Calciphylaxie chez l’insuffisant rénal dialysé : 8 malades traités par thiosulfate de sodium

Devey, S.; Valois, A.; Cazajous, G.; Beaume, Julie Morinière; Abed, S.; Okhremchuk, I.; Spadoni, S.; Boyé, T.; Jj, Morand

doi:10.1016/j.annder.2018.02.002

Cited by 7 publications

(4 citation statements)

References 12 publications

(13 reference statements)

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“…More than 350 cases with the use of STS in CP patients have been reported so far, 44 either with STS alone or as part of a combination therapy. Positive effects were seen in CP patients with renal disease/dialysis 45 as well as in non-uremic CP cases 46 where the therapeutic effect cannot be explained so far. Even intralesional injections have been described occasionally 47 and showed a good clinical improvement but pain during injections.…”

Section: Systemic Treatmentmentioning

confidence: 97%

<p>Management of patients with calciphylaxis: current perspectives</p>

Erfurt‐Berge¹,

Renner²

2019

CWCMR

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Calciphylaxis (CP) is a rare disorder presenting with painful ischemic skin ulcerations. Its association with end-stage renal disease, but also non-uremic cases have been described. Several risk factors, like metabolic syndrome, calcium-phosphate imbalance, anticoagulative medication and female gender have been discussed. Multidisciplinary therapeutic approaches are necessary since evidence-based guidelines are missing due to lack of pathophysiological understanding of the disease and the absence of studies with large patient cohorts. However, strategies for local wound therapy, reduction of risk factors and systemic therapies are being developed. Changes in duration, frequency and method of hemodialysis and specific medication to lower the calcium upload can be effective in uremic CP cases. Systemic treatments with cinacalcet, sodium thiosulfate or bisphosphonates have been applied successfully in CP patients, but large placebo-controlled randomized trials are still needed to gather better insight into this fatal disease.

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Section: Systemic Treatmentmentioning

confidence: 97%

<p>Management of patients with calciphylaxis: current perspectives</p>

Erfurt‐Berge¹,

Renner²

2019

CWCMR

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“…Another interesting compound for the treatment of calciphylaxis is sodium thiosulfate. This was originally developed for the treatment of acute cyanide poisoning, but there are several published case series on its successful use in calciphylaxis patients 76,77 Any treatment decision on medical intervention in the calcium metabolism in patients with calciphylaxis should be made in an interdisciplinary setting.…”

Section: Calciphylaxismentioning

confidence: 99%

Occlusive cutaneous vasculopathies as cause of chronic ulcers

Ronicke,

Berking,

Erfurt‐Berge

2024

J Deutsche Derma Gesell

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SummaryThe term occluding vasculopathies covers a large number of different conditions. These often manifest as skin ulcers. Occluding vasculopathies should be considered in the differential diagnosis of leg ulcers. The term “occlusive vasculopathies” encompasses pathophysiologically related entities that share structural or thrombotic obliteration of small cutaneous vessels. In this article, we will focus on livedoid vasculopathy with and without antiphospholipid syndrome and calciphylaxis with differentiation from hypertonic leg ulcer as the most relevant differential diagnoses of leg ulcer. The term also includes vascular occlusion, for example due to oxalate or cholesterol embolism, and septic vasculopathy. This often leads to acral ulceration and is therefore not a differential diagnosis with classic leg ulcers. It will not be discussed in this article.Occlusive vasculopathy may be suspected in the presence of the typical livedo racemosa or (non‐inflammatory) retiform purpura as a sign of reduced cutaneous perfusion in the wound area. Inflammatory dermatoses, especially vasculitides, must be differentiated. This is achieved by histopathological evaluation of a tissue sample of sufficient size and depth taken at the appropriate time. In addition, specific laboratory parameters, particularly coagulation parameters, can support the diagnosis.

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“…Eine weitere interessante Substanz zur Behandlung der Calciphylaxie ist Natriumthiosulfat. Ursprünglich zur Behandlung akuter Cyanidvergiftungen eingesetzt, wurden mehrere Fallserien mit erfolgreicher Anwendung bei Patienten mit Calciphylaxie veröffentlicht 76,77 Die Therapieentscheidung über eine medikamentöse Beeinflussung des Kalzium‐Haushaltes bei Patienten mit Kalziphylaxie sollte interdisziplinär erfolgen.…”

Section: Calciphylaxieunclassified

Okkludierende kutane Vaskulopathien als Ursachen chronischer Unterschenkelulzerationen

Ronicke,

Berking,

Erfurt‐Berge

2024

J Deutsche Derma Gesell

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ZusammenfassungUnter den Begriff der okkludierenden Vaskulopathien fällt eine Reihe unterschiedlicher Krankheitsbilder. Diese manifestieren sich an der Haut häufig mit Ulzerationen. Gerade bei Ulzerationen der Unterschenkel sollten okkludierende Vaskulopathien in die differenzialdiagnostischen Überlegungen einbezogen werden. Der Begriff „okkludierende Vaskulopathien“ umfasst pathophysiologisch verwandte Entitäten, die eine strukturelle oder thrombotische Obliteration von kleinsten Hautgefäßen gemein haben. In diesem Artikel wird vor allem auf die Livedovaskulopathie mit und ohne Antiphospholipidsyndrom sowie die Calciphylaxie mit Abgrenzung zum Ulcus cruris hypertonicum als die relevantesten Differenzialdiagnosen von Unterschenkelulzerationen eingegangen. Der Begriff umfasst auch Gefäßverschlüsse, beispielsweise durch Oxalat oder Cholesterinembolie, sowie die septische Vaskulopathie. Diese führt häufig zu akralen Ulzerationen und stellt somit keine Differenzialdiagnose zum klassischen Ulcus cruris dar. Sie wird daher in diesem Artikel nicht behandelt.Der Verdacht einer okkludierenden Vaskulopathie kann über die typische Livedo racemosa beziehungsweise die (nichtinflammatorische) retiforme Purpura als Zeichen der kutanen Minderdurchblutung in der Wundumgebung gestellt werden. Entzündliche Dermatosen, insbesondere Vaskulitiden, müssen differenzialdiagnostisch abgegrenzt werden. Dies geschieht zum Teil klinisch und durch die histopathologische Beurteilung einer Gewebeprobe, die in ausreichender Größe und Tiefe sowie zum richtigen Zeitpunkt entnommen werden muss. Ergänzend können spezifische Laborparameter, insbesondere die Gerinnungsdiagnostik, die Diagnosestellung unterstützen.

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Calciphylaxie chez l’insuffisant rénal dialysé : 8 malades traités par thiosulfate de sodium

Abstract: LETTRE À LA RÉDACTION Calciphylaxie chez l'insuffisant rénal dialysé : 8 malades traités par thiosulfate de sodium Calciphylaxis in hemodialysis patients: 8 cases treated with sodium thiosulfate * Auteur correspondant.

Cited by 7 publications

References 12 publications

<p>Management of patients with calciphylaxis: current perspectives</p>

<p>Management of patients with calciphylaxis: current perspectives</p>

Occlusive cutaneous vasculopathies as cause of chronic ulcers

Okkludierende kutane Vaskulopathien als Ursachen chronischer Unterschenkelulzerationen

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