Calcifying odontogenic cyst

Ebling, Hardy; Wagner, João Ephraim

doi:10.1016/0030-4220(67)90434-3

Cited by 14 publications

(2 citation statements)

References 3 publications

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“…These ‘transitory’ cells would accumulate another unknown intracytoplasmic substance during the differentiation process, and gradually repel the cytoskeletal system to the periphery, until becoming well developed K10/13‐negative ghost cells. Furthermore, several early studies using electronic microscopy, histochemistry and immunohistochemistry suggested normal or abnormal keratinization processes occurring in the ghost cells and CCOT epithelial cells (10–18). Those opinions were also pondered by Regezi et al.…”

Section: Discussionmentioning

confidence: 99%

Immunoexpression of keratins in the calcifying cystic odontogenic tumor epithelium

Crivelini¹,

Felipini²,

Coclete³

et al. 2009

J Oral Pathology Medicine

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Ameloblastomatous epithelium containing clusters of ghost cells is the typical histopathology of calcifying cystic odontogenic tumor (CCOT). This paper aimed to assess keratins AE1-AE3, K7, K10/13, K14, K18, K19, vimentin, laminin, and collagen IV in 08 CCOTs to discuss their histopathogenesis. Similarity to the immunoprofile of the stratified squamous epithelium was seen in the with the basal layer expressing K14 and the upper cells expressing K10/13. When compared to the immunoprofile of the normal odontogenic epithelium, of odontogenic tumor epithelia and of the ghost cells described in the literature, it was possible to suggest that the CCOT epithelium differentiates towards squamous type.

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Section: Discussionmentioning

confidence: 99%

Immunoexpression of keratins in the calcifying cystic odontogenic tumor epithelium

Crivelini¹,

Felipini²,

Coclete³

et al. 2009

J Oral Pathology Medicine

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“…14 Ghost cells are swollen and keratinized cells without nuclei, with a clear conservation of basic cellular outlines, endowed with resistance to resorption and tendency to develop foreign body granulomas. 15 However, the nature of the ghost cells is not clear and many hypotheses have been advanced and are under debate. Some of the hypotheses are (1) Ghost cells have been considered as abnormal keratinized bodies, 16 (2) they may represent simple cell degeneration or a form of enamel matrix, 17 (3) ghost cells might derive from the apoptotic process of odontogenic cells or represent different stages of normal and abnormal keratin formation, therefore, deriving from metaplastic transformation of odontogenic tumors.…”

Section: Jcdpmentioning

confidence: 99%

Histopathologic Diversity of Gorlin's Cyst: A Study of Four Cases and Review of Literature

Sonawane¹,

Singaraju²,

Gupta³

et al. 2011

The Journal of Contemporary Dental Practice

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Aim The purpose of the present article is to discuss four different case reports of the so-called calcifying odontogenic cyst and highlight the histopathological diversity of the same. Background Calcifying odontogenic cyst was first described by Gorlin et al in 1962. Ever since, its identification as a specific odontogenic lesion, controversies and confusions have existed regarding the relationship between cystic lesions and solid tumor masses that share cellular and histomorphologic features. Although several classifications were proposed, dilemma still persists regarding the nature of these lesions as cysts, neoplasms and even malignancies. Conclusion and clinical significance The classifications discussed for the so-called calcifying odontogenic cyst by various authors have only added to further confusion rather than enlightening. Though many authors state that classifications remain only an academic exercise, it definitely has significance in treatment planning. Emphasis should, therefore, be laid on a universally accepted classification. How to cite this article Sonawane K, Singaraju M, Gupta I, Singaraju S. Histopathologic Diversity of Gorlin's Cyst: A Study of Four Cases and Review of Literature. J Contemp Dent Pract 2011;12(5):392-397.

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