Caga-positive strains of Helicobacter pylori may protect against Barrett's esophagus

Vaezi, Michael F.; Falk, Gary W.; Peek, Richard M.; Vicari, Joseph J.; Goldblum, John R.; Perez-Perez, Guillermo I.; Rice, Thomas W.; Blaser, Martin J.; Richter, Joel E.

doi:10.1111/j.1572-0241.2000.02305.x

Cited by 149 publications

(37 citation statements)

References 12 publications

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“…Five studies were of patients from the Far East, 35 42 45 49 53 seven of patients from North America, 37 38 40 48 50–52 and seven of patients from western Europe. 10 40 42 44 45 47 48 One further study originated from Chile 36.…”

Section: Resultsmentioning

confidence: 99%

Prevalence of Helicobacter pylori in patients with gastro-oesophageal reflux disease: systematic review

Raghunath

2003

BMJ

286

186

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Section: Resultsmentioning

confidence: 99%

Prevalence of Helicobacter pylori in patients with gastro-oesophageal reflux disease: systematic review

Raghunath

2003

BMJ

286

186

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“…The incidence of H. pylori has fallen by 25% between the 1970s and 1990s [35,36]. A significant minority of patients with H. pylori develop atrophic gastritis and are rendered achlorhydric [37,38] and therefore not at risk of acid gastro-esophageal reflux and its complications BE [39,40] 1977-1981 1978-1982 1979-1983 1980-1984 1981-1985 1982-1986 1983-1987 1984-1988 1985-1989 1986-1990 1987-1991 1988-1992 1989-1993 1990-1994 1991-1995 1992-1996 1993-1997 1994-1998 1995-1999 1996-2000 1997-2001 1998-2002 1999-2003 2000-2004 Diagnosis Year…”

Section: Easr Per 100000mentioning

confidence: 99%

The influence of deprivation and ethnicity on the incidence of esophageal cancer in England

Cooper

Day

Brooks

et al. 2009

Cancer Causes Control

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The incidence of esophageal cancer (EC), particularly esophageal adenocarcinoma (EAC), has been rising dramatically. In the USA, esophageal squamous cell carcinoma (ESCC) is associated with deprivation and black ethnicity, while EAC is more common among whites. The influence of social deprivation and ethnicity has not been studied in England. West Midlands Cancer Intelligence Unit data were used to study the incidence of ESCC and EAC, and the influence of age, sex, socioeconomic status (Townsend quintiles by postcode) and ethnicity (to individual patients from Hospital Episode Statistics). From 1977 to 2004, a total of 15,138 EC were identified. Five-year directly age standardized incidence rates per 100,000 (95% CI) for men increased from 8.6 (8.0-9.1) in 1977-1981 to 13.7 (13.1-14.3) in 2000-2004 and for women from 5.0 (4.7-5.4) to 6.3 (5.9-6.6). ESCC incidence did not alter, but EAC incidence rose rapidly in males [2.1 (1.9-2.4) to 8.5 (8.1-9.0)] and in females [0.5 (0.4-0.6) to 1.7 (1.5-1.9)]. ESCC was strongly associated with the most socially deprived quintile. EAC was not associated with differences in socioeconomic status. EAC was significantly more common in white men 7.3 (6.9-7.7) and women 1.5 (1.3-1.6) when compared with black and Asian populations. In England the incidence of EAC has rapidly risen, particularly in men over the last three decades. ESCC was strongly associated with social deprivation. EAC was more common in white populations, but no association with the socioeconomic status was found.

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“…When present, H pylori is the dominant species colonising the human stomach,30 31 and is intimately linked to gastric physiology,32 especially the cagA- positive strains that inject H pylori products into epithelial cells 33. Antibody responses to the CagA protein permit detection of such cag -positive strains,34 which are more interactive with host cells than are cag -negative strains,21 32 and are associated with higher risk for gastric cancer35 and peptic ulcer disease, lower risk of oesophageal reflux and sequelae,8 9 36 37 as well as lower risk of childhood-onset asthma 8–10 12 13 36 37. However, few studies have evaluated the association of H pylori cag positivity with all-cause and cause-specific mortality in healthy individuals.…”

Section: Introductionmentioning

confidence: 99%

Association betweenHelicobacter pyloriand mortality in the NHANES III study

Chen

Segers

Blaser

2013

Gut

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Objective Persistent colonization by Helicobacter pylori, and especially by cagA-positive strains, has been related to several health outcomes with effects in opposite directions. Thus, it is important to evaluate its influence on both total and category-specific mortality. Design We conducted prospective cohort analyses in a nationally representative sample of 9895 participants enrolled in the National Health and Nutrition Examination Survey III (NHANES III) to assess the association of H. pylori status with all-cause and cause-specific mortality. Analyses for the association of H. pylori cagA positivity with mortality were conducted in 7,384 subjects with data on H. pylori cagA status. Results In older individuals (> 40.6 years of age), H. pylori was not associated with all-cause mortality (hazard ratio [HR], 1.00; 95% confidence interval [CI], 0.84–1.18). There was an inverse association of H. pylori status with stroke mortality (HR, 0.67; 95% CI, 0.44–1.08), and the inverse association was stronger for H. pylori cagA positivity, with the HR of 0.45 (95% CI, 0.27–0.75). H. pylori also was strongly positively related to gastric cancer mortality. After we adjusted p-values using the Benjamini–Hochberg false discovery rate (FDR) method to account for multiple comparisons, these associations remained, and H. pylori status was not related to other outcomes.. Conclusion Our findings suggest that H. pylori has a mixed role in human health, but is not a major risk factor for all-cause mortality.

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Caga-positive strains of Helicobacter pylori may protect against Barrett's esophagus

Abstract: Colonization by cagA+ H. pylori strains may be protective against the formation of short- and long-segment Barrett's esophagus and its malignant complications.

Cited by 149 publications

References 12 publications

Prevalence of Helicobacter pylori in patients with gastro-oesophageal reflux disease: systematic review

Prevalence of Helicobacter pylori in patients with gastro-oesophageal reflux disease: systematic review

The influence of deprivation and ethnicity on the incidence of esophageal cancer in England

Association betweenHelicobacter pyloriand mortality in the NHANES III study

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