Caffeine Stimulates in vivo Platelet Reactivity

Ammaturo, V; Perricone, Corrado; Canazio, A; Ripaldi, Mimmo; Ruggiano, Antonio; Zuccarelli, Bruno; Monti, Mario

doi:10.1111/j.0954-6820.1988.tb19368.x

Cited by 13 publications

(9 citation statements)

References 13 publications

(9 reference statements)

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“…143 Nevertheless, it has also been observed that caffeine might stimulate in vivo platelet reactivity, by increasing the release of β thromboglobulin 1 hour after administration of 100 mg of caffeine. 144 Although Becker et al reported that coffee contains polyphenol haptens that are potentially capable of activating the factor XII-dependent pathway in normal human plasma, 145 Naito et al observed that hot water extracts possess instead anti-thrombin activity. 142 On the other hand, Bak et al failed to observe any significant effect of coffee or caffeine consumption on fibrinogen, clotting factor VII activity, factor VIII antigen, protein C, and protein S. 146 Tsioufis et al reported that coffee inhibits fibrinolysis, probably by increasing the concentration of plasminogen activator inhibitor 1, 147 which is a fast-acting inhibitor of plasminogen activation and it is considered to be an important regulatory element in fibrinolysis.…”

Section: Coffee Consumption and Hemostasismentioning

confidence: 99%

Coffee Intake and Cardiovascular Disease: Virtue Does Not Take Center Stage

Montagnana

Favaloro

Lippi

2012

Semin Thromb Hemost

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Coffee is one of the most popular and heavily consumed beverages worldwide, despite the many different methods of preparation and presentation. The results of several epidemiological studies are suggestive for the existence of a U-shaped relationship between coffee consumption and both cardiovascular events and mortality, whereby a lower risk seems associated with low (i.e., less than one cup per day) or high (i.e., more than or equal to four cups per day) coffee intake, whereas a higher risk is reported for intermediate consumption (i.e., two to four cups per day). Most benefits are evident in individuals with a rapid caffeine metabolizer genotype and a low baseline cardiovascular risk. Benefits have also been differentially associated with consumption of decaffeinated coffee, filtered coffee, coffee consumption during lunchtime or dinner, and when coffee is produced in the Italian style (i.e., by espresso or moka). The leading favorable effects have been attributed to various compounds present in coffee. Thus, chlorogenic acids would be effective in decreasing blood pressure, systemic inflammation, risk of type 2 diabetes, and platelet aggregation, whereas caffeine intake has instead been associated with decreased body weight, as well as with increased flow-mediated dilatation and fibrinolysis.

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Section: Coffee Consumption and Hemostasismentioning

confidence: 99%

Coffee Intake and Cardiovascular Disease: Virtue Does Not Take Center Stage

Montagnana

Favaloro

Lippi

2012

Semin Thromb Hemost

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“…We included 17 experimental studies in this systematic review article, classified into randomized controlled trials, [48][49][50] self-controlled trials, 39,40,[51][52][53][54][55][56] and crossover trials, [57][58][59][60] and two studies are apparently parallel trials. 42,61 Only three studies referred to the sample collec-tion site, which was at the University of Kaiserslautern in Germany, 60 University of California at Davis, 61 and with members of a Department of Nutrition.…”

Section: Resultsmentioning

confidence: 99%

“…42,61 Only three studies referred to the sample collec-tion site, which was at the University of Kaiserslautern in Germany, 60 University of California at Davis, 61 and with members of a Department of Nutrition. 50 The sample size of the studies is variable, with 3 studies covering 8 individuals, 51,55, 59 1 study covering 9, 39 2 studies using 10 individuals, 57,60 another 2 involving 12 people, 42,52 2 articles mentioning 13 participants, 40,54 only 1 using a sample of 14 people, 56 one betting on a sample of 20 individuals, 50 another 2 using 26 49 and 27 people, 53 respectively, one study collecting a sample of 31 people, 61 and 2 studies encompassing a larger sample size with 45 48 and 84 individuals, 58 respectively (Table 1).…”

Section: Resultsmentioning

confidence: 99%

Systematic Review of the Effects of Coffee or Its Components on Platelets and Their Regulators

Gache

Vaz

Almeida-de-Souza

2021

Journal of Caffeine and Adenosine Research

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Background: Coffee includes some potentially bioactive components that can interfere with platelets, which can influence coagulation, despite generating controversy. The aim of this systematic review is to verify whether coffee or its components can influence platelet regulators and/or aggregation. Materials and Methods: The research was conducted on July 29, 2021, in PubMed, Scopus, and Web of Science, using the following mesh-terms: (caffeine)) OR (coffee)) AND (platelets). Eligibility criteria were: studies carried out in humans, referring to the effects of coffee consumption, or one of its components, on platelets or their regulators. We exclude in vitro or animal studies, reviews, editorials, and non-English written studies. From a total of 836 publications, 17 articles were included from which we extracted the relationship between coffee consumption and changes in blood platelets and performed a subjective assessment of bias. Results: Ten articles refer to the non-interference of coffee or its components with platelets, nine affirm results that support the increase in platelet aggregation, and eight articles observe the decrease in platelet aggregation when coffee is consumed. Some articles presented the lack of data regarding the sample collection location, age group, or classification as to the type of study, which is limiting. Conclusions: The heterogeneity of results makes it difficult to correctly interpret the possible interaction of coffee or its components with platelets or their regulators. For better interpretation, further studies on this topic should be carried out considering the individualization of coffee components, different platelet regulators, and the size of the sample used.

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“…Certain fractions of grape skin have been shown to promote aggregation, however, when both stimulatory and inhibitory fractions were tested collectively, grape skin remained inhibitory as a whole [31]. In addition, epinephrine is reported to promote platelet aggregation in whole blood [32,33], however, discrepancies in reports on caffeinated beverages promoting platelet aggregation exist [34,35]. …”

Section: Resultsmentioning

confidence: 99%

Steam-cooking rapidly destroys and reverses onion-induced antiplatelet activity

Hansen

Folts

Goldman

2012

Nutr J

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BackgroundFoods in the diet that can aid in the prevention of diseases are of major interest. Onions are key ingredients in many cuisines around the world and moreover, onion demand has trended higher over the past three decades. An important pharmacological aspect of onion is the ability to inhibit platelet aggregation. Raw onions inhibit platelet aggregation; however, when onions are boiled or heated, antiplatelet activity may be abolished.MethodsOnion quarters were steamed for 0, 1, 3, 6, 10, and 15 min. The in vitro antiplatelet activity of a yellow hybrid storage onion was examined at these times on the blood of 12 human subjects using in vitro whole blood aggregometry.ResultsContrary to findings reported for boiling, antiplatelet activity was destroyed between 3 and 6 min of steaming, and at 10 min of steaming, cooked onions stimulated platelet activity. Extracts from cooked onion had the potential to reverse the inhibitory effect on blood platelets by 25%. Responses were consistent across all donors. Total polyphenolic concentration and soluble solids were not affected by steaming time.ConclusionsThe potential value of cooked onion preparations may result in destruction or reversal of antiplatelet activity, without affecting the polyphenolic concentration.

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Caffeine Stimulates in vivo Platelet Reactivity

Cited by 13 publications

References 13 publications

Coffee Intake and Cardiovascular Disease: Virtue Does Not Take Center Stage

Coffee Intake and Cardiovascular Disease: Virtue Does Not Take Center Stage

Systematic Review of the Effects of Coffee or Its Components on Platelets and Their Regulators

Steam-cooking rapidly destroys and reverses onion-induced antiplatelet activity

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