Caffeine intoxication: Behavioral and electrocorticographic patterns in Wistar rats

Azevedo, Julianne Elba Cunha; Silva, Alex Luiz Menezes da; Vieira, Luana Rodrigues; Nascimento, Chirlene Pinheiro; Pereira, Rafaela Garcia; Rodrigues, Sofia de França; Hamoy, Akira Otake; Mello, Vanessa Jóia de; Araújo, Daniella Bastos de; Barbas, Luiz André Luz; Crespo-López, María Elena; Lopes, Dielly Catrina Favacho; Hamoy, Moisés

doi:10.1016/j.fct.2022.113452

Cited by 2 publications

(2 citation statements)

References 49 publications

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“…In fact, moderate CAF consumption is believed to increase or improve energy availability, alertness, wakefulness, the ability to concentrate and focus attention, cognitive functioning and motor performance, as well as reduce fatigue and the perception of effort during physical exercise [14]. Moreover, experimental studies have documented that caffeine intoxication at high doses, similarly to pyrethroids, can induce convulsions or cognitive deficits [15,16,17,18]. On the other hand, caffeine administration may result in the enhancement of memory and motor coordination functions in animals [18].…”

Section: Introductionmentioning

confidence: 99%

Assessment of neurobehavioural effects of exposure to Fury 100 EW (zeta-cypermethrin) pyrethroid and caffeine in mice

Łukawski¹,

Zygan-Filipiak²

2023

Med Srod.

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Introduction and Objective.Pyrethroids are widely used pesticides in agriculture. Growing evidence suggests that they may be harmful for human health. Experimental studies show that pyrethroids can induce seizures and impairments of cognitive and motor functions in animals. Caffeine, a widely used psychoactive substance, may influence these disorders. The aim of the current study was to assess whether co-exposure to pyrethroid (zeta-cypermethrin) and caffeine could affect their neurotoxic potential. Materials and method. The study was conducted in adult male Swiss mice. The effects of combined exposure to zetacypermethrin and caffeine on pyrethroid-induced convulsions, as well as learning in the passive avoidance test and motor coordination in the rota-rod test, were assessed in animals. In the current study, Fury 100 EW, an insecticide with zetacypermethrin as an active ingredient, was used. Substances were administered as single intraperitoneal injections. Caffeine was used at doses affecting the neurobehavioural effects of other pesticides, as previously described. Results. Zeta-cypermethrin-induced seizures were not influenced by caffeine (40 mg/kg) administration. Pyrethroid, at its 1/5 CD 50 , did not impair learning or motor coordination in mice. Caffeine did not interact with zeta-cypermethrin in the behavioural tests. Conclusions. Based on the results obtained, it can be concluded that combined exposure to zeta-cypermethrin and caffeine has no effect on their neurotoxic potential in mice.

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Section: Introductionmentioning

confidence: 99%

Assessment of neurobehavioural effects of exposure to Fury 100 EW (zeta-cypermethrin) pyrethroid and caffeine in mice

Łukawski¹,

Zygan-Filipiak²

2023

Med Srod.

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“…Caffeine in a high-dose range, usually exceeding 400 mg/kg in mice [14] or 150 mg/kg in rats [15], produced potent seizure activity. Trimethylxanthine, in much lower doses, was also documented to lower the convulsive threshold in some seizure models.…”

Section: Introductionmentioning

confidence: 99%

Caffeine and Its Interactions with Antiseizure Medications—Is There a Correlation between Preclinical and Clinical Data?

Miziak,

Błaszczyk,

Chrościńska-Krawczyk

et al. 2023

IJMS

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Experimental studies reveal that caffeine (trimethylxanthine) at subconvulsive doses, distinctly reduced the anticonvulsant activity of numerous antiseizure medications (ASMs) in rodents, oxcarbazepine, tiagabine and lamotrigine being the exceptions. Clinical data based on low numbers of patients support the experimental results by showing that caffeine (ingested in high quantities) may sharply increase seizure frequency, considerably reducing the quality of patients’ lives. In contrast, this obviously negative activity of caffeine was not found in clinical studies involving much higher numbers of patients. ASMs vulnerable to caffeine in experimental models of seizures encompass carbamazepine, phenobarbital, phenytoin, valproate, gabapentin, levetiracetam, pregabalin and topiramate. An inhibition of R-calcium channels by lamotrigine and oxcarbazepine may account for their resistance to the trimethylxanthine. This assumption, however, is complicated by the fact that topiramate also seems to be a blocker of R-calcium channels. A question arises why large clinical studies failed to confirm the results of experimental and case-report studies. A possibility exists that the proportion of patients taking ASMs resistant to caffeine may be significant and such patients may be sufficiently protected against the negative activity of caffeine.

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Caffeine intoxication: Behavioral and electrocorticographic patterns in Wistar rats

Cited by 2 publications

References 49 publications

Assessment of neurobehavioural effects of exposure to Fury 100 EW (zeta-cypermethrin) pyrethroid and caffeine in mice

Assessment of neurobehavioural effects of exposure to Fury 100 EW (zeta-cypermethrin) pyrethroid and caffeine in mice

Caffeine and Its Interactions with Antiseizure Medications—Is There a Correlation between Preclinical and Clinical Data?

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