Calcineurin Inhibitor-Based Immunosuppressive Therapy, Donor Age, and Long-Term Outcome After Kidney Transplantation

Heinze, Georg; Oberbauer, Rainer; Kainz, Alexander; Mitterbauer, Cllrista; Koppelstaetter, Christian; Hörl, Walter H.; Mayer, Gert

doi:10.1097/tp.0b013e3181a66cfc

Cited by 8 publications

(2 citation statements)

References 29 publications

(22 reference statements)

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“…A recent study from Vienna looked at 1823 first kidney transplants from 1990 to 2003. They found significantly better patient survival for patients who received Calcineurin inhibitor containing maintenance immunosuppression when compared to those without it (0.41, 95% CI 0.30–0.57) [20]. …”

Section: Discussionmentioning

confidence: 99%

Death with functioning kidney transplant: an obituarial analysis

2010

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BackgroundDeath with a functioning kidney graft (DWFG) is now a major cause of graft loss after renal transplantation, occurring in up to 40% of cases. Its occurrence provides insight into the medical care of subjects with a functioning kidney transplant. In this study, we used the time to DWFG as an endpoint, to test whether improved medical care has contributed to better kidney transplant outcomes.MethodsWe used single-center data from the Milwaukee Regional Medical Center and Froedtert Hospital, on kidney-only transplants from 1969 through 2005. A total of 3,157 kidney transplants were done at our center during this time. There were 714 deaths with functioning kidney. We also recorded the major causes of DWFG over the time period from 1969 through 2005 divided into 3 epochs. The data were analyzed as a serial collection of yearly obituaries.ResultsThe time to DWFG has increased to 10 years despite a 20-year increase in the mean age of transplant recipients over the same time period.ConclusionsBetter pre-transplant evaluation, improved treatments for hypertension and hyperlipidemia, improved management of acute myocardial infarction, superior immunosuppressive protocols and better prophylaxis and treatment of infectious diseases have all likely contributed to this trend.

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Section: Discussionmentioning

confidence: 99%

Death with functioning kidney transplant: an obituarial analysis

2010

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“…Immunosuppressive therapy after allograft solid organ transplantation is required to prevent rejection and preserve organ function (40)(41)(42)(43). Various combinations of currently approved agents are needed to obtain the patients' tailored regimens to balance adequate immunosuppression with drugs' side effects (44)(45)(46)(47) through continuous titration to reduce their side effects due to their narrow therapeutic index (48)(49)(50)(51).…”

Section: Drugsmentioning

confidence: 99%

Implementation of Blockchain Technology Could Increase Equity and Transparency in Organ Transplantation: A Narrative Review of an Emergent Tool

Anselmo¹,

Materazzo²,

Lorenzo³

et al. 2023

Transpl Int

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In the last few years, innovative technology and health care digitalization played a major role in all medical fields and a great effort worldwide to manage this large amount of data, in terms of security and digital privacy has been made by different national health systems. Blockchain technology, a peer-to-peer distributed database without centralized authority, initially applied to Bitcoin protocol, soon gained popularity, thanks to its distributed immutable nature in several non-medical fields. Therefore, the aim of the present review (PROSPERO N° CRD42022316661) is to establish a putative future role of blockchain and distribution ledger technology (DLT) in the organ transplantation field and its role to overcome inequalities. Preoperative assessment of the deceased donor, supranational crossover programs with the international waitlist databases, and reduction of black-market donations and counterfeit drugs are some of the possible applications of DLT, thanks to its distributed, efficient, secure, trackable, and immutable nature to reduce inequalities and discrimination.

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Effect of cyclosporine, tacrolimus and sirolimus on cellular senescence in renal epithelial cells

Koppelstaetter

Kern

Leierer

et al. 2018

Toxicology in Vitro

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Calcineurin Inhibitor-Based Immunosuppressive Therapy, Donor Age, and Long-Term Outcome After Kidney Transplantation

Abstract: Use of CNI 90 days after transplantation is associated with improved patient survival even after adjustment for confounders, but its beneficial association with actual and functional graft survival is lost or at least reduced if kidneys from donors older than 50 years are used.

Cited by 8 publications

References 29 publications

Death with functioning kidney transplant: an obituarial analysis

Death with functioning kidney transplant: an obituarial analysis

Implementation of Blockchain Technology Could Increase Equity and Transparency in Organ Transplantation: A Narrative Review of an Emergent Tool

Effect of cyclosporine, tacrolimus and sirolimus on cellular senescence in renal epithelial cells

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