Calcinosis universalis in systemic sclerosis

Alhassan, Eaman

doi:10.1002/acr2.11527

Cited by 1 publication

(1 citation statement)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In these cases, a strict follow-up is required to lower the risk of complications such as infections and fistulation. Extensive diffuse calcifications (calcinosis cutis universalis) accumulating in the deep dermis, subcutaneous tissue, fascia, and muscles, are common in DM but only occasionally described in SSc [42][43][44]. Pseudoxanthoma elasticum-like calcification [45] and dystrophic calcinosis secondary to localized linear scleroderma have also been reported [46].…”

Section: Calcinosis Cutis and Systemic Sclerosismentioning

confidence: 99%

Calcinosis Cutis and Calciphylaxis in Autoimmune Connective Tissue Diseases

et al. 2023

View full text Add to dashboard Cite

Calcinosis represents a severe complication of several autoimmune disorders. Soft-tissue calcifications have been classified into five major types: dystrophic, metastatic, idiopathic, iatrogenic, and calciphylaxis. Autoimmune diseases are usually associated with dystrophic calcifications, including calcinosis cutis, occurring in damaged or devitalized tissues in the presence of normal serum levels of calcium and phosphate. In particular, calcinosis cutis has been described in dermatomyositis, polymyositis, juvenile dermatomyositis, systemic sclerosis, systemic lupus erythematosus, primary Sjögren’s syndrome, overlap syndrome, mixed connective tissue disease, and rheumatoid arthritis. Calciphylaxis, a severe and life-threatening syndrome presenting with vascular calcifications and thrombosis, has also been associated with some autoimmune conditions. Due to the potentially disabling character of calcinosis cutis and calciphylaxis, physicians’ awareness about the clinical presentation and management of these diseases should be increased to select the most appropriate treatment option and avoid long-term complications. In this review, we aim to analyze the clinical features of calcinosis cutis and calciphylaxis associated with autoimmune diseases, and the main treatment strategies evaluated up to now for treating this potentially disabling disease.

show abstract