Calcification of the mitral annulus

Fulkerson, Phillip K.; Beaver, Brian M.; Auseon, John C.; Graber, Harry L.

doi:10.1016/0002-9343(79)90452-2

Cited by 246 publications

(25 citation statements)

References 60 publications

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“…The right sided heart valves were involved in nine cases only in the present hemodialysis population, which is consistent with previous published data [11, 12, 27, 28]. It has been reported that the mitral valve is most commonly involved in left-sided IE in hemodialysis patients [11, 12, 27, 28], which may be due to annular calcification of the mitral valve [42]. In accordance with this observation we found mitral valve endocarditis in 51.2% of the hemodialysis patients.…”

Section: Discussionsupporting

confidence: 91%

The impact of hemodialysis on mortality risk and cause of death in Staphylococcus aureus endocarditis

et al. 2018

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BackgroundThe risk of infective endocarditis (IE) is markedly increased in patients receiving chronic hemodialysis compared with the general population, but outcome data are sparse. The present study investigated causes and risk factors of mortality in a hemodialysis-treated end-stage kidney disease- (ESKD) and a non-ESKD population with staphylococcus (S.) aureus endocarditis.MethodsHemodialysis-treated ESKD patients with S. aureus endocarditis were identified from Danish National Registries and Non-ESKD patients from The East Danish Database on Endocarditis. For establishing the cause of death The Danish Registry of Cause of Death was used. Independent risk factors of outcome were identified in multivariable Cox regression models.ResultsOne hundred twenty-one hemodialysis patients and 190 non-ESKD patients with S. aureus endocarditis were included during 1996–2012 and 2002–2012, respectively. The all-cause in-hospital mortality was 22.3% in hemodialysis- and 24.7% in non-ESKD patients. One-year mortality, excluding in-hospital mortality, was 26.4% in hemodialysis patients and 15.2% in non-ESKD patients.The hazard ratio of all-cause mortality in hemodialysis was 2.64 (95% CI 1.70–4.10) at > 70 days after admission compared with non-ESKD. Age (HR 1.03 (95% CI 1.02–1.04)) and diabetes mellitus (HR 2.17 (95% CI 1.54–3.10)) were independent risk factors of all-cause mortality. The hazard ratio of cardiovascular death in hemodialysis was 3.20 (95% CI 1.78–5.77) at > 81 days after admission compared with non-ESKD. Age and diabetes mellitus were independently related to cardiovascular death.ConclusionAll-cause in-hospital mortality rates were similar in hemodialysis and non-ESKD patients with S. aureus endocarditis whereas one-year mortality rates were significantly increased in the hemodialysis population.Electronic supplementary materialThe online version of this article (10.1186/s12882-018-1016-0) contains supplementary material, which is available to authorized users.

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Section: Discussionsupporting

confidence: 91%

The impact of hemodialysis on mortality risk and cause of death in Staphylococcus aureus endocarditis

et al. 2018

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“…Conditions that increase left ventricular systolic pressure, such as hypertension and aortic stenosis, are associated with MAC and may accelerate the degenerative process [26]. MAC has been identified in up to 53% of women and 35% of men who reside in a nursing home [27].…”

Section: Mitral Annular Calcificationmentioning

confidence: 99%

Valvular Heart Disease in Aging Women

Petersen

Limacher

2011

Curr Cardiovasc Risk Rep

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Elderly women are at risk for aortic and mitral valve disease that may be challenging to manage because of co-morbidities. Many reports focus on the evaluation and management of elderly patients, but only limited information that is directed specifically at women is available. Until more research can be completed, current guidelines offer updated recommendations for the diagnosis and treatment of significant valvular lesions. On-line and point-based risk assessment instruments are valuable tools for guiding treatment decisions in individual patients.

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“…The association between MAC and atrial fibrillation, cerebral embolization, acquired mitral stenosis, hypertension, hyperlipidemia, diabetes, coronary artery disease, aortic atheroma, and diffuse atherosclerosis has been well documented. According to several clinical and clinicopathologic studies [2-9], the risk of cerebrovascular events (CVE) in patients with MAC ranges from 4.8% to 24.1% (Table 1 ).…”

Section: Introductionmentioning

confidence: 99%

Risk of Cerebral Embolization with Caseous Calcification of the Mitral Annulus: Review Article

Dietl

Hawthorn

Raizada

2016

TOCMJ

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Background:Caseous calcification of the mitral annulus (CCMA) is believed to have a benign prognosis. Several authors have recommended conservative management in asymptomatic patients. However, the prevalence of cerebrovascular events (CVE) in patients with CCMA has never been evaluated before. The aims of this study are to investigate whether patients with CCMA are at increased risk of cerebral embolization, and to determine whether elective surgical resection of CCMA should be considered to prevent a cardioembolic stroke.Methods:A comprehensive literature search was obtained from MEDLINE via PubMed.gov, ScienceDirect.com, and Google Scholar using the following search queries: caseous calcification of the mitral annulus, intracardiac pseudotumor, mitral annular calcification, and cardioembolic stroke.Results:From our initial search that yielded 1,502 articles, we identified a total of 130 patients with CCMA reported in 86 publications. Literature review revealed that the prevalence of CVE associated with CCMA is 19.2% (25 of 130) which is significantly higher than the prevalence of CVE reported with mitral annular calcification (MAC), 11.8% (214 of 1818) (range 4.8% to 24.1%) (P = 0.01796) (odds ratio = 1.78; 0.95 confidence interval = 1.1278 – 2.8239). Only four of 25 (16.0%) patients with CCMA who suffered a CVE had history of atrial fibrillation (AF).Conclusion: Based on our review, it would be reasonable to consider elective surgical resection of CCMA in asymptomatic patients who are good surgical candidates, because patients with CCMA may be at increased risk of embolic strokes, which are unrelated to AF.

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Calcification of the mitral annulus

Cited by 246 publications

References 60 publications

The impact of hemodialysis on mortality risk and cause of death in Staphylococcus aureus endocarditis

The impact of hemodialysis on mortality risk and cause of death in Staphylococcus aureus endocarditis

Valvular Heart Disease in Aging Women

Risk of Cerebral Embolization with Caseous Calcification of the Mitral Annulus: Review Article

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