Calciphylaxis and its co‐occurrence with connective tissue diseases

Zhou, Yueyuan; Chen, Yuehong; Yin, Geng; Xie, Qibing

doi:10.1111/iwj.13972

Cited by 4 publications

(3 citation statements)

References 129 publications

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“…The focus of management primarily revolves around local wound care and preventing both local and systemic infections. At the same time, efforts are directed towards optimizing medical therapy for any associated comorbidities [ 9 , 10 ].…”

Section: Discussionmentioning

confidence: 99%

A Peculiar Presentation of a Debilitating Condition: Calciphylaxis

Apostol,

Cojocaru,

Ion

et al. 2024

Cureus

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Calciphylaxis is a debilitating condition associated with significant morbidity and mortality, often associated with patients with end-stage renal disease, in which the calcification of cutaneous arterioles and small arteries occurs, leading to subsequent ischemia and cutaneous infarction. Herein, we report the case of a diabetic patient with end-stage kidney disease on dialysis, presenting multiple intensely painful necrotic plaques on the lower extremities. The suspicion of calciphylaxis was raised based on the patient's medical history and clinical presentation, subsequently confirmed by radiological examination, which revealed calcifications along vascular pathways. Diagnosis can be established based on clinical and paraclinical grounds alone, and some clinicians may forego skin biopsy and initiate treatment presumptively. The management of calciphylaxis remains a challenge and requires a multidisciplinary approach since most patients experience intense pain that is often unresponsive to conventional analgesics, leading to a reduced quality of life.

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Section: Discussionmentioning

confidence: 99%

A Peculiar Presentation of a Debilitating Condition: Calciphylaxis

Apostol,

Cojocaru,

Ion

et al. 2024

Cureus

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“…Calciphylaxis is a serious medical condition with an insidious onset, with a male-to-female ratio of incidence being 12:1, and commonly affects the skin of the legs, followed by toes, fingers, abdomen, buttocks, and penis [8]. It has been frequently associated with end-stage renal disease; however, there have been sporadic cases of non-uremic calciphylaxis.…”

Section: Discussionmentioning

confidence: 99%

Calciphylaxis: An Unusual and Silent Usher for an Underlying Carcinoma

Vijaya Prakash,

Srinivasan Kumar,

Veulens

2023

Cureus

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Calciphylaxis is an uncommon but serious and potentially life-threatening painful condition that is characterized by cutaneous vascular calcification and ischemia. It is typically seen in patients with endstage renal disease but has been known to occur less commonly in patients with normal renal function. A rare but established etiology of non-uremic calciphylaxis is malignancy. We have thus far been successful in documenting an association between calciphylaxis and certain solid tumor types. The objective of this clinical case study is to better define a possible association between calciphylaxis and underlying malignancy.

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“…Calciphylaxis or calcific uremic arteriolopathy [ 1 ] is a rare but highly morbid complication associated with chronic kidney disease (CKD) [ 2–4 ] that affects about 1% of hemodialysis (HD) patients [ 5–8 ]. It is characterized by medial calcification of cutaneous arterioles in the subcutaneous tissue resulting from calcium deposition in microvasculature [ 2 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

Multimodality approach to treat calciphylaxis in end-stage kidney disease patients

Lajoie,

Ghanemi,

Bourbeau

et al. 2023

Renal Failure

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A multimodality approach has been proposed as an effective treatment for calciphylaxis in patients with end-stage kidney disease. In this retrospective study, we report the cases of 12 end-stage kidney disease patients from l’Hôtel-Dieu de Québec hospital (Canada) who were diagnosed with calciphylaxis between 2004 and 2012 and treated with a multimodality clinical approach including sodium thiosulfate (STS). Statistical analyses were performed to evaluate the impacts of patients characteristics, the different interventions as well as therapy regimen on the therapeutic response. The majority of patients ( n = 9) were hemodialyzed. The patients-associated comorbidities were consistent with previously reported risk factors for calciphylaxis: Diabetes ( n = 11), calcium-based phosphate binders use ( n = 10), warfarin use ( n = 9), obesity ( n = 7), female gender ( n = 8) and intravenous iron use ( n = 8). STS was given for a median duration of 81 days. 75% of the patients had a response (total or partial) including a complete response in 42% of patients. One-year mortality rate was low (25%). STS was used during a mean duration of 83.33 ± 41.52 days and with a total cumulating dose of 1129.00 ± 490.58 g. The recorded mean time before a complete response was 102.20 days (51–143). Pain improvement occurred after a mean time of 8.67 ± 10.06 days. None of the studied factors was statistically associated with a complete or a partial response to the multimodality approach. Although our data have a limited statistical power, they support treating calciphylaxis with a multimodality approach including STS as its effects are independent from important clinical variables.

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Calciphylaxis and its co‐occurrence with connective tissue diseases

Cited by 4 publications

References 129 publications

A Peculiar Presentation of a Debilitating Condition: Calciphylaxis

A Peculiar Presentation of a Debilitating Condition: Calciphylaxis

Calciphylaxis: An Unusual and Silent Usher for an Underlying Carcinoma

Multimodality approach to treat calciphylaxis in end-stage kidney disease patients

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