CAG repeat polymorphism of androgen receptor gene and X-chromosome inactivation in daughters of women with polycystic ovary syndrome (PCOS): relationship with endocrine and metabolic parameters

Echiburú, Bárbara; Pérez-Bravo, Francisco; Maliqueo, Manuel; Guevara, Amanda Ladrón de; Gálvez, Carla; Crisosto, Nicolás; Sir-Petermann, Teresa

doi:10.3109/09513590.2011.650744

Cited by 11 publications

(4 citation statements)

References 26 publications

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“…This study also confirm the elevation in particle number of LDL and a critical reduction in LDL size and assume that androgens may play an important role in pathogenesis of dyslipidemia in women with PCOS [21]. The exact mechanism of dyslipidemia and subsequent hyperandrogenism in PCOS is not clear; hyperandrogenism may lead to changes in lipoprotein levels either by affecting directly at the liver, or by changing body composition by favoring central adiposity [22]. Serum levels of triglycerides, LDL and VLDL is significant high in obese PCOS women comparing to weight matched controls.…”

Section: Discussionsupporting

confidence: 79%

C-Reactive Protein and Adiposity in Women With Polycystic Ovary Syndrome

Fathi¹

2023

Tikrit J. Pure Sci.

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C- reactive protein (CRP) is one of the biomarkers that elevated in obese women with polycystic ovary syndrome (PCOS). PCOS is the most common endocrine disorder, affecting 5-10% of women at reproductive age. It is also called hyperandrogenic anovulation (HA) due to a hormones imbalance in women. Risk factors that predisposing to PCOS including; obesity, decreased physical exercise and family history with PCOS. This syndrome is characterized by overproduction of androgen and ovulatory dysfunction which are accompanied by many clinical and biochemical features including hirsutism, acne, ovary cysts, menstrual irregularities, obesity, dyslipidemia, hyperinsulinemia and glucose intolerance. This study was aimed to: 1. measure serum levels of CRP, total cholesterol, triglyceride, LDL, HDL, VHDL, in addition to calculate Body Mass Index (BMI), in women with PCOS and to compare the results with that of healthy women (Controls). 2. Compare serum CRP, total cholesterol, triglyceride, LDL, HDL and VHDL in normal weight women patients with BMI matched controls. 3. Compare serum CRP, total cholesterol, triglyceride, LDL, HDL and VHDL in obese women patients with BMI matched controls. The present study includes thirty (30) women with PCOS and thirty (30) healthy women served as control. All subjects' age range was between 15 to 40 years, then each group classified into two subgroups depending on BMI. Blood samples were collected and serum was obtained to measure CRP and lipid profile. Polycystic ovarian women group exhibited significantly increased serum levels of CRP (p= 0.001), cholesterol (p= 0.009), triglyceride (p=0.0001) and LDL (p= 0.0001) when compared to healthy control group. BMI also increased in polycystic ovarian women group although it is statistically not significant when compared to controls. Moreover, the serum levels of LDL and HDL in polycystic ovarian women showed non statistical differences when compared to the controls. Our results indicated that CRP is one of biomarkers in obese women with PCOS. Its high level associated with adiposity rather than PCOS itself. PCOS has negative impact on lipid metabolism in normal body weight women and adiposity is played important role in pathogenesis of lipid abnormality in obese women with polycystic ovary syndrome. We concluded from this study that obese women with PCOS having high CRP therefore are more prone to dyslipidemia (atherogenic) and they should routinely screen to prevent further metabolic and cardiac diseases.

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Section: Discussionsupporting

confidence: 79%

C-Reactive Protein and Adiposity in Women With Polycystic Ovary Syndrome

Fathi¹

2023

Tikrit J. Pure Sci.

