Calcaneal Melanoma; Our Rare Case and Review of the Literature

Karaiskos, Ioannis; Palla, Victoria; Ioannis, Pateras

doi:10.1007/s12262-010-0220-3

Cited by 2 publications

(1 citation statement)

References 8 publications

(13 reference statements)

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“…At present, the etiology of SKCM is not fully understood. It is believed to be multifaceted, with race and genetics, trauma and stimulation, sunlight, immunity and other factors 31 . DNA damage of melanocytes is the basic cause of SKCM.…”

Section: Discussionmentioning

confidence: 99%

Mining novel biomarkers for prognosis of skin cutaneous melanoma with proteomic analysis

Zhang,

Li,

Mao

et al. 2024

Preprint

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Melanoma, a highly malignant tumor arising from melanocytes, poses a significant health threat with increasing incidence. This study leveraged proteomics, analyzing 352 samples from the Cancer Genome Atlas. We identified eight prognosis-related proteins (FOXO3A, CD171, CASPASE7CLEAVEDD198, Melanoma gp100, SRC, 1433ZETA, P21, and CABL) and constructed a prognostic model. The model accurately predicted patient outcomes, distinguishing high- and low-risk groups. Statistical analysis revealed no significant differences in clinical phenotypes between these groups. Principal Component Analysis validated model efficacy, and survival analysis indicated lower overall and progression-free survival in high-risk patients. Independent prognostic analysis and ROC curve analysis affirmed the model's reliability, with a higher predictive capacity than traditional clinical traits. Correlation analysis linked prognosis-related proteins with age, gender, and tumor stage. Our findings contribute valuable insights for diagnostic markers, drug targets, and understanding SKCM pathogenesis, advancing precision medicine. Limitations include the need for subgroup analysis and additional in vitro/in vivo validation.

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Section: Discussionmentioning

confidence: 99%