Calciotropic and phosphotropic hormones in fetal and neonatal bone development

Ryan, Brittany A.; Kovacs, Christopher S.

doi:10.1016/j.siny.2019.101062

Cited by 23 publications

(22 citation statements)

References 54 publications

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“…In the nongravid state, P i homeostasis is regulated through multi-system endocrine signaling in conjunction with calcium via systemic activity of phosphatonins including parathyroid hormone (PTH), vitamin D (VD), and fibroblast growth factor 23 (FGF23). The parathyroid gland responds to decreased calcium levels and regulates PTH secretion which increases blood calcium levels by stimulating release of calcium and P i from bone, as well as altering calcium reabsorption, P i excretion, and VD production by the kidney, which in turn increases intestinal reabsorption [4][5][6][7][8]. FGF23 signaling downregulates P i transporter gene expression and inhibits production of VD and PTH [4,5].…”

Section: Introductionmentioning

confidence: 99%

“…The parathyroid gland responds to decreased calcium levels and regulates PTH secretion which increases blood calcium levels by stimulating release of calcium and P i from bone, as well as altering calcium reabsorption, P i excretion, and VD production by the kidney, which in turn increases intestinal reabsorption [4][5][6][7][8]. FGF23 signaling downregulates P i transporter gene expression and inhibits production of VD and PTH [4,5]. During fetal development, placental mineral transport and micronutrient accretion is regulated in part by PTH-related protein (PTHrP) and possibly PTH, but not by calcitriol, FGF23, calcitonin, or the sex steroids [5].…”

Section: Introductionmentioning

confidence: 99%

“…FGF23 signaling downregulates P i transporter gene expression and inhibits production of VD and PTH [4,5]. During fetal development, placental mineral transport and micronutrient accretion is regulated in part by PTH-related protein (PTHrP) and possibly PTH, but not by calcitriol, FGF23, calcitonin, or the sex steroids [5]. In the fetus, fetal kidneys and fetal membranes contribute to production and regulation of amniotic fluid and P i can undergo several routes [5,9].…”

Section: Introductionmentioning

confidence: 99%

“…During fetal development, placental mineral transport and micronutrient accretion is regulated in part by PTH-related protein (PTHrP) and possibly PTH, but not by calcitriol, FGF23, calcitonin, or the sex steroids [5]. In the fetus, fetal kidneys and fetal membranes contribute to production and regulation of amniotic fluid and P i can undergo several routes [5,9]. At least five pathways of exchange have been identified between the amniotic space and the surrounding tissues, indicating multiple routes by which P i can be exchanged between amniotic fluid and the developing fetus, where the large majority of P i undergoes accretion and plays a crucial role in skeletal ossification during the latter half of pregnancy [9].…”

Section: Introductionmentioning

confidence: 99%

“…At least five pathways of exchange have been identified between the amniotic space and the surrounding tissues, indicating multiple routes by which P i can be exchanged between amniotic fluid and the developing fetus, where the large majority of P i undergoes accretion and plays a crucial role in skeletal ossification during the latter half of pregnancy [9]. In nonpathological conditions, fetal serum P i levels are maintained approximately 0.5 mmol/L higher than in the mother [5].…”

Section: Introductionmentioning

confidence: 99%

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Inorganic Phosphate in the Pathogenesis of Pregnancy-Related Complications

Correia-Branco

Rincón²,

Pereira³

et al. 2020

IJMS

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Inorganic phosphate (Pi) is an essential nutrient that fulfills critical roles in human health. It enables skeletal ossification, supports cellular structure and organelle function, and serves key biochemical roles in energetics and molecular signaling. Pi homeostasis is modulated through diet, intestinal uptake, renal reabsorption, and mobilization of stores in bone and extracellular compartments. Disrupted Pi homeostasis is associated with phosphate wasting, mineral and bone disorders, and vascular calcification. Mechanisms of Pi homeostasis in pregnancy remain incompletely understood. The study presented herein examined biological fluid Pi characteristics over the course of gestation. Correlations with gestation age, pregnancy number, preterm birth, preeclampsia, diabetes mellitus, and placental calcification were evaluated during the last trimester. The results support that maternal urinary Pi levels increased during the third trimester of pregnancy. Reduced levels were observed with previous pregnancy. Amniotic fluid Pi levels decreased with gestation while low second trimester levels associated with preterm birth. No significant difference in urinary Pi levels was observed between preeclampsia and controls (8.50 ± 2.74 vs. 11.52 ± 2.90 mmol/L). Moreover, increased maternal urinary Pi was associated with preexisting diabetes mellitus in preeclampsia. Potential confounding factors in this study are maternal age at delivery and body mass index (BMI)—information which we do not have access to for this cohort. In conclusion, Pi levels provide clinical information regarding the pathogenesis of pregnancy-related complications, supporting that phosphate should be examined more closely and in larger populations.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Inorganic Phosphate in the Pathogenesis of Pregnancy-Related Complications

