Caffeine protects against hippocampal alterations in type 2 diabetic rats via modulation of gliosis, inflammation and apoptosis

Othman, Manal; Fadel, Raouf; Tayem, Yasin; Jaradat, Ahmed; Rashid, Aisha; Fatima, Ayesha; Al-Mahameed, Ali E; El-Din, Wael Amin Nasr

doi:10.1007/s00441-022-03735-5

Cited by 4 publications

(2 citation statements)

References 61 publications

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“…Caffeine, functioning as a central nervous system (CNS) stimulant and an adenosine receptor blocker/antagonist, affects the functions of both neurons and glial cells [29][30][31] and regulates the brain's internal environment to a certain extent 29,32 . Recent advancements in imaging techniques allow simultaneous observation of glial and neuronal signals, offering an opportunity to explore caffeine's impact on the activity of these cell types.…”

Section: Aqua2 Identifies Signal Pattern Changes In Zebrafish Astrogl...mentioning

confidence: 99%

Fast, Accurate, and Versatile Data Analysis Platform for the Quantification of Molecular Spatiotemporal Signals

Mi,

Chen,

Duarte

et al. 2024

Preprint

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Optical recording of intricate molecular dynamics is becoming an indispensable technique for biological studies, accelerated by the development of new or improved biosensors and microscopy technology. This creates major computational challenges to extract and quantify biologically meaningful patterns embedded within complex and rich data sources. Here, we introduce Activity Quantification and Analysis (AQuA2), a fast, accurate, and versatile data analysis platform built upon advanced machine learning techniques. AQuA2 decomposes complex live imaging-based datasets into elementary signaling events, allowing accurate and unbiased quantification of molecular activities and identification of consensus functional units. We demonstrate applications of AQuA2 across a range of biosensors (calcium, norepinephrine, ATP, acetylcholine, dopamine), cell types (astrocytes, oligodendrocytes, microglia, neurons), organs (brains and spinal cords), animal models (zebrafish and mouse), and imaging modalities (confocal, two-photon, light sheet). As exemplar findings, we show how AQuA2 identified drug-dependent interactions between neurons and astroglia, and distinct sensorimotor signal propagation patterns in the mouse spinal cord.

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Section: Aqua2 Identifies Signal Pattern Changes In Zebrafish Astrogl...mentioning

confidence: 99%

Fast, Accurate, and Versatile Data Analysis Platform for the Quantification of Molecular Spatiotemporal Signals

Mi,

Chen,

Duarte

et al. 2024

Preprint

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show abstract

“…Interestingly, recent clinical studies linked caffeine consumption with a reduction in risk factors for cardiovascular disorders, type 2 diabetes, hypertension, and the shielding effect in neural cells against neurodegenerative diseases (Lin et al, 2023; O'Keefe et al, 2013; Othman et al, 2023; van Dam & Hu, 2022; Yang et al, 2022). Besides, an epidemiological analysis on the daily consumption of caffeine established a correlation with a reduction in skin cancers, such as nonmelanoma, and wrinkle formation, as well as a protective agent against photoaging (Chiang et al, 2015; Cui et al, 2020; Gajewska et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Current therapeutic targets and multifaceted physiological impacts of caffeine

Song,

Kirtipal,

Lee

et al. 2023

Phytotherapy Research

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Caffeine, which shares consubstantial structural similarity with purine adenosine, has been demonstrated as a nonselective adenosine receptor antagonist for eliciting most of the biological functions at physiologically relevant dosages. Accumulating evidence supports caffeine's beneficial effects against different disorders, such as total cardiovascular diseases and type 2 diabetes. Conversely, paradoxical effects are also linked to caffeine ingestion in humans including hypertension–hypotension and tachycardia–bradycardia. These observations suggest the association of caffeine action with its ingested concentration and/or concurrent interaction with preferential molecular targets to direct explicit events in the human body. Thus, a coherent analysis of the functional targets of caffeine, relevant to normal physiology, and disease pathophysiology, is required to understand the pharmacology of caffeine. This review provides a broad overview of the experimentally validated targets of caffeine, particularly those of therapeutic interest, and the impacts of caffeine on organ‐specific physiology and pathophysiology. Overall, the available empirical and epidemiological evidence supports the dose‐dependent functional activities of caffeine and advocates for further studies to get insights into the caffeine‐induced changes under specific conditions, such as asthma, DNA repair, and cancer, in view of its therapeutic applications.

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Bitter yet beneficial: The dual role of dietary alkaloids in managing diabetes and enhancing cognitive function

Alkanad,

Hani,

et al. 2024

BioFactors

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With the rising prevalence of diabetes and its association with cognitive impairment, interest in the use of dietary alkaloids and other natural products has grown significantly. Understanding how these compounds manage diabetic cognitive dysfunction (DCD) is crucial. This comprehensive review explores the etiology of DCD and the effects of alkaloids in foods and dietary supplements that have been investigated as DCD therapies. Data on how dietary alkaloids like berberine, trigonelline, caffeine, capsaicin, 1‐deoxynojirimycin, nuciferine, neferine, aegeline, tetramethylpyrazine, piperine, and others regulate cognition in diabetic disorders were collected from PubMed, Research Gate, Web of Science, Science Direct, and other relevant databases. Dietary alkaloids could improve memory in behavioral models and modulate the mechanisms underlying the cognitive benefits of these compounds, including their effects on glucose metabolism, gut microbiota, vasculopathy, neuroinflammation, and oxidative stress. Evidence suggests that dietary alkaloids hold promise for improving cognition in diabetic patients and could open exciting avenues for future research in diabetes management.

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Caffeine protects against hippocampal alterations in type 2 diabetic rats via modulation of gliosis, inflammation and apoptosis

Cited by 4 publications

References 61 publications

Fast, Accurate, and Versatile Data Analysis Platform for the Quantification of Molecular Spatiotemporal Signals

Fast, Accurate, and Versatile Data Analysis Platform for the Quantification of Molecular Spatiotemporal Signals

Current therapeutic targets and multifaceted physiological impacts of caffeine

Bitter yet beneficial: The dual role of dietary alkaloids in managing diabetes and enhancing cognitive function

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