Calcifying Fibrous Tumor of the Gastric Wall

祥貴, 北村; 朗, 竹原; 雅也, 島田; 秀樹, 森山; 健一郎, 斉藤; 匡宏, 羽田; 一繁, 芝原; 正寿, 佐々木; 孝司, 小西; 宜延, 前田

doi:10.5833/jjgs.42.1773

Cited by 7 publications

(1 citation statement)

References 12 publications

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“…On the other hand, immunostaining for CD117, c-Kit, desmin, actin, S100, smooth muscle actin and anaplastic lymphoma kinase is negative, which distinguishes CFT from GIST, schwannoma, leiomyoma, inflammatory myofibroblastic tumour (IMT) and other gastric tumours. 4 , 5 …”

Section: Discussionmentioning

confidence: 99%

Imaging findings of gastric calcifying fibrous tumour

et al. 2016

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Calcifying fibrous tumours (CFTs) are rare benign lesions that usually affect the soft tissues, the mesentery and the peritoneum. Gastric CFT is particularly rare. Here, we report a CFT found incidentally in a 31-year-old male. The mass was well circumscribed and showed partial calcification on the CT scan, with dark signal intensity seen on T2 weighted MRI. To the best of our knowledge, there is very limited published information concerning imaging findings of CFTs. We discuss the CT scan and MRI findings of this patient, which can be considered typical for gastric CFT, and present a review of the limited literature available.

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Section: Discussionmentioning

confidence: 99%

Imaging findings of gastric calcifying fibrous tumour

et al. 2016

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Gastric calcifying fibrous tumor: A clinicopathological study of nine cases

et al. 2018

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The aim of the present study was to analyze the clinicopathological characteristics presented in 9 cases of gastric calcifying fibrous tumor (CFT), and investigate the expressions and clinical implications of G protein-coupled estrogen receptor (GPER), estrogen receptor (ER) and vimentin in gastric CFTs. The clinical and pathological information of 9 patients with CFTs was investigated retrospectively. Subsequently, the expression of GPER, ER and vimentin were examined using immunohistochemistry, and a literature search for gastric CFT was conducted. The 9 patients were 40–71 years old with a mean age of 52.22 years, including 6 female and 3 male patients. Pathological features included dense hyalinized collagen fibers with a psammomatous body or dystrophic calcification, and the infiltration of scattered lymphocytes and plasma cells. Immunohistochemically, all cases expressed vimentin and GPER, whereas ER expression was negative. Using a database research, 25 studies regarding gastric CFT were identified, including 48 cases with a sex ratio (female:male) of 1.4:1. In addition, the number of female patients was twice the number of male patients in patients <50 years old, whereas the number was almost equal between women and men ≥50 years of age. Gastric CFT is a benign lesion with a good prognosis and a predilection for female patients, particularly premenopausal women. Estrogen may serve a role in this female predominance, and this may be mediated by GPER rather than ER.

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