“…The delay between topical application and UV irradiation varies among studies, potentially influencing the MED. In brief, calcipotriol 0.005% [23][24][25][26][27] applied 15-20 min [25,27] or immediately before [23,24,26] irradiation, with a thick enough layer [23] , influenced the MED [23][24][25][26][27] , which could reach an increase of 31% [27] or an increase from 22.6 to 54.6 mJ/cm 2 [23] . Two hours after application, the MED returned to baseline [26] .…”