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“…In addition to the aforementioned factors, familial and/or genetic predisposition may be involved in the increased cardiovascular risk in PCOS patients. The influence of genetic polymorphisms on the metabolic profile of PCOS patients has been studied, and positive associations have been found with lipid profiles ( 16 ), insulin and homocysteine levels ( 17 , 18 ), high body weight and abdominal adiposity ( 19 ).…”

Section: Discussionmentioning

confidence: 99%

Association of glucocorticoid receptor polymorphisms with clinical and metabolic profiles in polycystic ovary syndrome

Maciel¹,

Moreira²,

Bugano³

et al. 2014

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OBJECTIVES:We aimed to investigate whether glucocorticoid receptor gene polymorphisms are associated with clinical and metabolic profiles in patients with polycystic ovary syndrome. Polycystic ovary syndrome is a complex endocrine disease that affects 5-8% of women and may be associated with metabolic syndrome, which is a risk factor for cardiovascular disease. Cortisol action and dysregulation account for metabolic syndrome development in the general population. As glucocorticoid receptor gene (NR3C1) polymorphisms regulate cortisol sensitivity, we hypothesized that variants of this gene may be involved in the adverse metabolic profiles of patients with polycystic ovary syndrome.METHOD:Clinical, metabolic and hormonal profiles were evaluated in 97 patients with polycystic ovary syndrome who were diagnosed according to the Rotterdam criteria. The alleles of the glucocorticoid gene were genotyped. Association analyses were performed using the appropriate statistical tests.RESULTS:Obesity and metabolic syndrome were observed in 42.3% and 26.8% of patients, respectively. Body mass index was positively correlated with blood pressure, triglyceride, LDL-c, total cholesterol, glucose and insulin levels as well as HOMA-IR values and inversely correlated with HDL-c and SHBG levels. The BclI and A3669G variants were found in 24.7% and 13.4% of alleles, respectively. BclI carriers presented a lower frequency of insulin resistance compared with wild-type subjects.CONCLUSION:The BclI variant is associated with a lower frequency of insulin resistance in women with polycystic ovary syndrome. Glucocorticoid gene polymorphism screening during treatment of the syndrome may be useful for identifying subgroups of at-risk patients who would benefit the most from personalized treatment.

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“…However, the CAG repeat numbers differed between lean and obese women with PCOS, wherein the shorter CAG repeats showed up with a greater frequency in the obese-hyperandrogenic sub-type of PCOS women (120). The CAG repeat length and XCI patterns were later also investigated between the daughters of control women and women with PCOS in a Chilean cohort, but the study showed no difference between the two groups (143).…”

Section: Theories On Fetal Reprogramming and Developmental Origins Ofmentioning

confidence: 99%

Pathomechanisms of polycystic ovary syndrome Multidimensional approaches

2018

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Polycystic ovary syndrome is a complex endocrine disorder affecting numerous women of reproductive age across the globe. Characterized mainly by irregular menses, hirsutism, skewed LH: FSH ratios and bulky polycystic ovaries, this multifactorial endocrinopathy results in unfavorable reproductive and metabolic sequelae, including anovulatory infertility, type 2 diabetes, metabolic syndrome and cardiovascular disease in later years. Increasing evidence has shown that the manifestation of polycystic ovary syndrome (PCOS) is attributable to a cumulative impact of altered genetic, epigenetic and protein profiles which bring about a systemic dysfunction. While genetic approaches help ascertain role of causal variants in its etiology, tissue-specific epigenetic patterns help in deciphering the auxiliary role of environmental, nutritional and behavioral factors. Proteomics is advantageous, linking both genotype and phenotype and contributing to biomarker discovery. Investigating molecular mechanism underlying PCOS is imperative in order to gain insight into the pathophysiology of PCOS and formulate novel diagnostic and treatment strategies. In this review we have summarized these three aspects, which have been successfully utilized to delineate the pathomechanisms of PCOS.

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CAG repeat polymorphism of androgen receptor gene and X-chromosome inactivation in daughters of women with polycystic ovary syndrome (PCOS): relationship with endocrine and metabolic parameters

Abstract: AR CAG repeat polymorphism appears to be unrelated with serum androgen levels. However, the short mwCAGn variant may have a possible impact on the lipid profile in PCOSd.

Cited by 11 publications

References 26 publications

C-Reactive Protein and Adiposity in Women With Polycystic Ovary Syndrome

C-Reactive Protein and Adiposity in Women With Polycystic Ovary Syndrome

Association of glucocorticoid receptor polymorphisms with clinical and metabolic profiles in polycystic ovary syndrome

Pathomechanisms of polycystic ovary syndrome Multidimensional approaches

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