Calcarides A–E, Antibacterial Macrocyclic and Linear Polyesters from a Calcarisporium Strain

Silber, Johanna; Ohlendorf, Birgit; Labes, Antje; Erhard, Arlette; Imhoff, Johannes F.

doi:10.3390/md11093309

Cited by 49 publications

(54 citation statements)

References 18 publications

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“…The bioassays with the clinically relevant bacterial strains Staphylococcus epidermidis (DSM 20044), methicillin-resistant Staphylococcus aureus (MRSA) (DSM 18827), and the causative agent of acne, Propionibacterium acnes (DSM 1897 T ), were performed as described by Silber et al [32]. The phytopathogenic fungus Septoria tritici and the dermatophytic fungus Trichophyton rubrum as well as the cytotoxic effect on the human hepatocellular liver carcinoma cell line HepG2 were tested according to Jansen et al [33].…”

Section: Methodsmentioning

confidence: 99%

Biscogniauxone, a New Isopyrrolonaphthoquinone Compound from the Fungus Biscogniauxia mediterranea Isolated from Deep-Sea Sediments

Wiese

Schmaljohann

et al. 2016

Marine Drugs

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The properties and the production of new metabolites from the fungal strain LF657 isolated from the Herodotes Deep (2800 m depth) in the Mediterranean Sea are reported in this study. The new isolate was identified as Biscogniauxia mediterranea based on ITS1-5.8S-ITS2 and 28S rRNA gene sequences. A new isopyrrolonaphthoquinone with inhibitory activity against glycogen synthase kinase (GSK-3β) was isolated from this fungus. This is the first report of this class of compounds from a fungus isolated from a deep-sea sediment, as well as from a Biscogniauxia species.

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Section: Methodsmentioning

confidence: 99%

Biscogniauxone, a New Isopyrrolonaphthoquinone Compound from the Fungus Biscogniauxia mediterranea Isolated from Deep-Sea Sediments

Wiese

Schmaljohann

et al. 2016

Marine Drugs

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“…The bioassays using the clinically relevant bacterial strains Staphylococcus epidermidis (DSM 20044), the methicillin-resistant Staphylococcus aureus (MRSA) (DSM 18827), and Klebsiella pneumoniae DSM 30104 were performed as described by Silber et al ., 2013 [27]. S. aureus and K. pneumoniae were investigated in the same manner as S. epidermidis.…”

Section: Methodsmentioning

confidence: 99%

Spirocyclic Drimanes from the Marine Fungus Stachybotrys sp. Strain MF347

Oesker

Wiese

et al. 2014

Marine Drugs

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A novel spirocyclic drimane coupled by two drimane fragment building blocks 2 and a new drimane 1 were identified in mycelia and culture broth of Stachybotrys sp. MF347. Their structures were established by spectroscopic means. This is the first example of spirocyclic drimane coupled by a spirodihydrobenzofuranlactam unit and a spirodihydroisobenzofuran unit; and the connecting position being N-C instead of an N and N connecting unit. Strain MF347 produced also the known spirocyclic drimanes stachybocin A (12) and stachybocin B (11) featured by two sesquiterpene-spirobenzofuran structural units connected by a lysine residue; the known spirocyclic drimanes chartarlactam O (5); chartarlactam K (6); F1839A (7); stachybotrylactam (8); stachybotramide (9); and 2α-acetoxystachybotrylactam acetate (10); as well as ilicicolin B (13), a known sesquiterpene. The relative configuration of two known spirobenzofuranlactams (3 and 4) was determined. All compounds were subjected to biological activity tests. The spirocyclic drimane 2, 11, and 12, as well as the sesquiterpene 13, exhibited antibacterial activity against the clinically relevant methicillin-resistant Staphylococcus aureus (MRSA).

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“…Antibacterial bioassays with the test strains Xanthomonas campestris and Staphylococcus epidermidis were performed as described by Silber et al (2013). Bacillus subtilis and Candida albicans were tested as described by Ohlendorf et al (2012).…”

Section: Antibacterial and Antifungal Assaysmentioning

confidence: 99%

Malettinin E, an antibacterial and antifungal tropolone produced by a marine Cladosporium strain

et al. 2014

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The isolation and structure elucidation of malettinins A-C (1-3) along with the new malettinin E (4) are described. The compounds were produced by the fungus Cladosporium sp. strain KF501, which was isolated from the German Wadden Sea. The malettinins are built up of tropolone/dihydropyran ring structures linked to a furan ring. The structure elucidation of the isolated compounds was achieved by means of one-and two-dimensional NMR spectroscopy supported by mass and UV data. The relative configuration of 4 was determined on the basis of single-crystal X-ray diffraction analysis. 1-4 exhibited antibacterial and antifungal activities when profiled against Xanthomonas campestris and Trichophyton rubrum. The influence of the chemical structure of the furan ring and of configurational changes on biological activities was observed.

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Calcarides A–E, Antibacterial Macrocyclic and Linear Polyesters from a Calcarisporium Strain

Cited by 49 publications

References 18 publications

Biscogniauxone, a New Isopyrrolonaphthoquinone Compound from the Fungus Biscogniauxia mediterranea Isolated from Deep-Sea Sediments

Biscogniauxone, a New Isopyrrolonaphthoquinone Compound from the Fungus Biscogniauxia mediterranea Isolated from Deep-Sea Sediments

Spirocyclic Drimanes from the Marine Fungus Stachybotrys sp. Strain MF347

Malettinin E, an antibacterial and antifungal tropolone produced by a marine Cladosporium strain

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