Calcémie «corrigée»: sous-estimation du statut calcique des patients sans hypoalbuminémie et des patients hypercalcémiques

Parent, Xavier; Spielmann, C; Am, Hanser

doi:10.1684/abc.2009.0348

Cited by 18 publications

(13 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, the levels of total serum calcium fluctuate with serum protein levels as significant proportion of calcium binds to proteins, particularly albumin. To mitigate the errors from dependent factors like albumin on total calcium measurement, adjusted calcium levels are calculated using Parent et al's formula, especially in cases of hypoalbuminemia [7].…”

Section: Discussionmentioning

confidence: 99%

“…According to our laboratory (LabCorp) parameters, true hypocalcemia is defined as the calcium levels less than 8.6 mg/dl after correcting for an abnormal serum albumin, and hypoalbuminemia is defined as albumin levels less than 3.5 mg/dl. Corrected calcium was estimated using Parent et al's formula, i.e., corrected calcium � (0.8 × (normal albumin − patient's albumin)) + serum calcium [7]. e incidence of hypocalcemia events was calculated from the initiation of immune checkpoint inhibitors until their last follow-up.…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Hypocalcemia with Immune Checkpoint Inhibitors: The Disparity among Various Reports

Nalluru

Piranavan

Ning

et al. 2020

International Journal of Endocrinology

View full text Add to dashboard Cite

Immune-related adverse events affecting parathyroid function are rarely reported with immune checkpoint inhibitors (ICPIs). Activating calcium-sensing receptor antibodies causing autoimmune hypoparathyroidism with nivolumab was recently reported. KEYNOTE-189 and CHECKMATE-067 trials reported a 21–29% hypocalcemia event rate, but the etiology of hypocalcemia was not reported. A chart review was performed to study patients receiving ICPI from 2015 to 2018 at multiple sites affiliated with Saint Vincent Hospital. The study population was divided into two groups based on the presence or absence of calcium altering conditions or medications. True hypocalcemia incidence was calculated after correcting calcium for albumin from the initiation of ICPI to their last follow-up. Group 1 (n = 83) includes patients with no calcium altering conditions or medications. Group 2 (n = 98) includes patients on calcium supplements (n = 17), vitamin D (n = 44), bisphosphonates (n = 24), >stage IIIB chronic kidney disease (CKD) (n = 5), and bone metastasis (n = 38). Hypocalcemia events in Group 1 vs. Group 2 were 8.4% and 19.3%, respectively. Our entire study demonstrated 26.8% vs. 1.1% of Grade I vs. II hypocalcemia events. However, after correcting the calcium for albumin, hypocalcemia incidence was 0.56% (n = 1). No further workup was done to investigate the etiology as that patient passed away. Our data suggest that the true hypocalcemia incidence after using albumin-corrected calcium values is very low in patients receiving IPCI, even in the presence of calcium altering factors. The percentage of patients with hypocalcemia is much higher and similar to the KEYNOTE-189 and CHECKMATE-067 trials when serum calcium values without albumin correction are used. Thus, the higher reported incidence of hypocalcemia in these trials is likely due to the reporting of serum calcium without albumin correction.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Hypocalcemia with Immune Checkpoint Inhibitors: The Disparity among Various Reports

Nalluru

Piranavan

Ning

et al. 2020

International Journal of Endocrinology

View full text Add to dashboard Cite

show abstract

“…Fasting blood and urine samples were collected in order to determine Calcium (Ca), Phosphorus (P), Magnesium (Mg), 24-h urine Calcium, 24-h urine Phosphorus, Albumin, Creatinine, C-terminal telopeptide of collagen I (CTX), bone Alkaline Phosphatase (bALP), and Serum Amyloid A (SAA). Calcium corrected for albumin (mmol/l) was calculated as follow: Serum Ca + 0.02 × [40–Albumin (g/l)] (7). Vitamin D [25(OH)D] and parathyroid hormone (PTH) were measured by commercial kits using a chemiluminescent enzyme immunoassay (CLIA).…”

