Calcifying pseudoneoplasm (fibro osseous lesion) of neuraxis (CAPNON) – a case report

Mohapatra, Ishani; Manish, R Pandya; Mahadevan, Anita; Prasad, Csbr; Somanna, Sampath; Shankar, S K

doi:10.5414/npp29223

Cited by 25 publications

(21 citation statements)

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“…The frequent adjacent granulomatous and inflammatory reaction along with an indolent course and a generally good prognosis support a benign or reactive rather than neoplastic process . Of the 65 cases of CAPNON that we identified in the literature, only one case presented with two separate lesions diagnosed 8 years apart in the same individual . The remaining 64 cases were solitary.…”

Section: Introductionmentioning

confidence: 77%

Multiple calcifying pseudoneoplasms of the neuraxis (MCAPNON): Distinct entity, CAPNON variant, or old neurocysticercosis?

Abdaljaleel

Mazumder

et al. 2016

Neuropathology

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We report a case of multiple calcifying pseudoneoplasms of the neuraxis (MCAPNON) with associated multifocal perivascular microcalcifications and vascular calcinosis. Calcifying pseudoneoplasm of the neuraxis (CAPNON) is a very rare condition that may arise in extra-axial and occasionally, in intra-axial locations. Moreover, it is nearly always a solitary mass with only one case with two lesions reported. While the etiology and pathogenesis of CAPNON remains unclear, the histopathology findings of this entity have been well described. We report a case of a 62-year-old woman with 18 calcifying radiologic lesions involving bilateral cerebral hemispheres. Histologically, these lesions have features similar to that reported for CAPNON, including nodular calcification with fibro-osseous components and peripheral histiocytic reaction. The patient had a poorly documented diagnosis of neurocyticercosis 32 years prior, although without tissue confirmation. The lack of detectable cysticercus serum antibody titers, and absence of residual larval or cyst wall tissue render multifocal calcific involution of that parasite unprovable although still plausible. We also raise the possibility of a blood-brain barrier derangement and/or a metabolic disorder as an alternative etiology. Whether this case of MCAPNON shares the same pathogenesis as the usual solitary CAPNON is unclear.

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Section: Introductionmentioning

confidence: 77%

Multiple calcifying pseudoneoplasms of the neuraxis (MCAPNON): Distinct entity, CAPNON variant, or old neurocysticercosis?

Abdaljaleel

Mazumder

et al. 2016

Neuropathology

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“…Calcified, fibro-osseous lesions known as calcifying pseudoneoplasms of the neuraxis, cerebral calculi, or brain stones are extremely rare and are usually seen at the cranial base, commonly adjacent to the dura mater or the arachnoid 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29. However, they can occur anywhere within the neuraxis 2,3,5.…”

Section: Discussionmentioning

confidence: 99%

“…The patients with intracranial type most commonly presented with seizure (31.6%) followed by headache (13.2%) and cerebellar sign (5.3%) 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23. Three patients (8.1%) were found incidentally, and seven cases (18.9%) were autopsy findings.…”

Section: Discussionmentioning

confidence: 99%

Calcifying Pseudoneoplasms of the Skull Base Presenting with Cranial Neuropathies: Case Report and Literature Review

et al. 2012

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Objectives We report our institutional experience with calcifying pseudoneoplasms of the skull base that presented with cranial neuropathies. These lesions are also known as fibro-osseous lesions, cerebral calculi, or brain stones.Results One patient presented with facial numbness and retro-orbital pain secondary to compression of the maxillary branch of the trigeminal nerve at the anterior portion of the infratemporal fossa. The other patient presented with occipital headaches and hypoglossal nerve palsy. This patient was found to have a calcified lesion in the posterior fossa, which eroded the left occipital condyle.Conclusion Calcifying pseudoneoplasms are benign, slow-growing masses that are apparently cured by gross total resection. Even with incomplete tumor resection, the prognosis is considered to be favorable. We advocate a minimally invasive surgical resection of such tumors involving the cranial nerves.

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“…CAPNONs have been mentioned in the literature since 1922 as unusual fibro-osseous lesions of the brain (1,6). They were recognized as a distinct entity in 1978 and there are 40 international reported cases (1,7,9). Most of the published articles mention no sex or age predominance with an age range of 6-83 years (1,3).…”

Section: Discussionmentioning

confidence: 99%

“…The classic histopathological features of CAPNON include a set of common elements: 1) presence of chondromyxoid matrix in a nodular pattern; 2) palisading spindle to epithelioid cells; 3) fibroblastic proliferation; 4) amorphous calcification, psammoma bodies and osseous metaplasia; 5) foreign-body reaction with giant cells surrounding the calcified region (1,3,7). These pathological presentations are not evident in each case and some lesions may not show all of the above features (3).…”

Section: Discussionmentioning

confidence: 99%

A case report of calcifying pseudoneoplasm of the neuraxis: an incidental finding after a car accident

Zerehpoosh¹,

Samadian²,

Azhari³

et al. 2016

TJPATH

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Calcifying pseudoneoplasms of the neuraxis are rare, poorly understood lesions that can occur anywhere in the central nervous system without any age or sex predilection. Their pathogenesis is still controversial. Patients can present with various symptoms due to lesion location and only few cases have been discovered incidentally. We present a 25-year-old male referred to our hospital after a car accident. Computed tomography scan and magnetic resonance imaging was done because of the patient's head trauma and a calcified intracranial lesion was found and excised surgically. Pathologic evaluation of the specimen was consistent with the diagnosis of calcifying pseudoneoplasm of the neuraxis.

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Calcifying pseudoneoplasm (fibro osseous lesion) of neuraxis (CAPNON) – a case report

Cited by 25 publications

References 0 publications

Multiple calcifying pseudoneoplasms of the neuraxis (MCAPNON): Distinct entity, CAPNON variant, or old neurocysticercosis?

Multiple calcifying pseudoneoplasms of the neuraxis (MCAPNON): Distinct entity, CAPNON variant, or old neurocysticercosis?

Calcifying Pseudoneoplasms of the Skull Base Presenting with Cranial Neuropathies: Case Report and Literature Review

A case report of calcifying pseudoneoplasm of the neuraxis: an incidental finding after a car accident

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