Calabash (Lagenaria siceraria) potency to ameliorate hyperglycemia and oxidative stress in diabetes

Juee, Lana Y.M.; Naqishbandi, Alaadin M.

doi:10.1016/j.jff.2020.103821

Cited by 16 publications

(8 citation statements)

References 32 publications

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“…It results in oxidative stress that obliterate antioxidant defence mechanism of major organs, including testes and kidneys in diabetes 24,36 . Hyperglycemia‐mediated oxidative stress may activate ROS‐sensitive signalling pathways, including pro‐inflammation, culminating into organ damage 36 . In this study, the evaluation of antioxidant defences revealed significant depression in SOD, CAT and GSH‐Px activities in the testes and kidney, whereas the MPO activity and MDA level increased significantly.…”

Section: Discussionmentioning

confidence: 53%

“…Redox imbalance is widely reported in the pathogenesis of diabetes complications. It results in oxidative stress that obliterate antioxidant defence mechanism of major organs, including testes and kidneys in diabetes 24,36 . Hyperglycemia‐mediated oxidative stress may activate ROS‐sensitive signalling pathways, including pro‐inflammation, culminating into organ damage 36 .…”

Section: Discussionmentioning

confidence: 99%

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Tiliacora triandra extract and its major constituent attenuates diabetic kidney and testicular impairment by modulating redox imbalance and pro‐inflammatory responses in rats

Song

Sun²,

et al. 2020

J Sci Food Agric

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BACKGROUND Literature has demonstrated that diabetes is associated with renal complication and testicular dysfunctions. The current study explored the potential of Tiliacora triandra extract and its major component against diabetic kidney and testicular damages in rats. METHODS Diabetes was induced by high fat diet/streptozotocin (HFD/STZ) and treated orally with Tiliacora triandra extract (TTE, 100 and 400 mg kg−1 body weight) and its major component, 5,7‐dihydroxy‐6‐oxoheptadecanoic acid (DHA, 25 mg kg−1 body weight) for 30 consecutive days. Testicular activities of testicular enzymes, serum levels of testosterone, luteinizing hormone (LH) and follicle‐stimulating hormone (FSH), sperm parameters and urinalysis for protein and albumin levels were evaluated. Renal and testicular biomarkers of oxidative stress and pro‐inflammation were analysed along with histology. RESULTS The experimental diabetes induced significant alterations in the levels and activities of indices evaluated compared to non‐diabetic normal rats. The 28‐day treatment of diabetic rats with TTE and DHA markedly improved activities of testicular enzymes, restored levels of testosterone, LH and FSH and sperm parameters compared to untreated diabetic rats. TTE and DHA abrogated proteinuria and reversed urine albumin level. Testicular and renal oxidative stress and pro‐inflammation were attenuated in diabetic rats treated with TTE and DHA. The diabetes‐mediated histopathological damage was alleviated in the kidney and testis. CONCLUSION The protective effect of TTE and DHA against diabetes induced kidney and testicular damages may be related to its antioxidant and anti‐inflammatory activities. © 2020 Society of Chemical Industry

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Section: Discussionmentioning

confidence: 53%

Section: Discussionmentioning

confidence: 99%

Tiliacora triandra extract and its major constituent attenuates diabetic kidney and testicular impairment by modulating redox imbalance and pro‐inflammatory responses in rats

Song

Sun²,

et al. 2020

J Sci Food Agric

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“…Powdered seeds of S. marianum (500 g) were treated with petroleum ether (40–60 °C) at a ratio of 1:10 (w/v) by ultrasonic-assisted extraction (200 kHz, 3h, 40 °C), and the petroleum ether extract was discarded. The remaining plant solid materials were soaked in a mixture of ethanol/water (7:3) at a ratio of 1:10 (w/v) by ultrasonic-assisted extraction (200 kHz, 3h, 40 °C) . The ethanolic extracts were combined and filtered through a Whatman No.1 filter paper in a Buchner funnel, and the filtrate was evaporated in a rotary evaporator at 40 °C, yielding 33.1 g of gummy materials.…”

Section: Materials and Methodsmentioning

confidence: 99%

Preventive and Therapeutic Effects of Silybum marianum Seed Extract Rich in Silydianin and Silychristin in a Rat Model of Metabolic Syndrome

Awla,

Naqishbandi,

Baqi

2023

ACS Pharmacol. Transl. Sci.

