Caged Pt Nanoclusters Exhibiting Corrodibility to Exert Tumor‐Inside Activation for Anticancer Chemotherapeutics

Chien, Chih-Te; Yan, Jiaying; Chiu, Wan-Ching; Wu, Te‐Haw; Liu, Chia-Yeh; Lin, Shu‐Yi

doi:10.1002/adma.201302363

Cited by 43 publications

(47 citation statements)

References 48 publications

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“…For example, platinum(II)‐based drugs, including cisplatin, oxaliplatin, and carboplatin, are extensively utilized as first‐line drugs to treat a series of cancers, including cervical, ovarian, head, and neck, and non‐small‐cell lung cancers . However, their clinical use is greatly limited by the ineffectiveness against drug‐resistant cancers, as well as their adverse effects arising from the poor selectivity to cancerous tissue over normal tissues . Numerous nanomedicines on the basis of platinum(II) complexes have been developed aiming to tumor‐specific delivery by fully taking advantage of active targeting and the enhanced permeability and retention (EPR) effect .…”

Section: Methodsmentioning

confidence: 99%

A Metal–Polyphenol‐Coordinated Nanomedicine for Synergistic Cascade Cancer Chemotherapy and Chemodynamic Therapy

et al. 2019

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The clinical application of chemotherapy is impeded by the unsatisfactory efficacy and severe side effects. Chemodynamic therapy (CDT) has emerged as an efficient strategy for cancer treatment utilizing Fenton chemistry to destroy cancer cells by converting endogenous H2O2 into highly toxic reactive oxygen species. Apart from the chemotherapeutic effect, cisplatin is able to act as an artificial enzyme to produce H2O2 for CDT through cascade reactions, thus remarkably improving the anti‐tumor outcomes. Herein, an organic theranostic nanomedicine (PTCG NPs) is constructed with high loading capability using epigallocatechin‐3‐gallate (EGCG), phenolic platinum(IV) prodrug (Pt‐OH), and polyphenol modified block copolymer (PEG‐b‐PPOH) as the building blocks. The high stability of PTCG NPs during circulation stems from their strong metal–polyphenol coordination interactions, and efficient drug release is realized after cellular internalization. The activated cisplatin elevates the intracellular H2O2 level through cascade reactions. This is further utilized to produce highly toxic reactive oxygen species catalyzed by an iron‐based Fenton reaction. In vitro and in vivo investigations demonstrate that the combination of chemotherapy and chemodynamic therapy achieves excellent anticancer efficacy. Meanwhile, systemic toxicity faced by platinum‐based drugs is avoided through this nanoformulation. This work provides a promising strategy to develop advanced nanomedicine for cascade cancer therapy.

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Section: Methodsmentioning

confidence: 99%

A Metal–Polyphenol‐Coordinated Nanomedicine for Synergistic Cascade Cancer Chemotherapy and Chemodynamic Therapy

et al. 2019

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“…Noble metal nanoparticles (NPs) have been extensively studied for various important applications such as fuel cells [1-], catalysis [4][5][6], surface enhanced Raman scattering (SERS), sensors [7], and biomedical applications [8]. From both experimental investigations on single crystal surfaces and theoretical studies, it has been widely reported that many physical and chemical properties are strongly dependent on the atomic arrangements and thus the crystallographic plane on the surface [9][10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Shape-controlled synthesis of Pt-Ir nanocubes with preferential (100) orientation and their unusual enhanced electrocatalytic activities

Zhong

Liu

et al. 2014

Sci. China Mater.

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Pt-Ir nanocubes with (100)-terminated facets were synthesized for the first time and their unusual high electrocatalytic activity for a model reaction (i.e., ammonia oxidation) was reported. The key parameters in controlling the shape of the PtIr nanocubes were systematically investigated by transmission electron microscopy (TEM). The electrocatalytic activities of the prepared Pt-Ir and pure Pt nanoparticles (NPs) were characterized by cyclic voltammetry (CV). The results showed that the amount of W(CO) 6 and the volume ratio of oleylamine and oleic acid play a significant role in the development of well-defined Pt-Ir nanocubes. The resultant Pt-Ir nanocubes exhibit (100) orientation, which has been confirmed by not only the structural characterization results from high-resolution TEM (HRTEM) and X-ray diffraction (XRD) but also hydrogen desorption profiles obtained from the CV measurements in H 2 SO 4 solution. Lattice contraction of the Pt-Ir nanocubes were suggested by HRTEM and XRD measurements, and the electronic interactions between Pt and Ir in the Pt-Ir nanocubes were demonstrated by X-ray photoelectron spectroscopy. The Pt-Ir nanocubes show higher specific activity than pure Pt nanocubes and much higher specific activity than the polycrystalline Pt-Ir NPs. The much improved specific activity of the Pt-Ir nanocubes could be attributed to the reason that the introduction of Ir in the Pt-Ir nanocubes largely maintains the highly active Pt (100) sites and thus a positive synergistic effect through the addition of Ir to Pt could be achieved due to the possible bifunctional mechanism and the electronic effect.

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“…In fact, Pt nanoparticles are known to kill cancer cells 15−24 by the leached Pt ions under low pH conditions such as the cell endosome. 17,18 Especially when the particle size is reduced to less than 3 nm, >50% of the atoms will be located on the surface of the crystal, 25,26 resulting in increased oxygen adsorption and water oxidation for surface corrosion, 26 thus facilitating Pt ion release for enhanced activity. However, nonspecific targeting of Pt compound has a wide range of toxicity to normal tissues.…”

Section: Introductionmentioning

confidence: 99%

pH-Sensitive Pt Nanocluster Assembly Overcomes Cisplatin Resistance and Heterogeneous Stemness of Hepatocellular Carcinoma

et al. 2016

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Response rates to conventional chemotherapeutics remain unsatisfactory for hepatocellular carcinoma (HCC) due to the high rates of chemoresistance and recurrence. Tumor-initiating cancer stem-like cells (CSLCs) are refractory to chemotherapy, and their enrichment leads to subsequent development of chemoresistance and recurrence. To overcome the chemoresistance and stemness in HCC, we synthesized a Pt nanocluster assembly (Pt-NA) composed of assembled Pt nanoclusters incorporating a pH-sensitive polymer and HCC-targeting peptide. Pt-NA is latent in peripheral blood, readily targets disseminated HCC CSLCs, and disassembles into small Pt nanoclusters in acidic subcellular compartments, eventually inducing damage to DNA. Furthermore, treatment with Pt-NA downregulates a multitude of genes that are vital for the proliferation of HCC. Importantly, CD24+ side population (SP) CSLCs that are resistant to cisplatin are sensitive to Pt-NA, demonstrating the immense potential of Pt-NA for treating chemoresistant HCC.

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Caged Pt Nanoclusters Exhibiting Corrodibility to Exert Tumor‐Inside Activation for Anticancer Chemotherapeutics

Cited by 43 publications

References 48 publications

A Metal–Polyphenol‐Coordinated Nanomedicine for Synergistic Cascade Cancer Chemotherapy and Chemodynamic Therapy

A Metal–Polyphenol‐Coordinated Nanomedicine for Synergistic Cascade Cancer Chemotherapy and Chemodynamic Therapy

Shape-controlled synthesis of Pt-Ir nanocubes with preferential (100) orientation and their unusual enhanced electrocatalytic activities

pH-Sensitive Pt Nanocluster Assembly Overcomes Cisplatin Resistance and Heterogeneous Stemness of Hepatocellular Carcinoma

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