calcium carbonate composite ceramic in comparison with other synthetic bone substitute materials

Zhang

Yang

et al. 2015

Materials Science and Engineering: C

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“…Firstly, the greater presence of β‐TCP phase in the scaffolds sintered at 1300°C might reduce cell proliferation. Indeed, Monchau et al . reported that β‐TCP induces lower proliferation than HA on MC3T3‐E1 cells after 6 days.…”

Section: Resultsmentioning

confidence: 99%

Effect of the drying process on the compressive strength and cell proliferation of hydroxyapatite‐derived scaffolds

Martínez‐Vázquez

Pajares

Miranda

2017

Int J Applied Ceramic Tech

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The compressive strength and MC3T3 cell proliferation response of robocast hydroxyapatite‐derived scaffolds was evaluated for samples fabricated by conventional and freeze‐drying methods followed by sintering at 1100 or 1300°C. Both the sintering temperature and, especially, the drying method affected significantly the size and morphology of the residual microporosity within the robocast scaffold's struts. The freeze‐drying method generated a persistent large (1‐10 μm) microporosity of dendritic morphology that was found to improve the biological response of hydroxyapatite‐derived scaffolds. Conversely, conventional drying enhances the compressive strength of the structures. Strength was also increased at the higher sintering temperature, although at the expense of a poorer cell proliferation behavior. The results of this study suggest that the use of a freeze drying process after printing by robocasting provides a very appropriate method for enhancing the biological performance and reliability of bioceramic robocast scaffolds without severely reducing their compressive strength. And, thus, shows promise as an effective method to optimize the performance of robocast scaffolds for bone tissue regeneration.

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“…The use of hydroxyapatite (HAp) and/or other calcium orthophosphates (CPs) presents a standard approach to endowing a bone graft with sufficient bioactivity and compressive strength 8 . Out of a dozen different CP phases, HAp presents a typical phase of choice because of its being the least soluble 9 , the most bioactive 10 and the most mechanically stable 11 of them all, alongside being the natural mineral component of mammalian hard tissues. Pure CP grafts can also be made in a self-setting form, viscous upon the implantation or injection and hardening thereafter 12 .…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial hydroxyapatite–gelatin–silica composite pastes with tunable setting properties

Uskoković

Ghosh

2017

J. Mater. Chem. B

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Bone grafting is one of the commonest surgical procedures, yet all bone substitutes developed so far suffer from specific weaknesses and the search for a bone graft material with ideal physical and biological properties is still ongoing. Calcium phosphate pastes are the most frequently used synthetic bone grafts, yet they (a) often take an impractically long time to set, (b) release the drug content too fast, and (c) do not form pores large enough to accommodate host cells and foster osseointegration. To make up for these deficiencies, we introduced gelatin and silica to pastes composed of 5–15 nm sized hydroxyapatite nanoparticles and yielded a bioresorbable composite that is compact, yet flowing upon injection; that prevents setting at room temperature, but sets promptly, in minutes, at 37 °C; that displays an increase in surface porosity following immersion in physiological fluids; that allows for sustained release of antibiotics; and that sets in a tunable manner and in clinically relevant time windows: 1–3 minutes at its fastest. Timelapse, in situ X-ray diffraction analysis demonstrated that the setting process is accompanied by an increase in crystallinity of the initially amorphous hydroxyapatite, involving no polymorphic phase transitions in its course. Setting time can be tuned by controlling the weight content of gelatin or powder-to-liquid ratio. The release of vancomycin was slow, ~ 8 % after 2 weeks, and unaffected by the gelatin content. While vancomycin-loaded pastes were effective in reducing the concentration of all bacterial species analyzed, the bacteriostatic effects of the antibiotic-free pastes were pronounced against S. liquefaciens and E. coli. S. liquefaciens bacilli underwent beading and filamentation during the treatment, suggesting that the antimicrobial effects are attributable to cell wall disruption by hydroxyapatite nanoparticles. Vancomycin-loaded pastes augmented the activity of the antibiotic against P. aeruginosa and S. liquefaciens, while exhibiting no negative effects against human mesenchymal stem cells. They were also uptaken three times more abundantly than pure hydroxyapatite, indicating the theoretical favorability of their use for intracellular delivery of therapeutics. This selectivity, toxic for bacteria and harmless for primary stem cells, is promising for application as bone grafts for osteomyelitis.

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Calcite as a bone substitute. Comparison with hydroxyapatite and tricalcium phosphate with regard to the osteoblastic activity

Cited by 59 publications

References 22 publications

In vitro degradation and cell response of calcium carbonate composite ceramic in comparison with other synthetic bone substitute materials

In vitro degradation and cell response of calcium carbonate composite ceramic in comparison with other synthetic bone substitute materials

Effect of the drying process on the compressive strength and cell proliferation of hydroxyapatite‐derived scaffolds

Antimicrobial hydroxyapatite–gelatin–silica composite pastes with tunable setting properties

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