Caged retinoids as photoinducible activators: implications for cell differentiation and neurite outgrowth

Hoecker, Johannes; Liffert, Raphael; Burch, Patrick A.; Wehlauch, Robin; Gademann, Karl

doi:10.1039/c3ob40106e

Cited by 13 publications

(12 citation statements)

References 25 publications

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“…Previous work has shown that activation of RAR-β stimulates neurite growth (13–15). Because the process of constant cytoskeletal rearrangement in the elongating axon requires a continuous supply of energy in areas distal from the cell body (31), proper mitochondrial distribution is required for axonal regeneration (3), and axonal injury increases mitochondrial movement (4).…”

Section: Discussionmentioning

confidence: 99%

“…It has previously been shown, in refs. [13][14][15], that retinoic acid induces axonal and neurite outgrowth by activating the retinoic acid receptor (RAR)-b, but the role of retinoids in mitochondrial mobilization or recruitment is yet to be described. Furthermore, considering the essential role of mitochondria in neurite elongation, and taking into account the role of hypoxia signaling in peripheral neurite regeneration, it is pertinent to investigate whether retinoic acid promotes neurite elongation in the CNS by acting via this signaling pathway.…”

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confidence: 99%

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The regulation of mitochondrial dynamics in neurite outgrowth by retinoic acid receptor β signaling

2019

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Neuronal regeneration is a highly energy-demanding process that greatly relies on axonal mitochondrial transport to meet the enhanced metabolic requirements. Mature neurons typically fail to regenerate after injury, partly because of mitochondrial motility and energy deficits in injured axons. Retinoic acid receptor (RAR)-β signaling is involved in axonal and neurite regeneration. Here we investigate the effect of RAR-β signaling on mitochondrial trafficking during neurite outgrowth and find that it enhances their proliferation, speed, and movement toward the growing end of the neuron via hypoxia-inducible factor 1α signaling. We also show that RAR-β signaling promotes the binding of the mitochondria to the anchoring protein, glucose-related protein 75, at the growing tip of neurite, thus allowing them to provide energy and metabolic roles required for neurite outgrowth.—Trigo, D., Goncalves, M. B., Corcoran, J. P. T. The regulation of mitochondrial dynamics in neurite outgrowth by retinoic acid receptor β signaling.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

The regulation of mitochondrial dynamics in neurite outgrowth by retinoic acid receptor β signaling

2019

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“…Recently Hoecker et al. deposited acyl homoserine lactone and a nitrodopamine onto biocompatible TiO 2 beads by an operationally simple dip‐and‐rinse procedure, and showed that these beads are capable of inducing quorum sensing (QS) 128a. This hybrid system expands the catechol surface‐modification platform and provides a straightforward method for the preparation of coated surfaces in medical devices able to interrupt the QS signaling pathway in a wide range of different bacterial strains 130.…”

Section: Catecholsmentioning

confidence: 99%

Covalent Surface Modification of Oxide Surfaces

Scheres²,

et al. 2014

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The modification of surfaces by the deposition of a robust overlayer provides an excellent handle with which to tune the properties of a bulk substrate to those of interest. Such control over the surface properties becomes increasingly important with the continuing efforts at down-sizing the active components in optoelectronic devices, and the corresponding increase in the surface area/volume ratio. Relevant properties to tune include the degree to which a surface is wetted by water or oil. Analogously, for biosensing applications there is an increasing interest in so-called "romantic surfaces": surfaces that repel all biological entities, apart from one, to which it binds strongly. Such systems require both long lasting and highly specific tuning of the surface properties. This Review presents one approach to obtain robust surface modifications of the surface of oxides, namely the covalent attachment of monolayers.

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“…However, the application of NGF as a drug is limited because it cannot cross the blood brain barrier (BBB). Thus, finding small molecules that have neurotrophic properties similar to those of NGF (NGF mimics) [6–8] and can cross the BBB is of great importance. Natural products are a great source of compounds for medical uses.…”

Section: Introductionmentioning

confidence: 99%

Neuritogenic Monoglyceride Derived from the Constituent of a Marine Fish for Activating the PI3K/ERK/CREB Signalling Pathways in PC12 Cells

Yang

Luo

Tang

et al. 2013

IJMS

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A neuritogenic monoglyceride, 1-O-(myristoyl) glycerol (MG), was isolated from the head of Ilisha elongate using a PC12 cell bioassay system, and its chemical structure was elucidated using spectroscopic methods. MG significantly induced 42% of the neurite outgrowth of PC12 cells at a concentration of 10 μM. To study the structure-activity relationships of MG, a series of monoglycerides was designed and synthesised. Bioassay results indicated that the alkyl chain length plays a key role in the neuritogenic activity of the monoglycerides. The groups that link the propane-1,2-diol and alkyl chain were also investigated. An ester linkage, rather than an amido one, was found to be optimal for neuritogenic activity. Therefore, 1-O-(stearoyl) glycerol (SG), which induces 57% of the neurite outgrowth of PC12 cells at 10 μM, was determined to be a lead compound for neuritogenic activity. We then investigated the mechanism of action of neurite outgrowth induced by SG on PC12 cells using protein specific inhibitors and Western blot analysis. The mitogen-activated kinase/ERK kinase (MEK) inhibitor U0126 and the phosphatidylinositol-3 kinase (PI3K) inhibitor LY294002 significantly decreased neurite outgrowth. At the same time, SG increased phosphorylation of CREB in protein level. Thus, SG-induced neuritogenic activity depends on the activation of the extracellular-regulated protein kinase (ERK), cAMP responsive element-binding protein (CREB) and PI3K signalling pathways in PC12 cells.

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Caged retinoids as photoinducible activators: implications for cell differentiation and neurite outgrowth

Cited by 13 publications

References 25 publications

The regulation of mitochondrial dynamics in neurite outgrowth by retinoic acid receptor β signaling

The regulation of mitochondrial dynamics in neurite outgrowth by retinoic acid receptor β signaling

Covalent Surface Modification of Oxide Surfaces

Neuritogenic Monoglyceride Derived from the Constituent of a Marine Fish for Activating the PI3K/ERK/CREB Signalling Pathways in PC12 Cells

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