Calciphylaxis in a patient with acute kidney injury and alcoholic cirrhosis

Wichienkuer, Promporn Paula; Naugler, Willscott E.; Wusirika, Raghav

doi:10.5414/cn106781

Cited by 5 publications

(2 citation statements)

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“…2,11 Limited cases have been reported on calciphylaxis in patients with AKI due to decompensated alcoholic cirrhosis or severe clinical conditions such as necrotizing fasciitis who undergo dialysis, ranging from 29 to 65 years. [13][14][15][16][17] However, there are no documented reports of patients with lupus neph ritis with significant kidney damage who had calciphylaxis.…”

Section: Discussionmentioning

confidence: 99%

Calciphylaxis in a Patient With Lupus Nephritis and Acute Kidney Injury: A Rare Case Report and Literature Review

Gholizadeh Ghozloujeh,

Rajasekaran,

Abdipour

et al. 2023

Journal of Investigative Medicine High Impact Case Reports

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Calciphylaxis is a rare and severe disease characterized by calcification, fibrosis, and thrombosis of small blood vessels. Although it primarily affects patients with end-stage renal disease (ESRD) on dialysis, limited cases have been reported of calciphylaxis in patients with acute kidney injury (AKI) and lupus. This case report describes the occurrence of calciphylaxis in a 35-year-old female recently diagnosed with lupus nephritis class IV and AKI requiring dialysis.

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Section: Discussionmentioning

confidence: 99%

Calciphylaxis in a Patient With Lupus Nephritis and Acute Kidney Injury: A Rare Case Report and Literature Review

Gholizadeh Ghozloujeh,

Rajasekaran,

Abdipour

et al. 2023

Journal of Investigative Medicine High Impact Case Reports

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“…It is unknown whether the CMV mechanisms implied in other vasculitis processes such as direct cell injury, immunemediated injury and/or increase pro-coagulant activity, could be responsible for the endothelial damage observe in CUA. Few cases of CUA have been reported in patients with liver disease (11)(12)(13)(14)(15)(16)(17). In those reports, CUA present in patients with alcoholic cirrhosis and normal renal function; only one patient had acute kidney injury (17).…”

Section: Discussionmentioning

confidence: 99%

Calciphylaxis in Simultaneous Liver–Kidney Transplantation

Bohórquez

Chamorro

Garces

et al. 2015

American Journal of Transplantation

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We present four patients who underwent simultaneous liver-kidney transplantation (SLK) and were diagnosed with calciphylaxis, also known as calcific uremic arteriolopathy (CUA). Common characteristics included high MELD scores (mean 35.2 AE 4.8) and advanced renal disease (duration range 6-44 weeks). CUA was diagnosed within the first 2 months post-SLK based on clinical features. Severe morbidity and prolonged hospital stay were observed and one of the patients died secondary to sepsis. Treatment included metabolic support, wound care, calcium level correction and use of sodium thiosulphate. CUA should be considered in the presence of painful dermatologic changes in patients status post SLK.

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