Calcifying Pseudoneoplasm of the Neuraxis: From Pathogenesis to Diagnostic and Therapeutic Considerations

Yang, Kaiyun; Reddy, Kesava; Chebib, Ivan; Hammond, Robert; Lu, Jian‐Qiang

doi:10.1016/j.wneu.2021.01.076

Cited by 18 publications

(32 citation statements)

References 44 publications

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“…In the second case, the tumor was extra-axial along the right tentorial leaf presenting with headaches and vestibular symptoms. The neuroradiological features of intracranial CAPNONs are consistent with a calcified mass resembling a fibro-osseous lesion [1] . Specifically, on CT CAPNONs appear as outlined solid lesions that are peripherally calcified, whereas on MRI they show some extent of hypointensity in both T1- and T2- sequences, with absent or minimal peripheral gadolinium enhancement, and are not associated to surrounding vasogenic edema [ 24 ].…”

Section: Discussionmentioning

confidence: 74%

“…CAPNONs are rare lesions of the CNS affecting both children and adults with a modest male predominance [1] . They are slow-growing benign lesions presumably attributable to a reactive proliferative process induced by various trigger factors, such as infection, inflammation and injury, and may be possibly associated with inflammatory, degenerative, vascular and neoplastic diseases [2] , [3] , [4] .…”

Section: Discussionmentioning

confidence: 99%

“…These are also known as fibro-osseous lesion of the CNS and are slow-growing, solitary lesions, most frequently seen in the supratentorial compartment. These are more frequently extra-axial but can be intra-axial as well with characteristic histopathological finings [ 1 , 2 ]. As this is a relatively newly described entity, it is presumed that many of these conditions were historically misdiagnosed.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Calcifying pseudoneoplasms of the neuraxis (CAPNON): The great tumor mimicker

Greco

Elmandouh²,

Desai³

et al. 2022

Radiology Case Reports

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Section: Discussionmentioning

confidence: 74%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Calcifying pseudoneoplasms of the neuraxis (CAPNON): The great tumor mimicker

Greco

Elmandouh²,

Desai³

et al. 2022

Radiology Case Reports

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“…Although vasogenic edema is an uncommon radiographic feature, there are four reported cases of vasogenic edema at the time of disease progression and in more symptomatic patients. 3,[11][12][13] On histopathological analysis, CAPNONs are typically well-circumscribed masses with variable morphologic features including a chondroid matrix with fibrillary to amorphous architecture, fibrous stroma, peripheral "ropey" cords, and a ring of palisading spindled to epithelioid to multinucleated giant cells. They may also display multifocal calcifications, metaplastic mature bone, metaplastic mature adipose, or psammoma bodies.…”

Section: Discussionmentioning

confidence: 99%

Calcifying Pseudoneoplasm of the Neuraxis Presenting with Vasogenic Edema and a Perilesional Cyst

et al. 2022

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Calcifying pseudoneoplasms of the neuraxis (CAPNONs) are uncommon benign lesions that are rarely diagnosed radiographically. We report an unusual case of a left middle cerebellar peduncle CAPNON with vasogenic edema and a perilesional cyst. The patient was a 36-year-old woman with a 20-year history of left-sided hearing loss that had recently progressed. Computed tomography and magnetic resonance imaging showed a heterogenous calcified lesion with vasogenic edema and a perilesional cyst in the left middle cerebellar peduncle. Although it is a rare radiographic feature of CAPNON, vasogenic edema should be included as a possible feature of this uncommon tumefactive lesion.

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“…CAPNON is a rare fibro-osseous lesion that can develop anywhere in the neuroaxis, with a challenging diagnosis. Most cases have been diagnosed after surgical resection, and there have been reports exposing them as collision lesions, especially with lipoma [ 8 ].…”

Section: Discussionmentioning

confidence: 99%

Macro Pituitary Adenoma and Frontal Calcified Cavernous Malformation: A Coincidence or a True Partnership?

Suck¹,

Balcázar-Padrón²,

Llano³

et al. 2022

Cureus

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Collision tumors are rare neoplasms composed of two different types of histological tissues in the same organ. The most frequent association with cerebral cavernous malformations (CCMs) are meningiomas, gliomas, and gangliogliomas, while the most frequent sellar collision is between pituitary adenoma (PA) and craniopharyngiomas, and still very few cases have been reported. We present the case of a 43-year-old woman who started two months ago with a fall from her height followed by severe headache and bilateral hemianopsia. An isointense, enhancing sellar tumor, and a right frontal lesion compatible with CCM were observed on MRI. Surgery was performed through anterior interhemispheric and endoscopic transnasal approaches for the cavernoma and the sellar tumor, respectively, removing both lesions and sending them to pathology. The sellar tumor corresponded to a PA showing positive immunohistochemistry for prolactin and follicle-stimulating hormone (FSH). In the post-op period, the patient developed a seizure and diabetes insipidus, for which she received appropriate treatment. Our findings were conclusive with a collision tumor, since both lesions presented two different histological tissues. Different densities were observed in both lesions using imaging studies, which were later confirmed with histopathology and immunohistochemistry.

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Calcifying Pseudoneoplasm of the Neuraxis: From Pathogenesis to Diagnostic and Therapeutic Considerations

Cited by 18 publications

References 44 publications

Calcifying pseudoneoplasms of the neuraxis (CAPNON): The great tumor mimicker

Calcifying pseudoneoplasms of the neuraxis (CAPNON): The great tumor mimicker

Calcifying Pseudoneoplasm of the Neuraxis Presenting with Vasogenic Edema and a Perilesional Cyst

Macro Pituitary Adenoma and Frontal Calcified Cavernous Malformation: A Coincidence or a True Partnership?

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