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Metabolic syndrome (MetS) has become an increasing global health problem, which leads to cardiovascular diseases and type 2 diabetes. Silybum marianum extracts have been reported to possess several biological activities. In this study, an ethyl acetate extract prepared from S. marianum seeds of the Iraqi Kurdistan region was analyzed to identify its chemical constituents. Subsequently, its potential for the prevention and treatment of MetS was studied in a rat model induced by a high-fat/high-fructose diet (HFD/F). Silydianin and silychristin were the most abundant flavonolignan constituents (39.4%) identified in the S. marianum extract (SMEE). HFD/F-induced rats treated with SMEE exhibited preventive effects including reduced serum triglyceride levels (TG), decreased glucose levels in an oral glucose tolerance test (p < 0.001), attenuated weight gain, and reduced blood pressure compared to the untreated control group. Therapeutic application of SMEE after inducing MetS led to lowering of TG (p < 0.001) and glucose levels, in addition to reducing weight gain and normalizing blood pressure (p < 0.005). Thus, S. marianum extract rich in silydianin and silychristin may be useful for preventing and attenuating MetS, and further research and clinical trials are warranted.

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“…to alleviate the oxidative stress associated with diabetes (29). Antioxidant activity is recognized for phenolics and flavonoids, which have a remarkable capacity to scavenge free radicals created in human bodies.…”

Section: Anti-oxidant Propertiesmentioning

confidence: 99%

Lagenaria siceraria fruit: A review of its phytochemistry, pharmacology, and promising traditional uses

et al. 2022

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Since ancient times, the Cucurbitaceae family is used as a therapeutic option in human medicine. This family has around genera and species. Researchers have studied the various plants of this family including Lagenaria siceraria due to their medicinal potential. Various properties are beneficial for human health, that have been attributed to L. siceraria like antioxidant, hypolipidemic, diuretic, laxative, hepatoprotective, analgesic, antihypertensive, cardioprotective, central nervous system stimulant, anthelmintic, free radical scavenging, immunosuppressive, and adaptogenic. The fruit of this plant is commonly used as a vegetable that has a low-calorie value. The species possess a diverse set of biological compounds like flavonoids, sterols, saponins, and terpenoids. Vitamins, choline, flavonoids, minerals, proteins, terpenoids, and other phytochemicals are also found in the edible parts of this plant. Besides di erent amino acids, many minerals are reported to be present in the seeds of L. siceraria. According to the USDA nutritional database per g of L. siceraria contains Kcal energy, . g carbohydrates, . g protein, . g fat, and . g fiber. L. siceraria performs a wide range of pharmacological and physiological actions. The literature reviewed from various sources including PubMed, Science Direct, Google scholar, etc. shows the remarkable potential to treat various human and animal illnesses due to its' potent bioactive chemicals. The key objective of this thorough analysis is to present a summary of the data about the beneficial and harmful e ects of L. siceraria intake on human health, as well as in veterinary fields.

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Calabash (Lagenaria siceraria) potency to ameliorate hyperglycemia and oxidative stress in diabetes

Cited by 16 publications

References 32 publications

Tiliacora triandra extract and its major constituent attenuates diabetic kidney and testicular impairment by modulating redox imbalance and pro‐inflammatory responses in rats

Tiliacora triandra extract and its major constituent attenuates diabetic kidney and testicular impairment by modulating redox imbalance and pro‐inflammatory responses in rats

Preventive and Therapeutic Effects of Silybum marianum Seed Extract Rich in Silydianin and Silychristin in a Rat Model of Metabolic Syndrome

Lagenaria siceraria fruit: A review of its phytochemistry, pharmacology, and promising traditional uses

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