Calcific aortic valve stenosis: Immunohistochemical analysis of inflammatory infiltrate

Steiner, I; Krbal, Lukáš; Rozkoš, Tomáš; Harrer, Jan; Laco, Ján

doi:10.1016/j.prp.2012.02.009

Cited by 54 publications

(41 citation statements)

References 15 publications

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“…In this disease, the interstitial cells play an important role, together with different molecular mechanisms. [18][19][20][21] Comparing calcific aortic valve disease and vascular atherosclerosis, many pathogenic common factors can be denoted, while many others remain specific, as mechanical stretching. 22 A careful histological examination permits to clearly distinguish this disease from other conditions, which can involve the aortic valve, such as endocarditis or rheumatism.…”

Section: Resultsmentioning

confidence: 99%

Calcification of the Aortic Valve: the Arrival Point of a Complex Degenerative Process

Manenti¹,

Roncati²,

Casaretta³

et al. 2015

jcvd

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Section: Resultsmentioning

confidence: 99%

Calcification of the Aortic Valve: the Arrival Point of a Complex Degenerative Process

Manenti¹,

Roncati²,

Casaretta³

et al. 2015

jcvd

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“…Recent studies showed that infiltration of lymphocytes and plasma cells into the stenotic aortic valve may not be a rare observation and that IgG4-positive cell infiltration can also be seen in the stenotic aortic valve. [11][12][13] Steiner showed that mild (1-30/hpf) IgG4-positive cell infiltration was observed in 13/178 (7.3%) of calcified aortic valve. 12) Maleszewski, et al demonstrated two cases in whom dense IgG4-positive cell infiltration (> 100/hpf) with IgG4/IgG ratio > 50% was observed in the aortic valve.…”

Section: Discussionmentioning

confidence: 99%

“…[11][12][13] Steiner showed that mild (1-30/hpf) IgG4-positive cell infiltration was observed in 13/178 (7.3%) of calcified aortic valve. 12) Maleszewski, et al demonstrated two cases in whom dense IgG4-positive cell infiltration (> 100/hpf) with IgG4/IgG ratio > 50% was observed in the aortic valve. 13) We also showed that IgG4-positive cell infiltration was observed in 25/139 (18%) of aortic valve samples.…”

Section: Discussionmentioning

confidence: 99%

IgG4-Positive Plasmacytic Infiltration in Aortic Wall and Aortic Valve Surgical Samples and Its Relation to Preoperative Serum IgG4 Levels

et al. 2019

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The prevalence and extent of immunoglobulin G4 (IgG4)-positive cell infiltration were investigated in 282 surgical samples of aortic wall and aortic valve. Tissue infiltration of IgG4-positive cells was observed in 24 (17.3%) of 139 aortic valve samples and 46 (32%) of 143 aortic wall samples, and the condition of IgG4positive cell infiltration > 30/hpf together with IgG4/CD138 ratio > 40% was observed in 2 (1.4%) of aortic valve samples and 14 (9.8%) of aortic wall samples. Among 275 patients, preoperative serum IgG4 level was available in 48 patients (50 samples), and it was > 135 mg/dL in only one patient. Of these 48 patients with serum IgG4 measurement, 29 patients had aortic valve stenosis and 12 had aortic aneurysm. Compared with 23 aortic stenosis patients without tissue infiltration of IgG4-positive cells in the aortic valve, six patients with IgG 4-positive cell infiltration had a more prevalent smoking history (26% versus 83%) and borderline significantly higher serum IgG4 (median, 24.5 mg/dL versus 55.5 mg/dL), although either preoperative peak pressure gradient between left ventriculum and aorta or aortic valve area did not differ significantly between groups. Compared with six aortic aneurysm patients without tissue infiltration of IgG4-positive cells in the aortic wall, six patients with IgG4-positive cell infiltration had borderline significantly higher serum IgG4 (median, 28.9 mg/dL versus 68.2 mg/dL). The current study showed that tissue IgG4-positive infiltration is not a rare occurrence in the aortic stenosis and aortic aneurysm. Clinical significance of tissue IgG4-postive cell infiltration in these patients requires further investigation.

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“…In their study, the mean IgG/IgG4 ratio was 0.27. Thus, aortic valve stenosis does not fulfill the established criteria for IgG4‐related diseases …”

Section: Discussionmentioning

confidence: 99%

Isolated Thoracic Aortitis

et al. 2013

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Calcific aortic valve stenosis: Immunohistochemical analysis of inflammatory infiltrate

Cited by 54 publications

References 15 publications

Calcification of the Aortic Valve: the Arrival Point of a Complex Degenerative Process

Calcification of the Aortic Valve: the Arrival Point of a Complex Degenerative Process

IgG4-Positive Plasmacytic Infiltration in Aortic Wall and Aortic Valve Surgical Samples and Its Relation to Preoperative Serum IgG4 Levels

Isolated Thoracic Aortitis

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