Calcemic Responses to Photic and Pharmacologic Manipulation of Serum Melatonin

Hakanson, David O.; Penny, Robert; Bergstrom, William H.

doi:10.1203/00006450-198710000-00010

Cited by 35 publications

(27 citation statements)

References 3 publications

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“…Hakinsons (6) and Hunter (5) hypothesized that phototherapy inhibits pineal secretion of melatonin which blocks the effect of cortisol on bone calcium . so cortisol increases bone uptake of calcium and induces hypocalcaemia.…”

Section: Introductionmentioning

confidence: 99%

Phototherapy Induced Hypocalcemia in Neonatal Hyperbilirubinemia

Singh¹,

Chaudhuri²,

Chaudhary³

2017

IOSR JDMS

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Section: Introductionmentioning

confidence: 99%

Phototherapy Induced Hypocalcemia in Neonatal Hyperbilirubinemia

Singh¹,

Chaudhuri²,

Chaudhary³

2017

IOSR JDMS

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“…5 Romagnoli et al 6 suggested, for the first time, the association of hypocalcemia with phototherapy in preterm neonates. Similarly, Hakanson et al 7 documented this observation in newborn rats. There are few other studies on the hypocalcemic effect of phototherapy.…”

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confidence: 82%

“…4 Phototherapy leads to increased calcium absorption by the bones through irradiating the pineal gland and reducing melatonin level. 7 There is some evidence that the use of a stockinet cap to cover the head prevents phototherapyinduced hypocalcemia. 13 We aimed to study the effect of head covering on the serum calcium levels in neonates with hyperbilirubinemia during phototherapy.…”

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confidence: 99%

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The effect of hat on phototherapy-induced hypocalcemia in jaundiced full-term neonates

Ezzeldin¹,

Mansi²,

Abdel-Hamid³

et al. 2015

RRN

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Background: It has been hypothesized that phototherapy leads to increased calcium absorption by the bones through irradiating the pineal gland and reducing melatonin level. There is some evidence that the use of a stockinet cap to cover the head prevents phototherapy-induced hypocalcemia. Study design: This was a randomized controlled trial, including 124 full-term neonates, weighing .2,500 g, in the first 7 days of life, who developed a bilirubin level ranging from 15 to 20 mg/dL and needed treatment with phototherapy. Our neonates were divided into two groups: Group A without the hat, and Group B with the hat. We designed a dark-colored hat that covered the entire head, including the occipital area, ears, and neck, to prevent passage of light. The hat was used from the time of admission and for the 48 hours of treatment with phototherapy. Ca levels were measured on admission and after 48 hours of phototherapy. The variables were compared using Student's t-test, chi-square test, and the repeated-measures test. Results: There was no difference in the mean Ca levels in the two groups on admission. However, after 48 hours of phototherapy, there was a trend toward an increased Ca level in the group with the hat; 8.74±0.95 mg/dL vs 8.51±0.24 mg/dL in the control group. Moreover, there was a statistically significant decrease in the incidence of neonates with hypocalcemia in Group B (with hat) in only six cases (9.7%), compared to 15 cases (24.2%) in Group A (without hat; P=0.031). Conclusion: Phototherapy-induced hypocalcemia can be prevented by covering the head during phototherapy. This seems to be a safe, effective, and cheap method to prevent hypocalcemia and its complications, with no need for prophylactic administration of calcium.

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“…Pineal gland in normal human, however, is shown to be influenced by the diurnal light dark cycle [6].…”

Section: Introductionmentioning

confidence: 99%