Calcificación pulmonar metastásica: una rara causa de enfermedad pulmonar intersticial

Villalobos, Rodríguez; Becerra, E. Rodríguez; Naranjo, Felipe Borderas; Juan, José Martín

doi:10.1016/s0300-2896(03)75355-1

Cited by 6 publications

(1 citation statement)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The disease process is characterized by interstitial deposition of calcium salts, predominantly in the alveolar epithelial basement membranes ( 7 , 8 ) . Although histological changes of MPC are encountered on autopsy in 60-75% of patients who received hemodialysis ( 1 , 7 , 9 , 10 ) , the condition is much less commonly diagnosed antemortem. This situation is probably the result of the poor sensitivity of standard chest radiographs for the identification of small calcifications, the lack of awareness among clinicians of the imaging manifestations of MPC, and the benign clinical course of the disease ( 11 , 12 ) .…”

Section: Introductionmentioning

confidence: 99%

Metastatic pulmonary calcification: high-resolution computed tomography findings in 23 cases

Belém

Souza

et al. 2017

Radiol Bras

View full text Add to dashboard Cite

ObjectiveThe aim of this study was to evaluate the high-resolution computed tomography (HRCT) findings in patients diagnosed with metastatic pulmonary calcification (MPC).Materials and MethodsWe retrospectively reviewed the HRCT findings from 23 cases of MPC [14 men, 9 women; mean age, 54.3 (range, 26-89) years]. The patients were examined between 2000 and 2014 in nine tertiary hospitals in Brazil, Chile, and Canada. Diagnoses were established by histopathologic study in 18 patients and clinical-radiological correlation in 5 patients. Two chest radiologists analyzed the images and reached decisions by consensus.ResultsThe predominant HRCT findings were centrilobular ground-glass nodules (n = 14; 60.9%), consolidation with high attenuation (n = 10; 43.5%), small dense nodules (n = 9; 39.1%), peripheral reticular opacities associated with small calcified nodules (n = 5; 21.7%), and ground-glass opacities without centrilobular ground-glass nodular opacity (n = 5; 21.7%). Vascular calcification within the chest wall was found in four cases and pleural effusion was observed in five cases. The abnormalities were bilateral in 21 cases.ConclusionMPC manifested with three main patterns on HRCT, most commonly centrilobular ground-glass nodules, often containing calcifications, followed by dense consolidation and small solid nodules, most of which were calcified. We also described another pattern of peripheral reticular opacities associated with small calcified nodules. These findings should suggest the diagnosis of MPC in the setting of hypercalcemia.

show abstract

Section: Introductionmentioning

confidence: 99%

Metastatic pulmonary calcification: high-resolution computed tomography findings in 23 cases

Belém

Souza

et al. 2017

Radiol Bras

View full text Add to dashboard Cite

show abstract

Metastatic pulmonary calcification: State-of-the-art review focused on imaging findings

Belém

Zanetti

Souza

et al. 2014

Respiratory Medicine

154

View full text Add to dashboard Cite

Metastatic pulmonary calcification (MPC) is a subdiagnosed metabolic lung disease that is commonly associated with end-stage renal disease. This interstitial process is characterized by the deposition of calcium salts predominantly in the alveolar epithelial basement membranes. MPC is seen at autopsy in 60-75% of patients with renal failure. It is often asymptomatic, but can potentially progress to respiratory failure. Chest radiographs are frequently normal or demonstrate confluent or patchy airspace opacities. Three patterns visible on high-resolution computed tomography have been described: multiple diffuse calcified nodules, diffuse or patchy areas of ground-glass opacity or consolidation, and confluent high-attenuation parenchymal consolidation. The relative stability of these pulmonary infiltrates, in contrast to infectious processes, and their resistance to treatment, in the clinical context of hypercalcemia, are of diagnostic value. Scintigraphy with bone-seeking radionuclides may demonstrate increased radioactive isotope uptake. The resolution of pulmonary calcification in chronic renal failure may occur after parathyroidectomy, renal transplantation, or dialysis. Thus, the early diagnosis of MPC is beneficial. The aim of this review is to describe the main clinical, pathological, and imaging aspects of MPC.

show abstract

Calcificaciones pulmonares metastásicas en un hiperparatiroidismo terciario

Pons-Escoda

Vilaseca

2014

Radiología

View full text Add to dashboard Cite

Calcificación pulmonar metastásica: una rara causa de enfermedad pulmonar intersticial

Cited by 6 publications

References 4 publications

Metastatic pulmonary calcification: high-resolution computed tomography findings in 23 cases

Metastatic pulmonary calcification: high-resolution computed tomography findings in 23 cases

Metastatic pulmonary calcification: State-of-the-art review focused on imaging findings

Calcificaciones pulmonares metastásicas en un hiperparatiroidismo terciario

Contact Info

Product

Resources

About