Calcinosis cutis

Reiter, Nadine; El-Shabrawi, Laila; Leinweber, Bernd; Berghold, Andrea; Aberer, Elisabeth

doi:10.1016/j.jaad.2010.08.038

Cited by 251 publications

(193 citation statements)

References 82 publications

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“…25 Histologically, calciphylaxis is characterized by calcification, microthrombosis, and fibrointimal hyperplasia of small dermal and subcutaneous arteries and arterioles leading to ischemia and intense septal panniculitis (Figure 2). 26-28 Calcification most commonly involves the medial layer of small arteries and arterioles; however, involvement of the intimal layer and the interstitium of subcutaneous adipose tissue has been reported. 17 Calcification is considered to be an early and essential process in calciphylaxis plaque development and it is hypothesized that the vascular calcification leads to vascular endothelial dysfunction and injury.…”

Section: Introductionmentioning

confidence: 99%

Calciphylaxis: Risk Factors, Diagnosis, and Treatment

Nigwekar

Kroshinsky

Nazarian

et al. 2015

American Journal of Kidney Diseases

356

505

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Calciphylaxis is a rare but devastating condition that has continued to challenge the medical community since its early descriptions in the scientific literature many decades ago. It is predominantly seen in chronic kidney failure patients treated with dialysis (uremic calciphylaxis) but is also described in patients with earlier stages of chronic kidney disease and with normal renal function. In this In Practice feature, we review the available medical literature regarding risk factors, diagnosis, and treatment of both uremic and non-uremic calciphylaxis. High quality evidence for the evaluation and management of calciphylaxis is lacking at this time due to its rare incidence, poorly understood pathogenesis, and the relative paucity of collaborative research efforts. We hereby provide a summary of recommendations developed by the Massachusetts General Hospital's Multi-disciplinary Calciphylaxis Team for calciphylaxis patients.

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Section: Introductionmentioning

confidence: 99%

Calciphylaxis: Risk Factors, Diagnosis, and Treatment

Nigwekar

Kroshinsky

Nazarian

et al. 2015

American Journal of Kidney Diseases

356

505

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“…15 Proximal involvement of calciphylaxis, as in our case, has been associated with a poorer prognosis. 3 We believe that our patient's remarkable recovery is due to intense wound care and to the prompt initiation of treatment with a bisphosphonate and sodium thiosulfate, even in the context of a normal calciumphosphate axis. The impressive and sustained clinical improvement was also attributed to lenalidomide, which treated the underlying plasma cell dyscrasia.…”

Section: Discussionmentioning

confidence: 86%

“…It has been traditionally described in patients with end-stage renal disease but can also be observed in nonuremic patients. 2,3 Four cases of POEMS syndrome associated with calciphylaxis have been reported. [4][5][6][7] We present a fifth case of POEMS syndrome and calciphylaxis.…”

mentioning

confidence: 99%

POEMS Syndrome Complicated by Extensive Calciphylaxis: A Remarkable Recovery

Bourgeault¹,

Dahl²,

Thibeault³

et al. 2015

J Cutan Med Surg

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“…It has been observed in burn scars, surgical scars, connective tissue diseases, inherited disorders, infections and trauma [12,13]. Incidental histological findings of microcalcification have also been detected in cutaneous neoplasms such as trichoepithelioma, basal cell carcinoma, pilomatricoma, fibroma and nevus.…”

Section: Discussionmentioning

confidence: 99%

“…It occurs in areas of cell necrosis in which phosphate-bound denatured proteins are subject to ectopic calcification, promoted by alterations in collagen, elastin and subcutaneous fat [12]. Tissue alterations observed in TEN patients can act like a nidus for dystrophic ectopic calcification.…”

Section: Discussionmentioning

confidence: 99%

Facial Scars following Toxic Epidermal Necrolysis: Role of Adnexal Involvement?

Habre

Ortonne²,

Colin³

et al. 2016

Dermatology

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Toxic epidermal necrolysis (TEN) is a severe cutaneous adverse drug reaction leading to extensive sloughing of the skin. Late cutaneous complications such as pigmentation disorders are frequently reported. In this report, we present particular facial cutaneous sequelae with histological analysis after TEN. Two young patients who had survived TEN presented permanent multiple hypopigmented papules on the face affecting their quality of life. Histological analysis revealed areas of scarring, dystrophic microcalcifications and sebaceous hyperplasia. Late cutaneous sequelae are well documented; however, the physiopathological mechanisms leading to different clinical presentations remain unknown. We suggest that the destruction of the hair follicle by necrolysis leads to secondary dermal microcalcifications, scarring and sebaceous hyperplasia. Further studies are needed for a better understanding of these findings.

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Calcinosis cutis

Cited by 251 publications

References 82 publications

Calciphylaxis: Risk Factors, Diagnosis, and Treatment

Calciphylaxis: Risk Factors, Diagnosis, and Treatment

POEMS Syndrome Complicated by Extensive Calciphylaxis: A Remarkable Recovery

Facial Scars following Toxic Epidermal Necrolysis: Role of Adnexal Involvement?

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