Calciphylaxis, A Poorly Understood Clinical Syndrome: Three Case Reports and a Review of the Literature

Howe, S.C.; Murray, Jay; Reeves, R.T.; Hemp, James; Carlisle, J.H.

doi:10.1007/s100160010122

Cited by 24 publications

(10 citation statements)

References 7 publications

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“…[58][59][60] It is a relatively common problem in patients undergoing hemodialysis, with reports of prevalence as high as 4.1%. 60 Cutaneous lesions often begin as LR that progresses to cutaneous ulcers, necrosis, and gangrene, which may necessitate amputation.…”

Section: Autoimmunementioning

confidence: 99%

Livedo reticularis: An update

Gibbs

English

Zirwas

2005

Journal of the American Academy of Dermatology

120

121

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Section: Autoimmunementioning

confidence: 99%

Livedo reticularis: An update

Gibbs

English

Zirwas

2005

Journal of the American Academy of Dermatology

120

121

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“…Challenging agents include metallic salts, local trauma, certain organic compounds (albumin and egg yolk), corticosteroids, intramuscular iron dextran complex, calcium heparinate, and intramuscular tobramycin. The sensitizing event and the challenging insult don't have to occur at the same time to cause disease (10,17). Patients with diabetes and chronic renal failure have a much higher risk of developing acral gangrene (16).…”

Section: Discussionmentioning

confidence: 99%

“…Hyperbaric oxygen therapy and administration of prednisone, cimetidine, and systemic corticosteroids have been suggested as medical management (1,7,10). Intensive wound care, administration of antibiotics, debridement of necrotic tissue, corrections of electrolytes are most important factors in preventing sepsis (10,12,18). Death is usually caused by uncontrollable sepsis after infection of the chronic ulcerations.…”

Section: Discussionmentioning

confidence: 99%

Calciphylaxis Involving Both the Upper and Lower Extremities

Özer

Borazan

Hoşnuter

et al. 2004

Acta Med. (Hradec Kralove, Czech Repub.)

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Calciphylaxis is an uncommon complication of end stage renal disease (ESRD) and secondary hyperparathyroidism. It characterized by cutaneous necrosis with mural calcifications and thrombosis in the small vessels of dermis. It is important to diagnose and treat, because of mortality rate from calciphylaxis is very high. We present the case of a patient with ESRD and type II diabetes mellitus developing calciphylaxis of the both upper and lower extremities had normal corrected calcium-phosphate product level. After amputation, necrosis was showed rapid progression resulting in death in one month.

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“…Calciphylaxis can occur in those with high or normal levels of serum calcium and phosphate, with or without vitamin D replacement, less often in those who have received a renal transplant. 2,37 ENREF 37 Skin biopsy shows calcium deposition in and around the blood vessel walls, but the histology is highly variable. Calciphylaxis may begin as microlivedo and eventually lead to tissue necrosis (Fig 4d).…”

Section: 0 Cutaneous Microthrombic Ulcersmentioning

confidence: 99%

Connective tissue ulcers

Dabiri

Falanga

2013

Journal of Tissue Viability

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Connective tissue disorders (CTD), which are often also termed collagen vascular diseases, include a number of related inflammatory conditions. Some of these diseases include rheumatoid arthritis, systemic lupus erythematosus, systemic sclerosis (scleroderma), localized scleroderma (morphea variants localized to the skin), Sjogren’s syndrome, dermatomyositis, polymyositis, and mixed connective tissue disease. In addition to the systemic manifestations of these diseases, there are a number of cutaneous features that make these conditions recognizable on physical exam. Lower extremity ulcers and digital ulcers are an infrequent but disabling complication of long-standing connective tissue disease. The exact frequency with which these ulcers occur is not known, and the cause of the ulcerations is often multifactorial. Moreover, a challenging component of CTD ulcerations is that there are still no established guidelines for their diagnosis and treatment. The morbidity associated with these ulcerations and their underlying conditions is very substantial. Indeed, these less common but intractable ulcers represent a major medical and economic problem for patients, physicians and nurses, and even well organized multidisciplinary wound healing centers.

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Calciphylaxis, A Poorly Understood Clinical Syndrome: Three Case Reports and a Review of the Literature

Cited by 24 publications

References 7 publications

Livedo reticularis: An update

Livedo reticularis: An update

Calciphylaxis Involving Both the Upper and Lower Extremities

Connective tissue ulcers

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