Caffeine suppresses the progression of human glioblastoma via cathepsin B and MAPK signaling pathway

Cheng, Yu‐Chen; Ding, Youming; Hueng, Dueng‐Yuan; Chen, Jang-Yi; Chen, Ying

doi:10.1016/j.jnutbio.2016.03.004

Cited by 43 publications

(35 citation statements)

References 34 publications

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“…These results demonstrate that coffee intake reduces T2DM risk via regulation of plasma glucose levels, insulin-glucose homeostasis, islet cell inflammation and pro-inflammatory mediators (43). It has also been reported that caffeine exerts anticancer effects resulting in suppression of carcinogenesis, proliferation, invasion and metastasis (44). Furthermore, several retrospective and prospective studies indicate that long-term caffeinated coffee intake reduces the morbidity and mortality associated with cancer (45,46).…”

Section: Discussionmentioning

confidence: 99%

Caffeine induces sustained apoptosis of human gastric cancer cells by activating the caspase-9/caspase-3 signalling pathway

Liu

Zhou

Tang

2017

Molecular Medicine Reports

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Caffeine is one of the most widely consumed substances found in beverages, and has demonstrated anticancer effects in several types of cancer. The present study aimed to examine the anticancer effects of caffeine on gastric cancer (GC) cells (MGC-803 and SGC-7901) in vitro, and to determine whether the apoptosis-related caspase-9/−3 pathway is associated with these effects. The sustained antiproliferative effects of caffeine on gastric cancer were also investigated. GC cell viability and proliferation were evaluated using cell counting and colony forming assays, following treatment with various concentrations of caffeine. Flow cytometry was performed to assess cell cycle dynamics and apoptosis. Western blot analysis was conducted to detect the activity of the caspase-9/−3 pathway. The results indicated that caffeine treatment significantly suppressed GC cell growth and viability and induced apoptosis by activating the caspase-9/−3 pathway. Furthermore, the anticancer effects of caffeine appeared to be sustained, as the caspase-9/−3 pathway remained active following caffeine withdrawal. In conclusion, caffeine may function as a sustained anticancer agent by activating the caspase-9/−3 pathway, which indicates that it may be useful as a therapeutic candidate in gastric cancer.

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Section: Discussionmentioning

confidence: 99%

Caffeine induces sustained apoptosis of human gastric cancer cells by activating the caspase-9/caspase-3 signalling pathway

Liu

Zhou

Tang

2017

Molecular Medicine Reports

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“…When administered with agomelatine and mianserin (antidepressants), caffeine presented a synergistic effect on the antidepressant activity (Poleszak et al, 2016). Other actions of caffeine include reduced incidence of dyspraxia in children (Doyle et al, 2014), suppressed evolution of glioblastoma (Cheng et al, 2016), and protection against neurodegeneration caused by Parkinson's disease (Xu et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Methylxanthines in 100 Brazilian herbs and infusions: determination and consumption

Meinhart

Caldeirão

2019

Emir J Food Agric

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The contents of caffeine, theophylline and theobromine were studied in 100 plants commercialized in Brazil to investigate new sources of these compounds, and evaluate the consumption of these compounds when these plants are used as infusions (teas). Therefore, two extraction methods were performed, one used an ethanol solution and one used an aqueous infusion process. The extracts were analyzed by ultra-high-performance liquid chromatography. White, green, and black tea (Camellia sinensis) and yerba mate (Ilex paraguariensis) can be considered as potential sources of both caffeine and theobromine. Boldo (Peumus boldus) was a source of theobromine, and small-leaved lime (Tilia cordata), stonebreaker (Phylantus niruri), cow’s foot (Bauhinia forficata) and calendula (Calendula officinalis) presented the highest contents of theophylline. This study highlighted herbs not yet investigated for these compounds. The results obtained may be useful in future studies to evaluate the use of these plants as sources of methylxanthines in foods or drugs.

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“…These data underline the efficacy of caffeine to reduce cancer cell growth compared to other phytochemicals present in coffee extracts. Several studies have described caffeine as anticancer agents by in vitro and in vivo models . For instance, caffeine suppressed the growth of breast cancer cells impairing cell‐cycle progression and enhancing cell death .…”

Section: Discussionmentioning

confidence: 99%

“…Several studies have described caffeine as anticancer agents by in vitro and in vivo models. [35][36][37] For instance, caffeine suppressed the growth of breast cancer cells impairing cell-cycle progression and enhancing cell death. 38 Furthermore, caffeine exhibited antineoplastic activity also against other cancer cells, e.g., melanoma cells.…”

Section: Cancer Epidemiologymentioning

confidence: 99%

Reduction by coffee consumption of prostate cancer risk: Evidence from the Moli‐sani cohort and cellular models

Pounis

Tabolacci

Costanzo

et al. 2017

Intl Journal of Cancer

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Meta-analytic data on the effect of coffee in prostate cancer risk are controversial. Caffeine as a bioactive compound of coffee has not yet been studied in deep in vitro. Our study aimed at evaluating in a population cohort the effect of Italian-style coffee consumption on prostate cancer risk and at investigating in vitro the potential antiproliferative and antimetastatic activity of caffeine on prostate cancer cell lines. 6,989 men of the Moli-sani cohort aged ≥50 years were followed for a mean of 4.24 ± 1.35 years and 100 new prostate cancer cases were identified. The European Prospective Investigation into Cancer and Nutrition-Food Frequency Questionnaire was used for the dietary assessment and the evaluation of Italian-style coffee consumption. Two human prostate cancer cell lines, PC-3 and DU145, were tested with increasing concentrations of caffeine, and their proliferative/metastatic features were evaluated. The newly diagnosed prostate cancer participants presented lower coffee consumption (60.1 ± 51.3 g/day) compared to the disease-free population (74.0 ± 51.7 g/day) (p < 0.05). Multiadjusted analysis showed that the subjects at highest consumption (>3 cups/day) had 53% lower prostate cancer risk as compared to participants at the lowest consumption (0-2 cups/day) (p = 0.02). Both human prostate cancer cell lines treated with caffeine showed a significant reduction in their proliferative and metastatic behaviors (p < 0.05). In conclusion, reduction by Italian-style coffee consumption of prostate cancer risk (>3 cups/day) was observed in epidemiological level. Caffeine appeared to exert both antiproliferative and antimetastatic activity on two prostate cancer cell lines, thus providing a cellular confirmation for the cohort study results.

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Caffeine suppresses the progression of human glioblastoma via cathepsin B and MAPK signaling pathway

Cited by 43 publications

References 34 publications

Caffeine induces sustained apoptosis of human gastric cancer cells by activating the caspase-9/caspase-3 signalling pathway

Caffeine induces sustained apoptosis of human gastric cancer cells by activating the caspase-9/caspase-3 signalling pathway

Methylxanthines in 100 Brazilian herbs and infusions: determination and consumption

Reduction by coffee consumption of prostate cancer risk: Evidence from the Moli‐sani cohort and cellular models

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