Section: Methodsmentioning

confidence: 99%

Osteoporosis in Systemic Autoinflammatory Diseases: A Case-Control Study

et al. 2019

View full text Add to dashboard Cite

Objective: To assess if patients affected by systemic autoinflammatory diseases (SAIDs) present an increased risk of osteoporosis (OP).Methods: Forty adults patients referred to the Rheumatology Unit of Padova University Hospital affected by Familial Mediterranean Fever (FMF), TNF-Receptor Associated Periodic Syndrome (TRAPS), and Mevalonate Kinase Deficiency (MKD) and 40 healthy subjects were enrolled. Blood and urine samples were collected in order to define phosphocalcic metabolism, including Receptor activator of nuclear factor kappa-B ligand (RANKL) and osteoprotegerin (OPG), and among inflammatory markers serum amyloid A (SAA). Femur and lumbar dual-energy X-ray absorptiometry (DXA) scans were performed and Trabecular Bone Score (TBS) was calculated on DXA lumbar images.Results: We did not observe a statistically significant difference between Bone Mineral Density (BMD) and TBS of patients compared to controls. Also, the values of phosphocalcic metabolites in patients did not statistically differ from those in controls. However, SAA and OPG levels were significantly higher in patients compared to healthy subjects (p = 0.0244 and p = 0.0064, respectively).Conclusion: Patients of our cohort affected by FMF, TRAPS, and MKD do not present an increased risk of OP compared to the healthy controls. TBS and BMD are similar between the two groups underlining a preserved bone quality in patients. High OPG levels could suggest a protective role and a bone re-balancing action in response to an inflammatory background. Finally, it should be taken into account a modulatory role played by a pro-inflammatory cytokine such as SAA on bone homeostasis.

show abstract

“…The concentrations of serum Ca, Alb, IP, Mg, ALP and CK was measured by Colorimetry method using Clinimate CA (SEKISUI Chemical Co. Ltd., Japan), ALB plus (Roche Diagnostics, Mannheim, Germany), Clinimate IP (SEKISUI Chemical Co. Ltd., Japan ), Roche Integra 800 electrode (Roche Diagnostics, Mannheim, Germany), Modular DDP (Roche Diagnostics, Mannheim, Germany) and Hitachi 7600-110 (Hitachi, Japan), respectively. To correct the Ca concentration which is undervalued by abnormal serum protein, Ca(mg/dl) - Alb(g/dl) + 4.0 formula was used [37]. CK was measured by IFCC method using AU 680 (Beckman coulter, USA).…”

Section: Methodsmentioning

confidence: 99%

The effects of a single bout pilates exercise on mRNA expression of bone metabolic cytokines in osteopenia women

Kim

2014

Journal of Exercise Nutrition and Biochemistry

View full text Add to dashboard Cite

[Purpose]The purpose of this study was to examine the effect of a single bout pilates exercise on mRNA expression of bone metabolic cytokines in elderly osteopenia women.[Methods]We selected 11 people of elderly osteopenia women and loaded a single bout pilates exercise about RPE 10-14 level. The blood samples were collected before, immediately after and 60 minute after pilates exercise, then examined calcium metabolic markers in serum and extracted peripheral blood mononuclear cell (PBMC) from whole blood and confirmed mRNA expression of bone metabolic cytokines from PBMC. To clarify the changes during exercise, we designed repeated measure ANOVA as the control group to perform blood sampling without exercise.[Results]As a result, serum P showed significant interaction effect between group and time (p<.001), the pilates exercise group decreased about 9% at immediately after exercise and 13% during recovery after exercise (p<.05), while the control group showed a tendency to increase. Serum CK also showed a significant interaction between group and time (p<.05), the pilates group significantly increased at immediately after exercise and during recovery after exercise (p<.05) but the control group didn’t have changes. TNF-α and IL-6 mRNA expression in PBMC was significantly increased in the pilates group (p<.01, p<.05), although INF-γ mRNA expression didn’t show statistically significant difference, it tended to increase in the pilates group (NS).[Conclusion]These results suggested that a single bout pilates exercise of elderly osteopenia women cause hypophosphatemia with temporary muscle damage, and it leading high turnover bone metabolic state with to activate both of bone formation and bone resorption.

show abstract

Calcémie «corrigée»: sous-estimation du statut calcique des patients sans hypoalbuminémie et des patients hypercalcémiques

Cited by 18 publications

References 0 publications

Hypocalcemia with Immune Checkpoint Inhibitors: The Disparity among Various Reports

Hypocalcemia with Immune Checkpoint Inhibitors: The Disparity among Various Reports

Osteoporosis in Systemic Autoinflammatory Diseases: A Case-Control Study

The effects of a single bout pilates exercise on mRNA expression of bone metabolic cytokines in osteopenia women

Contact Info

Product

Resources

About