Calcification of abdominal aorta in patients recently starting hemodialysis: A single-center experience from Egypt

Nokeety, Mahmoud M El; Attia, Khaled; Din, Usama A Sharaf El

doi:10.4103/1319-2442.265457

Cited by 5 publications

(2 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…selected 81 patients with non-diabetic end-stage renal disease (ESRD) who initiated HD, discovering that abdominal aortic calci cation was present in 64 patients (79%). A signi cant correlation was observed between the abdominal aortic calci cation score and both age and FGF23, with serum FGF23 levels being the sole statistically signi cant factor associated with abdominal aortic calci cation in these patients [14] . Muzasti RA et al found that patients with HD who had abdominal aortic calci cation…”

Section: Discussionmentioning

confidence: 83%

The Role of Fibroblast Growth Factor 23 in Vascular Calcification in Peritoneal Dialysis Patients

Xie,

Si,

Wang

et al. 2024

Preprint

View full text Add to dashboard Cite

Background This research investigates the correlation between serum fibroblast growth factor 23 (FGF23) levels and vascular calcification in individuals undergoing peritoneal dialysis (PD). Methods The study period spanned from January 2021 to August 2023, 220 patients receiving peritoneal dialysis at our hospital were selected as participants. FGF23 concentrations were determined through an enzyme-linked immunosorbent assay (ELISA), and coronary multi-slice spiral computed tomography (CT) and upright abdominal X-ray examinations were conducted to evaluate calcification scores. The relationship between FGF23 levels and vascular calcification in PD patients was analyzed. Results FGF23 levels were significantly positively correlated with coronary artery calcification (CAC), abdominal aortic calcification (AAC), brachial-ankle pulse wave velocity (baPWV), and high-sensitivity C-reactive protein (CRP). When patients were stratified by coronary calcification scores, there was statistical difference in FGF23 levels between the mild-to-moderate calcification group and the non-calcification group, significant differences were observed between the mild-to-moderate calcification group and the severe calcification group, as well as between the non-calcification group and the severe calcification group. Similarly, significant differences in FGF23 levels were observed among groups stratified by abdominal aortic calcification scores, with FGF23 levels significantly increasing with the severity of calcification. The diagnostic efficacy of FGF23 levels in detecting coronary artery calcification was assessed using a receiver operating characteristic (ROC) curve analysis, yielding a sensitivity of 61.35% and a specificity of 73.68%. Similarly, for abdominal aortic calcification, the ROC curve analysis revealed a sensitivity of 58.9% and a specificity of 69.57%. Conclusion The study concludes that serum FGF23 levels are linked to coronary artery calcification in PD patients and can be utilized as a supplementary indicator for diagnosing this condition.

show abstract

Section: Discussionmentioning

confidence: 83%

The Role of Fibroblast Growth Factor 23 in Vascular Calcification in Peritoneal Dialysis Patients

Xie,

Si,

Wang

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

“…Therefore, researchers have suggested that the CAC score is a valid indicator for favorable long-term risk prediction and the risk stratification of patients with CKD[ 4 , 88 , 89 ]. Numerous findings have recently suggested that abdominal aortic calcification (AAC) is an independent predictor of all-cause mortality in patients undergoing dialysis, particularly those undergoing peritoneal dialysis [ 90 - 92 ]. Moreover, the AAC score may be used to assess targeted risk-lowering strategies for kidney transplant recipients [ 93 ].…”

Section: Vc Is a Severe Detrimental Cardiovascular Complication Of Ckdmentioning

confidence: 99%

Vascular Calcification in Chronic Kidney Disease: An Update and Perspective

Ren

et al. 2022

Aging and disease

View full text Add to dashboard Cite

Chronic kidney disease is a devastating condition resulting from irreversible loss of nephron numbers and function and leading to end-stage renal disease and mineral disorders. Vascular calcification, an ectopic deposition of calcium-phosphate salts in blood vessel walls and heart valves, is an independent risk factor of cardiovascular morbidity and mortality in chronic kidney disease. Moreover, aging and related metabolic disorders are essential risk factors for chronic kidney disease and vascular calcification. Marked progress has been recently made in understanding and treating vascular calcification in chronic kidney disease. However, there is a paucity of systematic reviews summarizing this progress, and investigating unresolved issues is warranted. In this systematic review, we aimed to overview the underlying mechanisms of vascular calcification in chronic kidney diseases and discuss the impact of chronic kidney disease on the pathophysiology of vascular calcification. Additionally, we summarized potential clinical diagnostic biomarkers and therapeutic applications for vascular calcification with chronic kidney disease. This review may offer new insights into the pathogenesis, diagnosis, and therapeutic intervention of vascular calcification.

show abstract

Role of klotho and fibroblast growth factor 23 in arterial calcification, thickness, and stiffness: a meta-analysis of observational studies

Wungu,

Susilo,

Alsagaff

et al. 2024

Sci Rep

View full text Add to dashboard Cite

This meta-analysis was conducted to clarify the role of klotho and fibroblast growth factor 23 (FGF-23) in human arterial remodeling across recent studies, in terms of arterial calcification, thickness, and stiffness. A systematic literature search was conducted on five databases for articles up to December 2023. Arterial calcification, thickness, and stiffness were determined using the calcification score and artery affected, carotid intima–media thickness (CIMT), and pulse wave velocity (PWV), respectively. Sixty-two studies with a total of 27,459 individuals were included in this meta-analysis. Most studies involved chronic kidney disease patients. Study designs were mostly cross-sectional with only one case–control and nine cohorts. FGF-23 was positively correlated with arterial calcification (r = 0.446 [0.254–0.611], p < 0.0001 and aOR = 1.36 [1.09–1.69], p = 0.006), CIMT (r = 0.188 [0.02–0.354], p = 0.03), and PWV (r = 0.235 [0.159–0.310], p < 0.00001). By contrast, Klotho was inversely correlated with arterial calcification (r = − 0.388 [− 0.578 to − 0.159], p = 0.001) and CIMT (r = − 0.38 [− 0.53 to − 0.207], p < 0.00001). In conclusion, FGF-23 and Klotho were associated with arterial calcification, thickness, and stiffness, clarifying their role in arterial remodeling processes.

show abstract

Calcification of abdominal aorta in patients recently starting hemodialysis: A single-center experience from Egypt

Cited by 5 publications

References 14 publications

The Role of Fibroblast Growth Factor 23 in Vascular Calcification in Peritoneal Dialysis Patients

The Role of Fibroblast Growth Factor 23 in Vascular Calcification in Peritoneal Dialysis Patients

Vascular Calcification in Chronic Kidney Disease: An Update and Perspective

Role of klotho and fibroblast growth factor 23 in arterial calcification, thickness, and stiffness: a meta-analysis of observational studies

Contact Info

Product

Resources

About