2011
DOI: 10.1161/circulationaha.110.006767
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Calcific Aortic Valve Disease: Not Simply a Degenerative Process

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Cited by 689 publications
(415 citation statements)
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References 96 publications
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“…This correlation is not entirely unexpected, given that CAVD has been associated with hyperlipidemia,10 and stenotic valves are rich in oxidized lipids and apolipoproteins B and E 11, 12. However, in contrast to coronary artery disease (CAD), elevated LDL is considered a relatively weak risk factor for CAVD 10, 13…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…This correlation is not entirely unexpected, given that CAVD has been associated with hyperlipidemia,10 and stenotic valves are rich in oxidized lipids and apolipoproteins B and E 11, 12. However, in contrast to coronary artery disease (CAD), elevated LDL is considered a relatively weak risk factor for CAVD 10, 13…”
Section: Introductionmentioning
confidence: 99%
“…Although less studied than atherosclerosis in FH, the increased incidence of CAVD in FH patients is significant, with over half of homozygous FH (HoFH) males and 21% to 41% of HoFH females exhibiting aortic regurgitation or more‐advanced valvular dysfunction 8, 9. This correlation is not entirely unexpected, given that CAVD has been associated with hyperlipidemia,10 and stenotic valves are rich in oxidized lipids and apolipoproteins B and E 11, 12. However, in contrast to coronary artery disease (CAD), elevated LDL is considered a relatively weak risk factor for CAVD 10, 13…”
Section: Introductionmentioning
confidence: 99%
“…Risk factors for the development of aortic valve sclerosis include older age, male sex, hypertension, smoking, diabetes mellitus, and hypercholesterolemia 1. This listing already suggests a comparable pathogenesis of atherosclerosis and aortic valve sclerosis 2.…”
mentioning
confidence: 92%
“…Until recently, AS was considered as a purely passive degenerative process because of time‐dependent wear and tear of the valve leaflets leading to passive calcium deposition. However, there is now compelling evidence suggesting that AS is an active and multifactorial disease involving numerous pathophysiological processes, such as atherosclerotic‐like processes 1, 2, 3, 4, 5. In this regard, well‐known atherosclerotic risk factors, including age, male sex, smoking, hypertension, hypercholesterolemia, obesity, metabolic syndrome, diabetes mellitus, as well as elevated plasma level of lipoprotein(a) (Lp[a]) have been associated with the development and/or progression of AS 6, 7, 8, 9, 10, 11, 12, 13, 14.…”
Section: Introductionmentioning
confidence: 99%