Calcification in pulmonary nodules: detection with dual-energy digital radiography.

Fraser, Robert G.; Hickey, N; Niklason, Loren T.; Sabbagh, E A; Luna, Licia P.; Alexander, CB; Robinson, C. Andrew; Katzenstein, A L; Barnes, G.T

doi:10.1148/radiology.160.3.3526399

Cited by 57 publications

(22 citation statements)

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“…On the other hand, computer-aided detection (CAD) techniques have been developed for chest radiography, analogous to those used with chest CT, to aid in the detection of lung nodules. Studies have analyzed the diagnostic gain from bone subtraction or suppression and CAD separately [7][8][9][10][11][12][13] Z. Szucs-Farkas received fees from the Riverain Technologies Group for collecting anonymized patient data for a different reader study. That study is not related to the current investigation in any way.…”

Section: Methodsmentioning

confidence: 99%

Comparison of Dual-Energy Subtraction and Electronic Bone Suppression Combined With Computer-Aided Detection on Chest Radiographs: Effect on Human Observers' Performance in Nodule Detection

Szücs-Farkas

Schick

Cullmann

et al. 2013

American Journal of Roentgenology

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very few series have dealt with a combination of these techniques [14,15]. The feasibility of software-only bone suppression on conventional chest radiography in combination with CAD has not been tested to date. Furthermore, of the studies in the literature, most investigators selected image collections in which each image contained only one lesion, a scenario that often does not correspond to the patient collective encountered during daily routine.The aim of the current investigation was to compare the effect of dual-energy subtraction and recently developed bone suppression software alone and in combination with CAD on the diagnostic performance of human observers in lung nodule detection. Materials and MethodsThis retrospective study was performed according to the regulations of the institutional review board and required no informed consent. C onventional chest radiography is still the most frequently performed initial imaging evaluation used worldwide to exclude pulmonary nodules because of its wide accessibility, low cost, and low radiation dose. In past decades, several technical innovations were introduced to improve the sensitivity of this modality. In addition to dual-energy subtraction radiography, other new software techniques have been shown to be capable of decreasing or completely removing the overprojection of bones, mainly of the clavicles and ribs, that significantly hampers the detection of pulmonary nodules on projection radiographs [1][2][3][4][5][6]. On the other hand, computer-aided detection (CAD) techniques have been developed for chest radiography, analogous to those used with chest CT, to aid in the detection of lung nodules. Studies have analyzed the diagnostic gain from bone subtraction or suppression and CAD separately [7][8][9][10][11][12][13] Z. Szucs-Farkas received fees from the Riverain Technologies Group for collecting anonymized patient data for a different reader study. That study is not related to the current investigation in any way. Comparison of Dual-Energy C a r d io p u lm o n a r y I m ag i ng • O r ig i n a l R e s e a rc hOBJECTIVE. The objective of our study was to compare the effect of dual-energy subtraction and bone suppression software alone and in combination with computer-aided detection (CAD) on the performance of human observers in lung nodule detection. MATERIALS AND METHODS.One hundred one patients with from one to five lung nodules measuring 5-29 mm and 42 subjects with no nodules were retrospectively selected and randomized. Three independent radiologists marked suspicious-appearing lesions on the original chest radiographs, dual-energy subtraction images, and bone-suppressed images before and after postprocessing with CAD. Marks of the observers and CAD marks were compared with CT as the reference standard. Data were analyzed using nonparametric tests and the jackknife alternative free-response receiver operating characteristic (JAFROC) method.RESULTS. Using dual-energy subtraction alone (p = 0.0198) or CAD alone (p = 0.0095) improved the detection ra...

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Section: Methodsmentioning

confidence: 99%

Comparison of Dual-Energy Subtraction and Electronic Bone Suppression Combined With Computer-Aided Detection on Chest Radiographs: Effect on Human Observers' Performance in Nodule Detection

Szücs-Farkas

Schick

Cullmann

et al. 2013

American Journal of Roentgenology

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“…DES, in conjunction with a flat-panel detector (FPD), is now commercially available for chest radiography applications [4]. DES has been applied to the detection of calcium in pulmonary nodules [5,6], bone mineral analysis [7], and cardiac imaging [8].…”

Section: Introductionmentioning

confidence: 99%

Dual-Energy Subtraction X-Ray Digital Tomosynthesis: Basic Physical Evaluation

Gomi¹,

Nakajima²

2012

OJMI

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The present study was performed to determine the potential of applying dual-energy subtraction (DES) digital tomosynthesis to basic physical evaluations. Volumetric X-ray DES digital tomosysnthesis was used to obtain an image of a detectability phantom (an artificial lesion). The image quality of DES digital tomosynthesis was compared to that of DES radiography. The purpose of this study was to determine enhanced visibility quantified in terms of the contrastto-noise ratio, figure-of-merit, and root-mean-square error. In the in-focus plane, the image quality is better by DES digital tomosynthesis than by DES radiography. The potential usefulness of DES digital tomosynthesis for evaluating a detectability phantom was demonstrated. Further studies are required to determine the ability of DES digital tomosynthesis to quantify the spatial relationships between the artificial lesion components of these devices, as well as to identify lesions with diagnostic consequences.

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“…A benign pattern of the calcifications has been considered necessary to exclude malignancy [6,[10][11][12][13]. In the evaluation of diffusely disseminated pulmonary nodules, identification of diffusely disseminated pulmonary nodules, identification of calcifications in the nodules has been helpful in limiting the differential diagnosis [14].…”

Section: Introductionmentioning

confidence: 99%

Comparison of Chest Dual-Energy Subtraction Digital Tomosynthesis and Conventional Digital Tomosynthesis for the Detection of Simulated Pulmonary Nodules with Calcifications: Phantom Study

Gomi

Nakajima²,

Fujiwara³

2011

TOMIJ

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Abstract:To compare the effectiveness of chest dual-energy subtraction digital tomosynthesis (DES-DT) with that of conventional digital tomosynthesis for the detection of calcifications superimposed over simulated pulmonary nodules. A DES-DT system with pulsed X-rays and rapid kV switching was used to examine calcifications in simulated pulmonary nodules. Low-voltage, high-voltage, and soft-tissue or bone-subtracted tomograms of the desired layer thicknesses were reconstructed from the image data acquired during a single tomographic scan, bone-subtracted images, and a scan angle of 40°. Our analysis took into account the signal-to-noise ratio (SNR) of the different degrees of calcification in the simulated pulmonary nodules. For DES-DT, the SNR for the simulated pulmonary nodules increased about 63%. Based on the results of receiver operating characteristic performance analysis, the detection ability of our DES-DT was significantly better than that of conventional digital tomosynthesis (P < 0.03). The study results confirmed with a further study to assess influence of reconstruction and filtering for detection of simulated nodules. DES-DT provided greater sensitivity than conventional digital tomosynthesis.

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Calcification in pulmonary nodules: detection with dual-energy digital radiography.

Cited by 57 publications

References 0 publications

Comparison of Dual-Energy Subtraction and Electronic Bone Suppression Combined With Computer-Aided Detection on Chest Radiographs: Effect on Human Observers' Performance in Nodule Detection

Comparison of Dual-Energy Subtraction and Electronic Bone Suppression Combined With Computer-Aided Detection on Chest Radiographs: Effect on Human Observers' Performance in Nodule Detection

Dual-Energy Subtraction X-Ray Digital Tomosynthesis: Basic Physical Evaluation

Comparison of Chest Dual-Energy Subtraction Digital Tomosynthesis and Conventional Digital Tomosynthesis for the Detection of Simulated Pulmonary Nodules with Calcifications: Phantom Study

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