Calbistrins, novel antifungal agents produced by Penicillium restrictum. I. Production, taxonomy of the producing organism and biological activity.

Jackson, Marianna; Karwowski, James P.; Humphrey, Patrick E.; Kohl, William L.; Barlow, Grant J.; Tanaka, Satoshi

doi:10.7164/antibiotics.46.34

Cited by 61 publications

(24 citation statements)

References 2 publications

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“…As far as we are aware this is the first report of P. oxalicum producing an antifungal substance containing least two active compounds. Fungi of the genus Penicillium are important producers of antibacterial compounds, but only a few are reported to produce antifungal substances (Kumagai et al 1990;Matsukuma et al 1992;Jackson et al 1993;Okada et al 1998;Nose et al 2000;Sasaki et al 2000;Kaiserer et al 2003;He et al 2004;Nicoletti et al 2004). HPLC separation results showed that strain PY-1 produced at least two active compounds which may significantly inhibit mycelial growth of many pathogenic fungi and suppress infection by S. sclerotiorum when aerially applied.…”

Section: Discussionmentioning

confidence: 97%

Antifungal substances produced by Penicillium oxalicum strain PY-1—potential antibiotics against plant pathogenic fungi

Yang

Xiè

Jiāng

et al. 2007

World J Microbiol Biotechnol

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This paper reports the isolation from soil of Penicillium strain PY-1 with strong antagonistic activity against plant pathogenic fungi. On the basis of its morphological characteristics and the sequence of the ITS region, strain PY-1 was identified as P. oxalicum. Strain PY-1 produces antifungal substances that suppress the mycelial growth of Sclerotinia sclerotiorum and many other plant pathogenic fungi tested; the highest antagonistic activity was detected at 72 h when cultured in a 250-ml flask containing 80 ml potato dextrose broth. Compared with carbendazim, the relative activity of the antifungal substances produced by strain PY-1 was approximately 4 lg active ingredient (a.i.) per milliliter. The antifungal substances were extracted with ethyl acetate and further separated by high-performance liquid chromatography (HPLC); at least two active components were discovered. The ability to control plant disease with strain PY-1 was confirmed with S. sclerotiorum, a widespread pathogenic fungus that attacks rapeseed (Brassica napus) and other plants. Spores (10 6 or 10 7 ml -1 ) and filtrate (tenfold diluted or undiluted) of strain PY-1 could significantly suppress infection and/or the extent of infection by S. sclerotiorum of plants at seven-true-leaves stage. The potential of strain PY-1 for identifying new antibiotics to control fungal disease and for biological control of plant disease, for example oilseed rape stem rot, is discussed.

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Section: Discussionmentioning

confidence: 97%

Antifungal substances produced by Penicillium oxalicum strain PY-1—potential antibiotics against plant pathogenic fungi

Yang

Xiè

Jiāng

et al. 2007

World J Microbiol Biotechnol

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“…To our knowledge, the nature and chemical composition of antifungal compounds produced by EU0013 has not been studied. The genus Penicillium produces both antibacterial (Kumagai et al 1990;Matsukuma et al 1992;Jackson et al 1993), and antifungal compounds (Yang et al 2008). In environmentally controlled experiments using sterile potting medium, EU0013 significantly suppressed Fusarium wilt in tomato and cabbage.…”

Section: Discussionmentioning

confidence: 99%

Biocontrol efficiency of Fusarium wilt diseases by a root-colonizing fungusPenicilliumsp.

Alam

Sakamoto

Inubushi

2011

Soil Science and Plant Nutrition

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Soil-inhabiting fungal pathogen Fusarium oxysporum often causes severe yield losses in many crops. We investigated the effect of a plant growth-promoting fungus, Penicillium sp. EU0013 on Fusarium wilt disease. In dual culture experiments, EU0013 inhibited the growth of Fusarium wilt pathogens by producing an inhibition zone. In experiments using sterile potting medium under controlled conditions, EU0013 significantly reduced the severity of Fusarium wilt on tomato (Solanum lycopersicum L.) and cabbage (Brassica oleracea L. var. capitata). In non-sterile soil, benomyl-resistant mutants of EU0013 were selected by exposing the conidial solution of EU0013 to ultraviolet light. The selected mutant EU0013_90S isolate did not show any distinct differences from EU0013 in colony characteristics, growth rate or antifungal activity against Fusarium wilt pathogens in dual culture. The effect of EU0013_90S on tomato wilt was studied under greenhouse conditions using non-sterile soil. Two-weeks old tomato seedlings were dipped in four different concentrations of EU0013_90S conidial suspension (1 Â 10 3

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“…Compound 3 also inhibited aromatase with an IC 50 value of 12.3 lM (Stresser et al, 2000), a useful therapeutic target for the treatment of breast cancer (Brueggemeier et al, 2005). Previously, calbistrins A-D were found to exhibit potent antifungal activity, particularly calbistrin A which displayed MIC values of 0.78 lg/mL (Jackson et al, 1993).…”

Section: Biological Activity Of the Isolated Compounds 1-6mentioning

confidence: 97%

One strain-many compounds (OSMAC) method for production of polyketides, azaphilones, and an isochromanone using the endophytic fungus Dothideomycete sp.

et al. 2014

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Calbistrins, novel antifungal agents produced by Penicillium restrictum. I. Production, taxonomy of the producing organism and biological activity.

Cited by 61 publications

References 2 publications

Antifungal substances produced by Penicillium oxalicum strain PY-1—potential antibiotics against plant pathogenic fungi

Antifungal substances produced by Penicillium oxalicum strain PY-1—potential antibiotics against plant pathogenic fungi

Biocontrol efficiency of Fusarium wilt diseases by a root-colonizing fungusPenicilliumsp.

One strain-many compounds (OSMAC) method for production of polyketides, azaphilones, and an isochromanone using the endophytic fungus Dothideomycete sp.

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