Correia-Branco

Rincón²,

Pereira³

et al. 2020

IJMS

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Pleckstrin homology (PH) domain and Leucine Rich Repeat Phosphatase 1 (Phlpp1) Suppresses Parathyroid Hormone Receptor 1 (Pth1r) Expression and Signaling During Bone Growth

Weaver

Taylor

Zars

et al. 2020

Journal of Bone and Mineral Research

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Endochondral ossification is tightly controlled by a coordinated network of signaling cascades including parathyroid hormone (PTH). Pleckstrin homology (PH) domain and leucine rich repeat phosphatase 1 (Phlpp1) affects endochondral ossification by suppressing chondrocyte proliferation in the growth plate, longitudinal bone growth, and bone mineralization. As such, Phlpp1−/− mice have shorter long bones, thicker growth plates, and proportionally larger growth plate proliferative zones. The goal of this study was to determine how Phlpp1 deficiency affects PTH signaling during bone growth. Transcriptomic analysis revealed greater PTH receptor 1 (Pth1r) expression and enrichment of histone 3 lysine 27 acetylation (H3K27ac) at the Pth1r promoter in Phlpp1‐deficient chondrocytes. PTH (1‐34) enhanced and PTH (7‐34) attenuated cell proliferation, cAMP signaling, cAMP response element‐binding protein (CREB) phosphorylation, and cell metabolic activity in Phlpp1‐inhibited chondrocytes. To understand the role of Pth1r action in the endochondral phenotypes of Phlpp1‐deficient mice, Phlpp1−/− mice were injected with Pth1r ligand PTH (7‐34) daily for the first 4 weeks of life. PTH (7‐34) reversed the abnormal growth plate and long‐bone growth phenotypes of Phlpp1−/− mice but did not rescue deficits in bone mineral density or trabecular number. These results show that elevated Pth1r expression and signaling contributes to increased proliferation in Phlpp1−/− chondrocytes and shorter bones in Phlpp1‐deficient mice. Our data reveal a novel molecular relationship between Phlpp1 and Pth1r in chondrocytes during growth plate development and longitudinal bone growth. © 2021 American Society for Bone and Mineral Research (ASBMR).

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Effect of birth type and sex on growth performance, wither height, humerus‐radius bone dimensions, humerus–ulna growth plate width and selected hormone profile in growing Gurcu goat kids

Boğa Kuru,

Akyüz,

Aydın

et al. 2024

Veterinary Medicine & Sci

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ObjectivesIn this study, the effects of sex and birth type on growth performance, withers height (WH), radiographic measurements and selected hormone profiles in Gurcu goat kids were investigated.MethodsTwenty kids (single female = 5, single male = 5, twin female = 5, twin male = 5) were included in the study. Body weight (BW), WH, radiographic measurements (humerus length [HL], radius length [RL], proximal humerus epiphyseal plate width [HEP] and distal ulna epiphyseal plate width [UEP]) and biochemical analysis (for serum calcitonin, free triiodothyronine [FT3], free thyroxine [FT4], growth hormone [GH] and insulin‐like growth factor‐I [IGF‐I]) were performed at 1, 3, 5, 7, 9 and 12 months of age.ResultsBW was significantly higher in males starting from the seventh month compared to females (p < 0.05). HL was higher in males at seventh (p = 0.009) and ninth (p = 0.033) months, whereas RL was lower in twins at the third month (p = 0.021). UEP was wider in males at seventh (p = 0.008) and ninth (p = 0.036) months. Closure of HEP was observed in 65% of kids by the 12th month. Calcitonin was lower in twins at third (p = 0.045) and fifth (p = 0.006) months, with changes observed due to group and time effects (p < 0.05), whereas other hormones only changed with time (p < 0.05). Positive correlations were observed between BW, WH, HL, RL and IGF‐I. There was a negative correlation between BW, WH, HL, RL, IGF‐I and HEP, UEP, calcitonin, FT3, FT4, GH.ConclusionSex and birth type in Gurcu goat kids may have an impact on growth performance, radiographic measurements and certain hormonal profiles.

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Calciotropic and phosphotropic hormones in fetal and neonatal bone development

Cited by 23 publications

References 54 publications

Inorganic Phosphate in the Pathogenesis of Pregnancy-Related Complications

Inorganic Phosphate in the Pathogenesis of Pregnancy-Related Complications

Pleckstrin homology (PH) domain and Leucine Rich Repeat Phosphatase 1 (Phlpp1) Suppresses Parathyroid Hormone Receptor 1 (Pth1r) Expression and Signaling During Bone Growth

Effect of birth type and sex on growth performance, wither height, humerus‐radius bone dimensions, humerus–ulna growth plate width and selected hormone profile in growing Gurcu goat kids

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