CagA and VacA<i>Helicobacter Pylori</i>Antibodies in Gastric Cancer

Suriani, Renzo; Colozza, M.; Cardesi, E; Mazzucco, Dario; Marino, M.; Grosso, Silvia; Sanseverinati, Sabina; Venturini, I.; Borghi, A.; Zeneroli, Maria Luisa

doi:10.1155/2008/521724

Cited by 23 publications

(22 citation statements)

References 30 publications

(28 reference statements)

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“…This finding is supported by previous reports including those from Turkey (Sezikli et al, 2006), Italy (Suriani et al, 2008), Mexico (GarzaGonzález et al, 2004) and Chile (Figueroa et al, 2002). Noteworthy is a recent report from highly prevalent countries like China recommend addition of other proteins like OMPs, HP0305, HyuA, and HpaA to CagA and VacA to the risk profile in order to increase the chance of detecting high risk individuals (Epplein et al, 2011).…”

Section: Discussionsupporting

confidence: 81%

“…Accordingly, in a northeast Thai population, absence of reactivity to this protein in the presence of anti 19.5kDa protein was reported as a risk marker for gastric cancer (Chomvarin et al, 2009). Conversely, in another study from Thailand (Suriani et al, 2008) a risk inducing role was reported for H. pylori low molecular weight (35 and 37kDa) antigens in the development of gastrointestinal complications including gastric ulcers and cancer respectively. These low molecular weight antigens were also previously reported by other investigators (Yamaoka et al, 1998) to be closely associated with higher gastric mucosal IL-8 production and peptic ulcers.…”

Section: Discussionmentioning

confidence: 95%

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Seroreactivity to Helicobacter pylori Antigens as a Risk Indicator of Gastric Cancer

Karami¹,

Talebkhan²,

Saberi³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Background: Multiple etiologic factors are suspected to cause gastric cancer, the most important of which is infection with virulent types of Helicobacter pylori. Materials and Methods: We have compared 102 gastric cancer patients with 122 non-ulcer, non-cancer dyspeptic patients. Gastric specimens were evaluated for H. pylori infection by tissue-based detection methods. Patient sera underwent antigen-specific ELISA and western blotting using a Helicoblot 2.1 kit and antibody responses to various H. pylori antigens were assessed. Results: The absolute majority (97-100%) of both groups were H. pylori seropositive. Multivariate regression analysis demonstrated serum antibodies to the low molecular weight 35kDa protein to be protective and reduce the risk of gastric cancer by 60% (OR:0.4; 95%CI:0.1-0.9). Conversely, seroreactivity to the 89kDa (VacA) protein was significantly higher in gastric cancer patients (OR:2.7; 95%CI:1.0-7.1). There was a highly significant association (p<0.001) between seroreactivity to the 116kDa (CagA) and 89kDa (VacA) proteins, and double positive subjects were found at nearly five fold (OR:4.9; 95%CI:1.0-24.4) enhanced risk of gastric cancer as compared to double negative subjects. Conclusions: Seroreactivity to H. pylori low (35kDa) and high (116kDa/89kDa) molecular weight antigens were respectively revealed as protective and risk indicators for gastric cancer.

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Section: Discussionsupporting

confidence: 81%

Section: Discussionmentioning

confidence: 95%

Seroreactivity to Helicobacter pylori Antigens as a Risk Indicator of Gastric Cancer

Karami¹,

Talebkhan²,

Saberi³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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“…There are two plausible explanations for this finding. First, the difference in seropositivity of CagA (75.6%) and of the screening ELISA (66.1%) in GC cases suggests that CagA may have a much stronger antigenicity compared with some other immunogenic proteins, and thus, antibodies against it persist longer after clearance of the infection (23)(24)(25)(26). Second, as shown in Table 6, lower proportions of CagApositive strains were observed among H. pylori-infected controls compared with H. pylori-infected GC cases.…”

Section: Discussionmentioning

confidence: 97%

Helicobacter pylori Infection and Gastric Cancer Risk: Evaluation of 15 H. pylori Proteins Determined by Novel Multiplex Serology

Gao¹,

Michel

Weck³

et al. 2009

Cancer Research

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Infection with Helicobacter pylori is a major cause of gastric cancer (GC). The association likely has been underestimated in the past due to disease-related clearance of the infection. On the other hand, only a minority of the infected individuals develop GC, and better risk stratification is therefore highly desirable. We aimed to assess the association of GC with antibodies to 15 individual H. pylori proteins, determined by novel multiplex serology, to identify potentially relevant risk markers. This analysis was based on 123 GC cases aged 50 to 74 years and 492 age-matched and sex-matched controls from Saarland, Germany. Eight of the antibodies were significantly associated with noncardia GC and seven of them were significantly related to GC at any site. More pronounced associations were observed for noncardia GC; adjusted odds ratios (95% confidence intervals) ranged from 1.60 (1.01-2.54) for HyuA to 5.63 (3.20-9.91) for cytotoxin-associated antigen A (CagA). A dose-response relationship was found between the number of seropositivities and GC (P < 0.001). The seropositivities of CagA and GroEL were found to be independent predictors of GC, which were strongly related to GC risk in a dose-response manner (P < 0.001). In conclusion, GroEL was identified as a new independent risk marker that may contribute to enhanced quantification of H. pylori-related GC risk. [Cancer Res 2009;69(15):6164-70]

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“…Despite the evidence that cagA positivity, cagA and vacA seropositivity, and/or vacA polymorphism contribute to disease severity, numerous studies have not found this association. [163][164][165][166][167][168][169][170][171][172][173][174] For example, in Tunisia, vacA type is significantly different between patients with peptic ulceration and gastritis, while cagA status is not. 175 In China, no association between cagA status and peptic ulceration or chronic gastritis was established, likely due to the high presence of cagA in both patient populations.…”

Section: Vacamentioning

confidence: 99%

Polymorphism in the Helicobacter pylori CagA and VacA toxins and disease

Bridge¹,

Merrell²

2013

Gut Microbes

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CagA and VacAHelicobacter PyloriAntibodies in Gastric Cancer

Abstract: Patients with GC, even when H pylori-negative at the time of the present study, may have been infected by H pylori before the onset of the disease, as confirmed by CagA and VacA seropositivity. These data reinforce the hypothesis that H pylori may be a direct carcinogenic agent of GC.

Cited by 23 publications

References 30 publications

Seroreactivity to Helicobacter pylori Antigens as a Risk Indicator of Gastric Cancer

Seroreactivity to Helicobacter pylori Antigens as a Risk Indicator of Gastric Cancer

Helicobacter pylori Infection and Gastric Cancer Risk: Evaluation of 15 H. pylori Proteins Determined by Novel Multiplex Serology

Polymorphism in the Helicobacter pylori CagA and VacA toxins and disease

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